Table 1
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Baseline characteristics

Age, years73 ± 11
Men605 (66.4%)
Systolic blood pressure at study entry139 ± 28
Hypertension678 (74.4%)
Current smoking77 (8.5%)
Diabetes mellitus220 (24.1%)
Heart failure343 (37.7%)
Peripheral arterial disease92 (10.1%)
History of stroke or TIA103 (11.3%)
Coronary artery disease127 (13.9%)
COPD183 (20.1%)
CHA2DS2-VASc
 = 062 (6.8%)
 ≥ 1849 (93.2%)
 ≥ 2772 (84.7%)
History of malignancy135 (14.8%)
HAS-BLED
047 (5.2%)
1160 (17.6%)
2365 (40.1%)
3261 (28.6%)
469 (7.6%)
56 (0.7%)
63 (0.3%)
Alcohol consumption ≥40 g/daily81 (8.9%)
Prior bleeding115 (12.6%)
Thyroid disorder:
 Hyperthyroidism14 (1.5%)
 Hyporthyroidism79 (8.7%)
Anaemia178 (19.5%)
eGFR < 30 mL/min/1.73m236 (4%)
Abnormal liver functiona9 (1%)
PINRR58% ± 18%
Age, years73 ± 11
Men605 (66.4%)
Systolic blood pressure at study entry139 ± 28
Hypertension678 (74.4%)
Current smoking77 (8.5%)
Diabetes mellitus220 (24.1%)
Heart failure343 (37.7%)
Peripheral arterial disease92 (10.1%)
History of stroke or TIA103 (11.3%)
Coronary artery disease127 (13.9%)
COPD183 (20.1%)
CHA2DS2-VASc
 = 062 (6.8%)
 ≥ 1849 (93.2%)
 ≥ 2772 (84.7%)
History of malignancy135 (14.8%)
HAS-BLED
047 (5.2%)
1160 (17.6%)
2365 (40.1%)
3261 (28.6%)
469 (7.6%)
56 (0.7%)
63 (0.3%)
Alcohol consumption ≥40 g/daily81 (8.9%)
Prior bleeding115 (12.6%)
Thyroid disorder:
 Hyperthyroidism14 (1.5%)
 Hyporthyroidism79 (8.7%)
Anaemia178 (19.5%)
eGFR < 30 mL/min/1.73m236 (4%)
Abnormal liver functiona9 (1%)
PINRR58% ± 18%

CHA2DS2-VASc indicates congestive heart failure, hypertension, age ≥ 75, diabetes mellitus, stroke, vascular disease, female sex category; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; HAS-BLED, uncontrolled Hypertension: systolic >160 mmHg, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly > 65 years, Drugs/alcohol concomitantly; TIA, transient ischaemic attack. PINRR, percentage of INRs in therapeutic range.

aDefined as cirrhosis or elevated liver transaminases enzymes >3 times higher than the upper limit of normal and elevated total bilirubin >2 times higher than the upper limit of normal.

Table 1
Open in new tab

Baseline characteristics

Age, years73 ± 11
Men605 (66.4%)
Systolic blood pressure at study entry139 ± 28
Hypertension678 (74.4%)
Current smoking77 (8.5%)
Diabetes mellitus220 (24.1%)
Heart failure343 (37.7%)
Peripheral arterial disease92 (10.1%)
History of stroke or TIA103 (11.3%)
Coronary artery disease127 (13.9%)
COPD183 (20.1%)
CHA2DS2-VASc
 = 062 (6.8%)
 ≥ 1849 (93.2%)
 ≥ 2772 (84.7%)
History of malignancy135 (14.8%)
HAS-BLED
047 (5.2%)
1160 (17.6%)
2365 (40.1%)
3261 (28.6%)
469 (7.6%)
56 (0.7%)
63 (0.3%)
Alcohol consumption ≥40 g/daily81 (8.9%)
Prior bleeding115 (12.6%)
Thyroid disorder:
 Hyperthyroidism14 (1.5%)
 Hyporthyroidism79 (8.7%)
Anaemia178 (19.5%)
eGFR < 30 mL/min/1.73m236 (4%)
Abnormal liver functiona9 (1%)
PINRR58% ± 18%
Age, years73 ± 11
Men605 (66.4%)
Systolic blood pressure at study entry139 ± 28
Hypertension678 (74.4%)
Current smoking77 (8.5%)
Diabetes mellitus220 (24.1%)
Heart failure343 (37.7%)
Peripheral arterial disease92 (10.1%)
History of stroke or TIA103 (11.3%)
Coronary artery disease127 (13.9%)
COPD183 (20.1%)
CHA2DS2-VASc
 = 062 (6.8%)
 ≥ 1849 (93.2%)
 ≥ 2772 (84.7%)
History of malignancy135 (14.8%)
HAS-BLED
047 (5.2%)
1160 (17.6%)
2365 (40.1%)
3261 (28.6%)
469 (7.6%)
56 (0.7%)
63 (0.3%)
Alcohol consumption ≥40 g/daily81 (8.9%)
Prior bleeding115 (12.6%)
Thyroid disorder:
 Hyperthyroidism14 (1.5%)
 Hyporthyroidism79 (8.7%)
Anaemia178 (19.5%)
eGFR < 30 mL/min/1.73m236 (4%)
Abnormal liver functiona9 (1%)
PINRR58% ± 18%

CHA2DS2-VASc indicates congestive heart failure, hypertension, age ≥ 75, diabetes mellitus, stroke, vascular disease, female sex category; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate; HAS-BLED, uncontrolled Hypertension: systolic >160 mmHg, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly > 65 years, Drugs/alcohol concomitantly; TIA, transient ischaemic attack. PINRR, percentage of INRs in therapeutic range.

aDefined as cirrhosis or elevated liver transaminases enzymes >3 times higher than the upper limit of normal and elevated total bilirubin >2 times higher than the upper limit of normal.

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