Table 2
Open in new tab

Associations of hypertension with CMR metrics in fully adjusted linear regression models stratified by sex

Whole sampleWomenMenHypertension × sex interaction
LAVi0.159* [0.130, 0.188]0.142* [0.105, 0.180]0.176* [0.132, 0.220]0.050 [−0.002, 0.103]
3.81 × 10−271.60 × 10−135.26 × 10−150.0617
LAEF−0.117* [−0.146, −0.089]−0.124* [−0.162, −0.086]−0.108* [−0.151, −0.065]−0.017 [−0.069, 0.035]
1.08 × 10−151.52 × 10−109.77 × 10−70.5218
LVEDVi0.101* [0.077, 0.125]0.088* [0.060, 0.116]0.119* [0.080, 0.157]−0.020 [−0.063, 0.024]
8.31 × 10−171.36 × 10−91.29 × 10−90.3741
LVSVi0.113* [0.088, 0.138]0.109* [0.077, 0.141]0.121* [0.082, 0.160]−0.037 [−0.082, 0.009]
1.42 × 10−181.61 × 10−111.42 × 10−90.1149
LVMi0.258* [0.238, 0.279]0.238* [0.213, 0.262]0.283* [0.250, 0.316]0.005 [−0.032, 0.042]
2.20 × 10−1332.70 × 10−802.74 × 10−620.7873
LVM/LVEDV0.200* [0.177, 0.223]0.206* [0.177, 0.235]0.193* [0.157, 0.228]−0.003 [−0.045, 0.039]
2.21 × 10−645.16 × 10−447.70 × 10−260.8788
Maximal WT0.240* [0.219, 0.261]0.243* [0.217, 0.269]0.236* [0.203, 0.269]−0.001 [−0.039, 0.038]
8.51 × 10−1102.40 × 10−731.37 × 10−440.9759
LVEF0.038* [0.013, 0.063]0.048* [0.014, 0.082]0.029 [−0.008, 0.067]−0.030 [−0.076, 0.017]
0.00320.00570.12740.2097
LV GFI−0.057* [−0.081, −0.033]−0.058* [−0.092, −0.024]−0.056* [−0.090, −0.023]0.003 [−0.040, 0.047]
2.66 × 10−67.61 × 10−40.00110.8881
GLS0.049* [0.021, 0.077]0.042 [0.002, 0.082]0.055* [0.015, 0.095]0.025 [−0.027, 0.076]
6.91 × 10−40.03940.00690.3475
Native T1−0.060* [−0.081, −0.038]−0.117* [−0.148, −0.087]−0.008 [−0.038, 0.023]0.210* [0.170, 0.249]
5.91 × 10−84.07 × 10−140.62431.17 × 10−25
AoD−0.174* [−0.194, −0.153]−0.199* [−0.228, −0.169]−0.146* [−0.174, −0.119]0.076* [0.039, 0.113]
2.38 × 10−624.54 × 10−392.39 × 10−256.46 × 10−5
Whole sampleWomenMenHypertension × sex interaction
LAVi0.159* [0.130, 0.188]0.142* [0.105, 0.180]0.176* [0.132, 0.220]0.050 [−0.002, 0.103]
3.81 × 10−271.60 × 10−135.26 × 10−150.0617
LAEF−0.117* [−0.146, −0.089]−0.124* [−0.162, −0.086]−0.108* [−0.151, −0.065]−0.017 [−0.069, 0.035]
1.08 × 10−151.52 × 10−109.77 × 10−70.5218
LVEDVi0.101* [0.077, 0.125]0.088* [0.060, 0.116]0.119* [0.080, 0.157]−0.020 [−0.063, 0.024]
8.31 × 10−171.36 × 10−91.29 × 10−90.3741
LVSVi0.113* [0.088, 0.138]0.109* [0.077, 0.141]0.121* [0.082, 0.160]−0.037 [−0.082, 0.009]
1.42 × 10−181.61 × 10−111.42 × 10−90.1149
LVMi0.258* [0.238, 0.279]0.238* [0.213, 0.262]0.283* [0.250, 0.316]0.005 [−0.032, 0.042]
2.20 × 10−1332.70 × 10−802.74 × 10−620.7873
LVM/LVEDV0.200* [0.177, 0.223]0.206* [0.177, 0.235]0.193* [0.157, 0.228]−0.003 [−0.045, 0.039]
2.21 × 10−645.16 × 10−447.70 × 10−260.8788
Maximal WT0.240* [0.219, 0.261]0.243* [0.217, 0.269]0.236* [0.203, 0.269]−0.001 [−0.039, 0.038]
8.51 × 10−1102.40 × 10−731.37 × 10−440.9759
LVEF0.038* [0.013, 0.063]0.048* [0.014, 0.082]0.029 [−0.008, 0.067]−0.030 [−0.076, 0.017]
0.00320.00570.12740.2097
LV GFI−0.057* [−0.081, −0.033]−0.058* [−0.092, −0.024]−0.056* [−0.090, −0.023]0.003 [−0.040, 0.047]
2.66 × 10−67.61 × 10−40.00110.8881
GLS0.049* [0.021, 0.077]0.042 [0.002, 0.082]0.055* [0.015, 0.095]0.025 [−0.027, 0.076]
6.91 × 10−40.03940.00690.3475
Native T1−0.060* [−0.081, −0.038]−0.117* [−0.148, −0.087]−0.008 [−0.038, 0.023]0.210* [0.170, 0.249]
5.91 × 10−84.07 × 10−140.62431.17 × 10−25
AoD−0.174* [−0.194, −0.153]−0.199* [−0.228, −0.169]−0.146* [−0.174, −0.119]0.076* [0.039, 0.113]
2.38 × 10−624.54 × 10−392.39 × 10−256.46 × 10−5

