LV function in patients who had persistent cardiotoxicity after trastuzumab completion or discontinuation.
ID . | Age . | Baseline GLS . | Nadir GLS . | GLS at final follow-up . | Baseline LVEF . | Nadir LVEF . | LVEF at final follow-up . | Worst NYHA . | Follow-up (days) . | Pre-existing cardio-myopathy . | Discontinued trastuzumab prematurely due to cDLT . |
---|---|---|---|---|---|---|---|---|---|---|---|
16 | 62 | −21.8 | −15 | −16.9 | 58 | 50 | 51 | I | 155 | No | No |
23 | 65 | −17.8 | −6.8 | −12.9 | 58 | 26 | 58 | III | 1416 | No | Yes |
28 | 68 | −20.2 | −14.1 | −14.9 | 58 | 50 | 53 | I | 602 | No | No |
37 | 41 | N/A | −12.4 | −16.6 | 58 | 45 | 47 | II | 759 | No | No |
38 | 64 | −21.8 | 11.5 | −16.7 | 61 | 38 | 53 | I | 974 | No | No |
39 | 69 | N/A | −14.1 | −14.2 | 60 | 45 | 49 | I | 155 | No | No |
43 | 65 | −22.6 | −16.9 | −16.9 | 67 | 45 | 56 | II | 256 | No | Yes |
ID . | Age . | Baseline GLS . | Nadir GLS . | GLS at final follow-up . | Baseline LVEF . | Nadir LVEF . | LVEF at final follow-up . | Worst NYHA . | Follow-up (days) . | Pre-existing cardio-myopathy . | Discontinued trastuzumab prematurely due to cDLT . |
---|---|---|---|---|---|---|---|---|---|---|---|
16 | 62 | −21.8 | −15 | −16.9 | 58 | 50 | 51 | I | 155 | No | No |
23 | 65 | −17.8 | −6.8 | −12.9 | 58 | 26 | 58 | III | 1416 | No | Yes |
28 | 68 | −20.2 | −14.1 | −14.9 | 58 | 50 | 53 | I | 602 | No | No |
37 | 41 | N/A | −12.4 | −16.6 | 58 | 45 | 47 | II | 759 | No | No |
38 | 64 | −21.8 | 11.5 | −16.7 | 61 | 38 | 53 | I | 974 | No | No |
39 | 69 | N/A | −14.1 | −14.2 | 60 | 45 | 49 | I | 155 | No | No |
43 | 65 | −22.6 | −16.9 | −16.9 | 67 | 45 | 56 | II | 256 | No | Yes |
LV function in patients who had persistent cardiotoxicity after trastuzumab completion or discontinuation.
ID . | Age . | Baseline GLS . | Nadir GLS . | GLS at final follow-up . | Baseline LVEF . | Nadir LVEF . | LVEF at final follow-up . | Worst NYHA . | Follow-up (days) . | Pre-existing cardio-myopathy . | Discontinued trastuzumab prematurely due to cDLT . |
---|---|---|---|---|---|---|---|---|---|---|---|
16 | 62 | −21.8 | −15 | −16.9 | 58 | 50 | 51 | I | 155 | No | No |
23 | 65 | −17.8 | −6.8 | −12.9 | 58 | 26 | 58 | III | 1416 | No | Yes |
28 | 68 | −20.2 | −14.1 | −14.9 | 58 | 50 | 53 | I | 602 | No | No |
37 | 41 | N/A | −12.4 | −16.6 | 58 | 45 | 47 | II | 759 | No | No |
38 | 64 | −21.8 | 11.5 | −16.7 | 61 | 38 | 53 | I | 974 | No | No |
39 | 69 | N/A | −14.1 | −14.2 | 60 | 45 | 49 | I | 155 | No | No |
43 | 65 | −22.6 | −16.9 | −16.9 | 67 | 45 | 56 | II | 256 | No | Yes |
ID . | Age . | Baseline GLS . | Nadir GLS . | GLS at final follow-up . | Baseline LVEF . | Nadir LVEF . | LVEF at final follow-up . | Worst NYHA . | Follow-up (days) . | Pre-existing cardio-myopathy . | Discontinued trastuzumab prematurely due to cDLT . |
---|---|---|---|---|---|---|---|---|---|---|---|
16 | 62 | −21.8 | −15 | −16.9 | 58 | 50 | 51 | I | 155 | No | No |
23 | 65 | −17.8 | −6.8 | −12.9 | 58 | 26 | 58 | III | 1416 | No | Yes |
28 | 68 | −20.2 | −14.1 | −14.9 | 58 | 50 | 53 | I | 602 | No | No |
37 | 41 | N/A | −12.4 | −16.6 | 58 | 45 | 47 | II | 759 | No | No |
38 | 64 | −21.8 | 11.5 | −16.7 | 61 | 38 | 53 | I | 974 | No | No |
39 | 69 | N/A | −14.1 | −14.2 | 60 | 45 | 49 | I | 155 | No | No |
43 | 65 | −22.6 | −16.9 | −16.9 | 67 | 45 | 56 | II | 256 | No | Yes |
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