Table 1.

Repeated-measurement analysis

Total cholesterol, mmol/LLDL cholesterol, mmol/LTriglycerides, mmol/LHDL cholesterol, mmol/L
Age, y0.12 (0.02 to 0.22)
P = .0160
0.13 (−0.02 to 0.28)
P = .08
0.19 (−0.06 to 0.44)
P = .14
−0.08 (−0.21 to 0.06)
P = .24
BMI0.19 (0.05 to 0.0.32)
P = .0063
0.63 (0.44 to 0.83)
P ≤ .0001
0.80 (0.47 to 1.13)
P ≤ .0001
−0.59 (−0.77 to −0.41)
P ≤ .0001
Karyotype, 45, X or other3.3% (−3.5% to 10.6%)
P = .34
2.8% (−7.1% to 13.7%)
P = .59
8.8% (−8.5% to 29.4%)
P = .33
4.1% (−6.9% to 16.4%)
P = .47
ERT, Y/N0.4% (−6.0% to 7.2%)
P = .90
−1.6% (−10.5% to 8.2%)
P = .74
2.4% (−13.1% to 20.7%)
P = .77
0.6% (−7.4% to 9.3%)
P = .88
Statin, Y/N−12.0% (−18.2% to −5.3%)
P = .0007
−24.9% (−32.3% to −16.6%)
P ≤ .0001
−4.3% (−20.2% to 14.8%)
P = .63
5.0% (−4.0% to 14.8%)
P = .28
Antidiabetic medication, Y/N−13.3% (−19.5% to −6.6%)
P = .0002
−19.2% (−27.3% to −10.2%)
P ≤ .0001
−0.8% (−16.1% to 21.2%)
P = .92
−5.7% (−13.9% to 3.4%)
P = .21
Total cholesterol, mmol/LLDL cholesterol, mmol/LTriglycerides, mmol/LHDL cholesterol, mmol/L
Age, y0.12 (0.02 to 0.22)
P = .0160
0.13 (−0.02 to 0.28)
P = .08
0.19 (−0.06 to 0.44)
P = .14
−0.08 (−0.21 to 0.06)
P = .24
BMI0.19 (0.05 to 0.0.32)
P = .0063
0.63 (0.44 to 0.83)
P ≤ .0001
0.80 (0.47 to 1.13)
P ≤ .0001
−0.59 (−0.77 to −0.41)
P ≤ .0001
Karyotype, 45, X or other3.3% (−3.5% to 10.6%)
P = .34
2.8% (−7.1% to 13.7%)
P = .59
8.8% (−8.5% to 29.4%)
P = .33
4.1% (−6.9% to 16.4%)
P = .47
ERT, Y/N0.4% (−6.0% to 7.2%)
P = .90
−1.6% (−10.5% to 8.2%)
P = .74
2.4% (−13.1% to 20.7%)
P = .77
0.6% (−7.4% to 9.3%)
P = .88
Statin, Y/N−12.0% (−18.2% to −5.3%)
P = .0007
−24.9% (−32.3% to −16.6%)
P ≤ .0001
−4.3% (−20.2% to 14.8%)
P = .63
5.0% (−4.0% to 14.8%)
P = .28
Antidiabetic medication, Y/N−13.3% (−19.5% to −6.6%)
P = .0002
−19.2% (−27.3% to −10.2%)
P ≤ .0001
−0.8% (−16.1% to 21.2%)
P = .92
−5.7% (−13.9% to 3.4%)
P = .21

Coefficients for repeated-measurement analysis on visit 1 to 4. Estimates are followed by 95% CI in parentheses and P values. P values less than .05 appear in bold. Age and BMI are exponential, for example, ageb while karyotype, ERT, statin, and antidiabetic medication are in percentage changes. For karyotype 45, X is reference to non-45, X. For ERT, statin, and antidiabetic medication, no treatment is reference to treatment, that is, the estimates are the effect of the specific treatment.

Abbreviations: BMI, body mass index; ERT, estrogen replacement therapy; HDL, high-density lipoprotein; LDL, low-density lipoprotein; N, no; Y, yes.

