Multivariate Cox analysis showed mutation in MLH3, NOTCH1, and TSC2 as well as signature 1 as independent prognostic markers of poor prognosis.
| Covariate . | HR . | 95% CI . | P-value . |
|---|---|---|---|
| MLH3 mutation | 29.03 | 5.90-142.79 | .00003 |
| NACA mutation | 0.10 | 0.00-14.30 | .36744 |
| NOTCH1 mutation | 6.64 | 1.76-24.99 | .00512 |
| NPAP1 mutation | 19.73 | 0.22-1.78e+03 | .19444 |
| RANBP17 mutation | 0.10 | 0.00-14.30 | .36744 |
| TSC2 mutation | 246.20 | 1.33-4.57e+04 | .03884 |
| ZFHX4 mutation | 4.84 | 0.57-41.44 | .14996 |
| Signature 1 | 13.87 | 1.48-130.04 | .0213 |
| Covariate . | HR . | 95% CI . | P-value . |
|---|---|---|---|
| MLH3 mutation | 29.03 | 5.90-142.79 | .00003 |
| NACA mutation | 0.10 | 0.00-14.30 | .36744 |
| NOTCH1 mutation | 6.64 | 1.76-24.99 | .00512 |
| NPAP1 mutation | 19.73 | 0.22-1.78e+03 | .19444 |
| RANBP17 mutation | 0.10 | 0.00-14.30 | .36744 |
| TSC2 mutation | 246.20 | 1.33-4.57e+04 | .03884 |
| ZFHX4 mutation | 4.84 | 0.57-41.44 | .14996 |
| Signature 1 | 13.87 | 1.48-130.04 | .0213 |
The significance of bold value is P value <.05.
Abbreviation: HR, hazard ratio.
Multivariate Cox analysis showed mutation in MLH3, NOTCH1, and TSC2 as well as signature 1 as independent prognostic markers of poor prognosis.
| Covariate . | HR . | 95% CI . | P-value . |
|---|---|---|---|
| MLH3 mutation | 29.03 | 5.90-142.79 | .00003 |
| NACA mutation | 0.10 | 0.00-14.30 | .36744 |
| NOTCH1 mutation | 6.64 | 1.76-24.99 | .00512 |
| NPAP1 mutation | 19.73 | 0.22-1.78e+03 | .19444 |
| RANBP17 mutation | 0.10 | 0.00-14.30 | .36744 |
| TSC2 mutation | 246.20 | 1.33-4.57e+04 | .03884 |
| ZFHX4 mutation | 4.84 | 0.57-41.44 | .14996 |
| Signature 1 | 13.87 | 1.48-130.04 | .0213 |
| Covariate . | HR . | 95% CI . | P-value . |
|---|---|---|---|
| MLH3 mutation | 29.03 | 5.90-142.79 | .00003 |
| NACA mutation | 0.10 | 0.00-14.30 | .36744 |
| NOTCH1 mutation | 6.64 | 1.76-24.99 | .00512 |
| NPAP1 mutation | 19.73 | 0.22-1.78e+03 | .19444 |
| RANBP17 mutation | 0.10 | 0.00-14.30 | .36744 |
| TSC2 mutation | 246.20 | 1.33-4.57e+04 | .03884 |
| ZFHX4 mutation | 4.84 | 0.57-41.44 | .14996 |
| Signature 1 | 13.87 | 1.48-130.04 | .0213 |
The significance of bold value is P value <.05.
Abbreviation: HR, hazard ratio.
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