Multivariable-Adjusted Odds Ratios for Osteoporosis According to gSOS PRS Quintile
| . | Analysis, OR (95% CI) a; P Value . | ||
|---|---|---|---|
| . | Primary b . | Sensitivity: Control c . | Sensitivity: Case d . |
| Normal BMD e | Controls (n = 289) | Controls (n = 623) | Controls (n = 289) |
| Osteopenia f | Excluded (n = 334) | Cases (n = 483) | |
| Osteoporosis g | Cases (n = 149) | Cases (n = 149) | |
| gSOS PRS quintile vs first | |||
| Second | 2.53 (1.11–5.75); 0.027 | 1.63 (.81–3.26); .171 | 1.26 (.78–2.04); .349 |
| Third | 2.88 (1.27–6.55); .011 | 2.41 (1.23–4.73); .010 | 1.57 (.97–2.55); .066 |
| Fourth | 2.70 (1.20–6.03); .016 | 2.05 (1.05–3.99); .035 | 1.36 (.83–2.22); .217 |
| Fifth | 4.13 (1.86–9.18); < .001 | 2.34 (1.20–4.57); .013 | 2.30 (1.37–3.88); .002 |
| . | Analysis, OR (95% CI) a; P Value . | ||
|---|---|---|---|
| . | Primary b . | Sensitivity: Control c . | Sensitivity: Case d . |
| Normal BMD e | Controls (n = 289) | Controls (n = 623) | Controls (n = 289) |
| Osteopenia f | Excluded (n = 334) | Cases (n = 483) | |
| Osteoporosis g | Cases (n = 149) | Cases (n = 149) | |
| gSOS PRS quintile vs first | |||
| Second | 2.53 (1.11–5.75); 0.027 | 1.63 (.81–3.26); .171 | 1.26 (.78–2.04); .349 |
| Third | 2.88 (1.27–6.55); .011 | 2.41 (1.23–4.73); .010 | 1.57 (.97–2.55); .066 |
| Fourth | 2.70 (1.20–6.03); .016 | 2.05 (1.05–3.99); .035 | 1.36 (.83–2.22); .217 |
| Fifth | 4.13 (1.86–9.18); < .001 | 2.34 (1.20–4.57); .013 | 2.30 (1.37–3.88); .002 |
Abbreviations: BMD, bone mineral density; gSOS, genetically predicted heel quantitative ultrasound speed of sound; OR, odds ratio; PRS, polygenic risk score.
All odds ratios are adjusted for traditional and HIV-related risk factors, including antiretrovirals.
Primary analysis: cases are defined as any T-score ≤ −2.5 or Z-score ≤ −2 in premenopausal women or men aged <50 years and with controls defined as all T-scores > −1.0.
Sensitivity analysis with controls defined as all T-scores > −2.5.
Sensitivity analysis with cases defined as any T-score ≤ −1.0 or Z-score ≤ −2 in premenopausal women or men aged <50 years.
T-score > −1.0.
T-score ≤ −1.0 and > −2.5.
T-score ≤ −2.5 or Z-score ≤ −2 in premenopausal women or men aged <50 years.
Multivariable-Adjusted Odds Ratios for Osteoporosis According to gSOS PRS Quintile
| . | Analysis, OR (95% CI) a; P Value . | ||
|---|---|---|---|
| . | Primary b . | Sensitivity: Control c . | Sensitivity: Case d . |
| Normal BMD e | Controls (n = 289) | Controls (n = 623) | Controls (n = 289) |
| Osteopenia f | Excluded (n = 334) | Cases (n = 483) | |
| Osteoporosis g | Cases (n = 149) | Cases (n = 149) | |
| gSOS PRS quintile vs first | |||
| Second | 2.53 (1.11–5.75); 0.027 | 1.63 (.81–3.26); .171 | 1.26 (.78–2.04); .349 |
| Third | 2.88 (1.27–6.55); .011 | 2.41 (1.23–4.73); .010 | 1.57 (.97–2.55); .066 |
| Fourth | 2.70 (1.20–6.03); .016 | 2.05 (1.05–3.99); .035 | 1.36 (.83–2.22); .217 |
| Fifth | 4.13 (1.86–9.18); < .001 | 2.34 (1.20–4.57); .013 | 2.30 (1.37–3.88); .002 |
| . | Analysis, OR (95% CI) a; P Value . | ||
|---|---|---|---|
| . | Primary b . | Sensitivity: Control c . | Sensitivity: Case d . |
| Normal BMD e | Controls (n = 289) | Controls (n = 623) | Controls (n = 289) |
| Osteopenia f | Excluded (n = 334) | Cases (n = 483) | |
| Osteoporosis g | Cases (n = 149) | Cases (n = 149) | |
| gSOS PRS quintile vs first | |||
| Second | 2.53 (1.11–5.75); 0.027 | 1.63 (.81–3.26); .171 | 1.26 (.78–2.04); .349 |
| Third | 2.88 (1.27–6.55); .011 | 2.41 (1.23–4.73); .010 | 1.57 (.97–2.55); .066 |
| Fourth | 2.70 (1.20–6.03); .016 | 2.05 (1.05–3.99); .035 | 1.36 (.83–2.22); .217 |
| Fifth | 4.13 (1.86–9.18); < .001 | 2.34 (1.20–4.57); .013 | 2.30 (1.37–3.88); .002 |
Abbreviations: BMD, bone mineral density; gSOS, genetically predicted heel quantitative ultrasound speed of sound; OR, odds ratio; PRS, polygenic risk score.
All odds ratios are adjusted for traditional and HIV-related risk factors, including antiretrovirals.
Primary analysis: cases are defined as any T-score ≤ −2.5 or Z-score ≤ −2 in premenopausal women or men aged <50 years and with controls defined as all T-scores > −1.0.
Sensitivity analysis with controls defined as all T-scores > −2.5.
Sensitivity analysis with cases defined as any T-score ≤ −1.0 or Z-score ≤ −2 in premenopausal women or men aged <50 years.
T-score > −1.0.
T-score ≤ −1.0 and > −2.5.
T-score ≤ −2.5 or Z-score ≤ −2 in premenopausal women or men aged <50 years.
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