Association between urinary selenium excretion and all-cause mortality in KTR.
. | Tertiles of urinary selenium excretiona . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
. | Tertile 1 . | Tertile 2 . | Tertile 3 . | Urinary selenium excretion, log2 . | ||||||
Models | HR | 95% CI | P | HR | 95% CI | P | Ref | HR | 95% CI | P |
Crude | 2.36 | 1.70‒3.28 | <.001 | 1.34 | 0.94‒1.91 | .11 | Ref | 0.55 | 0.44‒0.70 | <.001 |
Model 1 | 2.49 | 1.76‒3.54 | <.001 | 1.35 | 0.94‒1.93 | .11 | Ref | 0.55 | 0.42‒0.71 | <.001 |
Model 2 | 2.12 | 1.45‒3.11 | <.001 | 1.18 | 0.79‒1.75 | .41 | Ref | 0.63 | 0.48‒0.84 | .001 |
Model 3 | 2.18 | 1.52‒3.12 | <.001 | 1.23 | 0.86‒1.77 | .26 | Ref | 0.62 | 0.48‒0.81 | <.001 |
Model 4 | 2.46 | 1.73‒3.49 | <.001 | 1.36 | 0.94‒1.95 | .10 | Ref | 0.57 | 0.44‒0.73 | <.001 |
Model 5 | 2.47 | 1.74‒3.50 | <.001 | 1.33 | 0.93‒1.91 | .12 | Ref | 0.55 | 0.43‒0.71 | <.001 |
. | Tertiles of urinary selenium excretiona . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
. | Tertile 1 . | Tertile 2 . | Tertile 3 . | Urinary selenium excretion, log2 . | ||||||
Models | HR | 95% CI | P | HR | 95% CI | P | Ref | HR | 95% CI | P |
Crude | 2.36 | 1.70‒3.28 | <.001 | 1.34 | 0.94‒1.91 | .11 | Ref | 0.55 | 0.44‒0.70 | <.001 |
Model 1 | 2.49 | 1.76‒3.54 | <.001 | 1.35 | 0.94‒1.93 | .11 | Ref | 0.55 | 0.42‒0.71 | <.001 |
Model 2 | 2.12 | 1.45‒3.11 | <.001 | 1.18 | 0.79‒1.75 | .41 | Ref | 0.63 | 0.48‒0.84 | .001 |
Model 3 | 2.18 | 1.52‒3.12 | <.001 | 1.23 | 0.86‒1.77 | .26 | Ref | 0.62 | 0.48‒0.81 | <.001 |
Model 4 | 2.46 | 1.73‒3.49 | <.001 | 1.36 | 0.94‒1.95 | .10 | Ref | 0.57 | 0.44‒0.73 | <.001 |
Model 5 | 2.47 | 1.74‒3.50 | <.001 | 1.33 | 0.93‒1.91 | .12 | Ref | 0.55 | 0.43‒0.71 | <.001 |
Tertile 1: <16.4 μg/24-h; tertile 2: 16.4‒21.6 μg/24-h; tertile 3: >21.6 μg/24-h. In total, 229 (33%) KTR died (tertile 1: 107, tertile 2: 68, tertile 3: 54). Model 1: adjustment for age, sex and body surface area. Model 2: Model 1 + plasma albumin concentration, and protein, bread, fruit, vegetable and bread intake. Model 3: Model 1 + proteinuria, eGFR and urinary volume. Model 4: Model 1 + pre-emptive transplantation, living donor and time since transplantation. Model 5: Model 1 + calcineurin inhibitor usage, proliferation inhibitor usage and acute rejection treatment.
Association between urinary selenium excretion and all-cause mortality in KTR.
. | Tertiles of urinary selenium excretiona . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
. | Tertile 1 . | Tertile 2 . | Tertile 3 . | Urinary selenium excretion, log2 . | ||||||
Models | HR | 95% CI | P | HR | 95% CI | P | Ref | HR | 95% CI | P |
Crude | 2.36 | 1.70‒3.28 | <.001 | 1.34 | 0.94‒1.91 | .11 | Ref | 0.55 | 0.44‒0.70 | <.001 |
Model 1 | 2.49 | 1.76‒3.54 | <.001 | 1.35 | 0.94‒1.93 | .11 | Ref | 0.55 | 0.42‒0.71 | <.001 |
Model 2 | 2.12 | 1.45‒3.11 | <.001 | 1.18 | 0.79‒1.75 | .41 | Ref | 0.63 | 0.48‒0.84 | .001 |
Model 3 | 2.18 | 1.52‒3.12 | <.001 | 1.23 | 0.86‒1.77 | .26 | Ref | 0.62 | 0.48‒0.81 | <.001 |
Model 4 | 2.46 | 1.73‒3.49 | <.001 | 1.36 | 0.94‒1.95 | .10 | Ref | 0.57 | 0.44‒0.73 | <.001 |
Model 5 | 2.47 | 1.74‒3.50 | <.001 | 1.33 | 0.93‒1.91 | .12 | Ref | 0.55 | 0.43‒0.71 | <.001 |
. | Tertiles of urinary selenium excretiona . | . | . | . | ||||||
---|---|---|---|---|---|---|---|---|---|---|
. | Tertile 1 . | Tertile 2 . | Tertile 3 . | Urinary selenium excretion, log2 . | ||||||
Models | HR | 95% CI | P | HR | 95% CI | P | Ref | HR | 95% CI | P |
Crude | 2.36 | 1.70‒3.28 | <.001 | 1.34 | 0.94‒1.91 | .11 | Ref | 0.55 | 0.44‒0.70 | <.001 |
Model 1 | 2.49 | 1.76‒3.54 | <.001 | 1.35 | 0.94‒1.93 | .11 | Ref | 0.55 | 0.42‒0.71 | <.001 |
Model 2 | 2.12 | 1.45‒3.11 | <.001 | 1.18 | 0.79‒1.75 | .41 | Ref | 0.63 | 0.48‒0.84 | .001 |
Model 3 | 2.18 | 1.52‒3.12 | <.001 | 1.23 | 0.86‒1.77 | .26 | Ref | 0.62 | 0.48‒0.81 | <.001 |
Model 4 | 2.46 | 1.73‒3.49 | <.001 | 1.36 | 0.94‒1.95 | .10 | Ref | 0.57 | 0.44‒0.73 | <.001 |
Model 5 | 2.47 | 1.74‒3.50 | <.001 | 1.33 | 0.93‒1.91 | .12 | Ref | 0.55 | 0.43‒0.71 | <.001 |
Tertile 1: <16.4 μg/24-h; tertile 2: 16.4‒21.6 μg/24-h; tertile 3: >21.6 μg/24-h. In total, 229 (33%) KTR died (tertile 1: 107, tertile 2: 68, tertile 3: 54). Model 1: adjustment for age, sex and body surface area. Model 2: Model 1 + plasma albumin concentration, and protein, bread, fruit, vegetable and bread intake. Model 3: Model 1 + proteinuria, eGFR and urinary volume. Model 4: Model 1 + pre-emptive transplantation, living donor and time since transplantation. Model 5: Model 1 + calcineurin inhibitor usage, proliferation inhibitor usage and acute rejection treatment.
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