Results are standardised Beta coefficients, 95% confidence intervals, and P-values, representing standard deviation change in CMR metrics associated with hypertension (vs. no hypertension). Models include adjustment for age, sex, ethnicity, deprivation, alcohol, body mass index, smoking, diabetes, and high cholesterol.

CMR, cardiovascular magnetic resonance; i, indexed to body surface area; LAVi, maximum left atrial volume; LAEF, left atrial ejection fraction; LVEDVi, left ventricular end-diastolic volume; LVSVi, left ventricular stroke volume; LVMi, left ventricular mass; LVM/LVEDV, left ventricular mass to volume ratio; WT, wall thickness; LVEF, left ventricular ejection fraction; LVGFI, left ventricular global function index; GLS, Global Longitudinal Strain; AoD, aortic distensibility.

significant P-value after multiple testing adjustment.

Table 2
Open in new tab

Associations of hypertension with CMR metrics in fully adjusted linear regression models stratified by sex

Whole sampleWomenMenHypertension × sex interaction
LAVi0.159* [0.130, 0.188]0.142* [0.105, 0.180]0.176* [0.132, 0.220]0.050 [−0.002, 0.103]
3.81 × 10−271.60 × 10−135.26 × 10−150.0617
LAEF−0.117* [−0.146, −0.089]−0.124* [−0.162, −0.086]−0.108* [−0.151, −0.065]−0.017 [−0.069, 0.035]
1.08 × 10−151.52 × 10−109.77 × 10−70.5218
LVEDVi0.101* [0.077, 0.125]0.088* [0.060, 0.116]0.119* [0.080, 0.157]−0.020 [−0.063, 0.024]
8.31 × 10−171.36 × 10−91.29 × 10−90.3741
LVSVi0.113* [0.088, 0.138]0.109* [0.077, 0.141]0.121* [0.082, 0.160]−0.037 [−0.082, 0.009]
1.42 × 10−181.61 × 10−111.42 × 10−90.1149
LVMi0.258* [0.238, 0.279]0.238* [0.213, 0.262]0.283* [0.250, 0.316]0.005 [−0.032, 0.042]
2.20 × 10−1332.70 × 10−802.74 × 10−620.7873
LVM/LVEDV0.200* [0.177, 0.223]0.206* [0.177, 0.235]0.193* [0.157, 0.228]−0.003 [−0.045, 0.039]
2.21 × 10−645.16 × 10−447.70 × 10−260.8788
Maximal WT0.240* [0.219, 0.261]0.243* [0.217, 0.269]0.236* [0.203, 0.269]−0.001 [−0.039, 0.038]
8.51 × 10−1102.40 × 10−731.37 × 10−440.9759
LVEF0.038* [0.013, 0.063]0.048* [0.014, 0.082]0.029 [−0.008, 0.067]−0.030 [−0.076, 0.017]
0.00320.00570.12740.2097
LV GFI−0.057* [−0.081, −0.033]−0.058* [−0.092, −0.024]−0.056* [−0.090, −0.023]0.003 [−0.040, 0.047]
2.66 × 10−67.61 × 10−40.00110.8881
GLS0.049* [0.021, 0.077]0.042 [0.002, 0.082]0.055* [0.015, 0.095]0.025 [−0.027, 0.076]
6.91 × 10−40.03940.00690.3475
Native T1−0.060* [−0.081, −0.038]−0.117* [−0.148, −0.087]−0.008 [−0.038, 0.023]0.210* [0.170, 0.249]
5.91 × 10−84.07 × 10−140.62431.17 × 10−25
AoD−0.174* [−0.194, −0.153]−0.199* [−0.228, −0.169]−0.146* [−0.174, −0.119]0.076* [0.039, 0.113]
2.38 × 10−624.54 × 10−392.39 × 10−256.46 × 10−5
Whole sampleWomenMenHypertension × sex interaction