Table 1.

Repeated-measurement analysis

Total cholesterol, mmol/LLDL cholesterol, mmol/LTriglycerides, mmol/LHDL cholesterol, mmol/L
Age, y0.12 (0.02 to 0.22)
P = .0160
0.13 (−0.02 to 0.28)
P = .08
0.19 (−0.06 to 0.44)
P = .14
−0.08 (−0.21 to 0.06)
P = .24
BMI0.19 (0.05 to 0.0.32)
P = .0063
0.63 (0.44 to 0.83)
P ≤ .0001
0.80 (0.47 to 1.13)
P ≤ .0001
−0.59 (−0.77 to −0.41)
P ≤ .0001
Karyotype, 45, X or other3.3% (−3.5% to 10.6%)
P = .34
2.8% (−7.1% to 13.7%)
P = .59
8.8% (−8.5% to 29.4%)
P = .33
4.1% (−6.9% to 16.4%)
P = .47
ERT, Y/N0.4% (−6.0% to 7.2%)
P = .90
−1.6% (−10.5% to 8.2%)
P = .74
2.4% (−13.1% to 20.7%)
P = .77
0.6% (−7.4% to 9.3%)
P = .88
Statin, Y/N−12.0% (−18.2% to −5.3%)
P = .0007
−24.9% (−32.3% to −16.6%)
P ≤ .0001
−4.3% (−20.2% to 14.8%)
P = .63
5.0% (−4.0% to 14.8%)
P = .28
Antidiabetic medication, Y/N−13.3% (−19.5% to −6.6%)
P = .0002
−19.2% (−27.3% to −10.2%)
P ≤ .0001
−0.8% (−16.1% to 21.2%)
P = .92
−5.7% (−13.9% to 3.4%)
P = .21
Total cholesterol, mmol/LLDL cholesterol, mmol/LTriglycerides, mmol/LHDL cholesterol, mmol/L
Age, y0.12 (0.02 to 0.22)
P = .0160
0.13 (−0.02 to 0.28)
P = .08
0.19 (−0.06 to 0.44)
P = .14
−0.08 (−0.21 to 0.06)
P = .24
BMI0.19 (0.05 to 0.0.32)
P = .0063
0.63 (0.44 to 0.83)
P ≤ .0001
0.80 (0.47 to 1.13)
P ≤ .0001
−0.59 (−0.77 to −0.41)
P ≤ .0001
Karyotype, 45, X or other3.3% (−3.5% to 10.6%)
P = .34
2.8% (−7.1% to 13.7%)
P = .59
8.8% (−8.5% to 29.4%)
P = .33
4.1% (−6.9% to 16.4%)
P = .47
ERT, Y/N0.4% (−6.0% to 7.2%)
P = .90
−1.6% (−10.5% to 8.2%)
P = .74
2.4% (−13.1% to 20.7%)
P = .77
0.6% (−7.4% to 9.3%)
P = .88
Statin, Y/N−12.0% (−18.2% to −5.3%)
P = .0007
−24.9% (−32.3% to −16.6%)
P ≤ .0001
−4.3% (−20.2% to 14.8%)
P = .63
5.0% (−4.0% to 14.8%)
P = .28
Antidiabetic medication, Y/N−13.3% (−19.5% to −6.6%)
P = .0002
−19.2% (−27.3% to −10.2%)
P ≤ .0001
−0.8% (−16.1% to 21.2%)
P = .92
−5.7% (−13.9% to 3.4%)
P = .21

Coefficients for repeated-measurement analysis on visit 1 to 4. Estimates are followed by 95% CI in parentheses and P values. P values less than .05 appear in bold. Age and BMI are exponential, for example, ageb while karyotype, ERT, statin, and antidiabetic medication are in percentage changes. For karyotype 45, X is reference to non-45, X. For ERT, statin, and antidiabetic medication, no treatment is reference to treatment, that is, the estimates are the effect of the specific treatment.

Abbreviations: BMI, body mass index; ERT, estrogen replacement therapy; HDL, high-density lipoprotein; LDL, low-density lipoprotein; N, no; Y, yes.

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