Table 1. Open in new tab Efficacy rate,...

Scenario	2-dose	3-dose
Efficacy rate	0.20	0.20	0.40	0.40	0.22	0.40	0.20	0.20	0.20	0.39	0.40	0.41	0.20	0.40	0.40	0.20	0.26	0.40
Toxicity rate	0.30	0.30	0.13	0.29	0.13	0.26	0.30	0.30	0.30	0.11	0.28	0.30	0.11	0.18	0.30	0.24	0.25	0.30
Hazard ratio	1.00	1.00	0.64	0.64	0.97	0.64	1.00	1.00	1.00	0.64	0.63	0.62	0.95	0.64	0.62	0.96	0.79	0.64

Scenario	2-dose	3-dose
Efficacy rate	0.20	0.20	0.40	0.40	0.22	0.40	0.20	0.20	0.20	0.39	0.40	0.41	0.20	0.40	0.40	0.20	0.26	0.40
Toxicity rate	0.30	0.30	0.13	0.29	0.13	0.26	0.30	0.30	0.30	0.11	0.28	0.30	0.11	0.18	0.30	0.24	0.25	0.30
Hazard ratio	1.00	1.00	0.64	0.64	0.97	0.64	1.00	1.00	1.00	0.64	0.63	0.62	0.95	0.64	0.62	0.96	0.79	0.64

Table 1.

Efficacy rate, toxicity rate, and hazard ratio for 2-dose and 3-dose scenarios^a

Scenario	2-dose						3-dose
Scenario	0		1		2		0			1			2			3
Dose	1	2	1	2	1	2	1	2	3	1	2	3	1	2	3	1	2	3
Efficacy rate	0.20	0.20	0.40	0.40	0.22	0.40	0.20	0.20	0.20	0.39	0.40	0.41	0.20	0.40	0.40	0.20	0.26	0.40
Toxicity rate	0.30	0.30	0.13	0.29	0.13	0.26	0.30	0.30	0.30	0.11	0.28	0.30	0.11	0.18	0.30	0.24	0.25	0.30
Hazard ratio	1.00	1.00	0.64	0.64	0.97	0.64	1.00	1.00	1.00	0.64	0.63	0.62	0.95	0.64	0.62	0.96	0.79	0.64

Scenario	2-dose						3-dose
Scenario	0		1		2		0			1			2			3
Dose	1	2	1	2	1	2	1	2	3	1	2	3	1	2	3	1	2	3
Efficacy rate	0.20	0.20	0.40	0.40	0.22	0.40	0.20	0.20	0.20	0.39	0.40	0.41	0.20	0.40	0.40	0.20	0.26	0.40
Toxicity rate	0.30	0.30	0.13	0.29	0.13	0.26	0.30	0.30	0.30	0.11	0.28	0.30	0.11	0.18	0.30	0.24	0.25	0.30
Hazard ratio	1.00	1.00	0.64	0.64	0.97	0.64	1.00	1.00	1.00	0.64	0.63	0.62	0.95	0.64	0.62	0.96	0.79	0.64

Scenario 0 represents a null case where all doses are ineffective and thus has no optimal dose. In 2-dose scenarios, scenarios 1 and 2 represent the optimal doses are doses 1 and 2, respectively; and in 3-dose scenarios, scenarios 1-3 represent the optimal doses are doses 1-3, respectively. The optimal dose is indicated in boldface.

This Feature Is Available To Subscribers Only