LAVi0.159* [0.130, 0.188]0.142* [0.105, 0.180]0.176* [0.132, 0.220]0.050 [−0.002, 0.103]
3.81 × 10−271.60 × 10−135.26 × 10−150.0617
LAEF−0.117* [−0.146, −0.089]−0.124* [−0.162, −0.086]−0.108* [−0.151, −0.065]−0.017 [−0.069, 0.035]
1.08 × 10−151.52 × 10−109.77 × 10−70.5218
LVEDVi0.101* [0.077, 0.125]0.088* [0.060, 0.116]0.119* [0.080, 0.157]−0.020 [−0.063, 0.024]
8.31 × 10−171.36 × 10−91.29 × 10−90.3741
LVSVi0.113* [0.088, 0.138]0.109* [0.077, 0.141]0.121* [0.082, 0.160]−0.037 [−0.082, 0.009]
1.42 × 10−181.61 × 10−111.42 × 10−90.1149
LVMi0.258* [0.238, 0.279]0.238* [0.213, 0.262]0.283* [0.250, 0.316]0.005 [−0.032, 0.042]
2.20 × 10−1332.70 × 10−802.74 × 10−620.7873
LVM/LVEDV0.200* [0.177, 0.223]0.206* [0.177, 0.235]0.193* [0.157, 0.228]−0.003 [−0.045, 0.039]
2.21 × 10−645.16 × 10−447.70 × 10−260.8788
Maximal WT0.240* [0.219, 0.261]0.243* [0.217, 0.269]0.236* [0.203, 0.269]−0.001 [−0.039, 0.038]
8.51 × 10−1102.40 × 10−731.37 × 10−440.9759
LVEF0.038* [0.013, 0.063]0.048* [0.014, 0.082]0.029 [−0.008, 0.067]−0.030 [−0.076, 0.017]
0.00320.00570.12740.2097
LV GFI−0.057* [−0.081, −0.033]−0.058* [−0.092, −0.024]−0.056* [−0.090, −0.023]0.003 [−0.040, 0.047]
2.66 × 10−67.61 × 10−40.00110.8881
GLS0.049* [0.021, 0.077]0.042 [0.002, 0.082]0.055* [0.015, 0.095]0.025 [−0.027, 0.076]
6.91 × 10−40.03940.00690.3475
Native T1−0.060* [−0.081, −0.038]−0.117* [−0.148, −0.087]−0.008 [−0.038, 0.023]0.210* [0.170, 0.249]
5.91 × 10−84.07 × 10−140.62431.17 × 10−25
AoD−0.174* [−0.194, −0.153]−0.199* [−0.228, −0.169]−0.146* [−0.174, −0.119]0.076* [0.039, 0.113]
2.38 × 10−624.54 × 10−392.39 × 10−256.46 × 10−5

Results are standardised Beta coefficients, 95% confidence intervals, and P-values, representing standard deviation change in CMR metrics associated with hypertension (vs. no hypertension). Models include adjustment for age, sex, ethnicity, deprivation, alcohol, body mass index, smoking, diabetes, and high cholesterol.

CMR, cardiovascular magnetic resonance; i, indexed to body surface area; LAVi, maximum left atrial volume; LAEF, left atrial ejection fraction; LVEDVi, left ventricular end-diastolic volume; LVSVi, left ventricular stroke volume; LVMi, left ventricular mass; LVM/LVEDV, left ventricular mass to volume ratio; WT, wall thickness; LVEF, left ventricular ejection fraction; LVGFI, left ventricular global function index; GLS, Global Longitudinal Strain; AoD, aortic distensibility.

significant P-value after multiple testing adjustment.

Close
This Feature Is Available To Subscribers Only

Sign In or Create an Account

Close

This PDF is available to Subscribers Only

View Article Abstract & Purchase Options

For full access to this pdf, sign in to an existing account, or purchase an annual subscription.

Close