Calculation table for prediction of IGF-Iavg SDS and IGF-Iavg concentration (ng/mL) values by time after dose
| . | Calculating IGF-Iavg SDS . | Calculating IGF-Iavg concentration (ng/mL) . | ||
|---|---|---|---|---|
| Interval (time after dose) . | Adjustment to measured IGF-I SDS to approximate IGF-Iavg SDSa . | 90% prediction interval of IGF-I SDS adjustment value . | Adjustment to measured IGF-I (ng/mL) to approximate IGF-Iavg (ng/mL)b . | Coefficient of variation (%) of IGF-I (ng/mL) adjustment value . |
| 25-48 hours | IGF-I SDS −0.8 | ±0.5 | IGF-I (ng/mL) × 0.8 | 9.0 |
| 49-72 hours | IGF-I SDS −1 | ±0.6 | IGF-I (ng/mL) × 0.7 | 8.3 |
| 73-96 hours | IGF-I SDS −0.5 | ±0.4 | IGF-I (ng/mL) × 0.9 | 7.4 |
| 97-120 hours | No adjustmentc | N/A | No adjustmentc | N/A |
| 121-144 hours | IGF-I SDS +0.7 | ±0.4 | IGF-I (ng/mL) × 1.3 | 10 |
| 145-168 hours | IGF-I SDS +1.1 | ±0.6 | IGF-I (ng/mL) × 1.6 | 15 |
| . | Calculating IGF-Iavg SDS . | Calculating IGF-Iavg concentration (ng/mL) . | ||
|---|---|---|---|---|
| Interval (time after dose) . | Adjustment to measured IGF-I SDS to approximate IGF-Iavg SDSa . | 90% prediction interval of IGF-I SDS adjustment value . | Adjustment to measured IGF-I (ng/mL) to approximate IGF-Iavg (ng/mL)b . | Coefficient of variation (%) of IGF-I (ng/mL) adjustment value . |
| 25-48 hours | IGF-I SDS −0.8 | ±0.5 | IGF-I (ng/mL) × 0.8 | 9.0 |
| 49-72 hours | IGF-I SDS −1 | ±0.6 | IGF-I (ng/mL) × 0.7 | 8.3 |
| 73-96 hours | IGF-I SDS −0.5 | ±0.4 | IGF-I (ng/mL) × 0.9 | 7.4 |
| 97-120 hours | No adjustmentc | N/A | No adjustmentc | N/A |
| 121-144 hours | IGF-I SDS +0.7 | ±0.4 | IGF-I (ng/mL) × 1.3 | 10 |
| 145-168 hours | IGF-I SDS +1.1 | ±0.6 | IGF-I (ng/mL) × 1.6 | 15 |
Abbreviations: avg, average; CV, coefficient of variation; GHD, growth hormone deficiency; hrs, hours after dose; IGF-I, insulin-like growth factor I; PI, prediction interval; SDS, standard deviation score.
Adjustment of IGF-I SDS values should be performed by either adding or subtracting the value provided in the table according to the time point when the sample was obtained.
Adjustment of IGF-I (ng/mL) concentration values should be performed through multiplying by the factor provided in the table according to the time point when the sample was obtained.
Adjustment for values obtained 97-120 hours after dose is considered not to be required as the predicted adjustments of IGF-I SDS +0.1 (PI 90% +/0.3 SDS) and IGF-I (ng/mL) × 1.1 (6.9 CV%) are not clinically relevant.
Calculation table for prediction of IGF-Iavg SDS and IGF-Iavg concentration (ng/mL) values by time after dose
| . | Calculating IGF-Iavg SDS . | Calculating IGF-Iavg concentration (ng/mL) . | ||
|---|---|---|---|---|
| Interval (time after dose) . | Adjustment to measured IGF-I SDS to approximate IGF-Iavg SDSa . | 90% prediction interval of IGF-I SDS adjustment value . | Adjustment to measured IGF-I (ng/mL) to approximate IGF-Iavg (ng/mL)b . | Coefficient of variation (%) of IGF-I (ng/mL) adjustment value . |
| 25-48 hours | IGF-I SDS −0.8 | ±0.5 | IGF-I (ng/mL) × 0.8 | 9.0 |
| 49-72 hours | IGF-I SDS −1 | ±0.6 | IGF-I (ng/mL) × 0.7 | 8.3 |
| 73-96 hours | IGF-I SDS −0.5 | ±0.4 | IGF-I (ng/mL) × 0.9 | 7.4 |
| 97-120 hours | No adjustmentc | N/A | No adjustmentc | N/A |
| 121-144 hours | IGF-I SDS +0.7 | ±0.4 | IGF-I (ng/mL) × 1.3 | 10 |
| 145-168 hours | IGF-I SDS +1.1 | ±0.6 | IGF-I (ng/mL) × 1.6 | 15 |
| . | Calculating IGF-Iavg SDS . | Calculating IGF-Iavg concentration (ng/mL) . | ||
|---|---|---|---|---|
| Interval (time after dose) . | Adjustment to measured IGF-I SDS to approximate IGF-Iavg SDSa . | 90% prediction interval of IGF-I SDS adjustment value . | Adjustment to measured IGF-I (ng/mL) to approximate IGF-Iavg (ng/mL)b . | Coefficient of variation (%) of IGF-I (ng/mL) adjustment value . |
| 25-48 hours | IGF-I SDS −0.8 | ±0.5 | IGF-I (ng/mL) × 0.8 | 9.0 |
| 49-72 hours | IGF-I SDS −1 | ±0.6 | IGF-I (ng/mL) × 0.7 | 8.3 |
| 73-96 hours | IGF-I SDS −0.5 | ±0.4 | IGF-I (ng/mL) × 0.9 | 7.4 |
| 97-120 hours | No adjustmentc | N/A | No adjustmentc | N/A |
| 121-144 hours | IGF-I SDS +0.7 | ±0.4 | IGF-I (ng/mL) × 1.3 | 10 |
| 145-168 hours | IGF-I SDS +1.1 | ±0.6 | IGF-I (ng/mL) × 1.6 | 15 |
Abbreviations: avg, average; CV, coefficient of variation; GHD, growth hormone deficiency; hrs, hours after dose; IGF-I, insulin-like growth factor I; PI, prediction interval; SDS, standard deviation score.
Adjustment of IGF-I SDS values should be performed by either adding or subtracting the value provided in the table according to the time point when the sample was obtained.
Adjustment of IGF-I (ng/mL) concentration values should be performed through multiplying by the factor provided in the table according to the time point when the sample was obtained.
Adjustment for values obtained 97-120 hours after dose is considered not to be required as the predicted adjustments of IGF-I SDS +0.1 (PI 90% +/0.3 SDS) and IGF-I (ng/mL) × 1.1 (6.9 CV%) are not clinically relevant.
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