Table 2 Open in new tab Multivariate Cox...

Table 2

Multivariate Cox proportional hazards models for all-cause death or HF hospitalization, all-cause death, and HF hospitalization

	No. of events (%)	Age- and sex-adjusted HR (95% CI)	P-value	Adjusted* HR (95% CI)	P-value
All-cause death or HF Hospitalization
Eplerenone	95 (15%)	0.86 (0.70–1.06)	0.17	1.02 (0.82–1.27)	0.86
Spironolactone	1263 (18%)	1.00 (ref.)		1.00 (ref.)
All-cause death
Eplerenone	38 (6%)	0.87 (0.62–1.21)	0.41	0.93 (0.67–1.30)	0.68
Spironolactone	579 (8%)	1.00 (ref.)		1.00 (ref.)
HF hospitalization
Eplerenone	66 (10%)	0.87 (0.68–1.13)	0.30	1.10 (0.84–1.42)	0.50
Spironolactone	802 (12%)	1.00 (ref.)		1.00 (ref.)

	No. of events (%)	Age- and sex-adjusted HR (95% CI)	P-value	Adjusted* HR (95% CI)	P-value
All-cause death or HF Hospitalization
Eplerenone	95 (15%)	0.86 (0.70–1.06)	0.17	1.02 (0.82–1.27)	0.86
Spironolactone	1263 (18%)	1.00 (ref.)		1.00 (ref.)
All-cause death
Eplerenone	38 (6%)	0.87 (0.62–1.21)	0.41	0.93 (0.67–1.30)	0.68
Spironolactone	579 (8%)	1.00 (ref.)		1.00 (ref.)
HF hospitalization
Eplerenone	66 (10%)	0.87 (0.68–1.13)	0.30	1.10 (0.84–1.42)	0.50
Spironolactone	802 (12%)	1.00 (ref.)		1.00 (ref.)

Abbreviations: HR = Hazard Ratio; CI = confidence interval

Adjusted for age, sex, ischemic heart disease, chronic obstructive pulmonary disease, diabetes, chronic kidney disease, cancer, readmission for heart failure, loop diuretics, and reimbursement status for eplerenone.

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