Modelled change compared to baseline exam in CMTES and CMTES-R over time by categorical MMRM
| Year . | CMTES change from baseline . | 95% CI . | P-value . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| 1 | 0.24 | −1.13 | 1.61 | 0.74 |
| 2 | 1.14 | −0.40 | 2.68 | 0.15 |
| 3 | 2.11 | 0.48 | 3.74 | 0.01 |
| 4 | 2.1 | 0.44 | 3.76 | 0.01 |
| 5 | 2.61 | 0.81 | 4.41 | 0.006 |
| 6 | 3.14 | 1.19 | 5.09 | 0.002 |
| Year | CMTES-R change from baseline | 95% CI | P-value | |
| Lower | Upper | |||
| 1 | 0.32 | −1.32 | 1.96 | 0.71 |
| 2 | 1.47 | −0.37 | 3.31 | 0.12 |
| 3 | 2.08 | 0.13 | 4.03 | 0.04 |
| 4 | 2.74 | 0.76 | 4.72 | 0.009 |
| 5 | 3.13 | 0.98 | 5.28 | 0.006 |
| 6 | 3.46 | 1.20 | 5.72 | 0.004 |
| Year . | CMTES change from baseline . | 95% CI . | P-value . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| 1 | 0.24 | −1.13 | 1.61 | 0.74 |
| 2 | 1.14 | −0.40 | 2.68 | 0.15 |
| 3 | 2.11 | 0.48 | 3.74 | 0.01 |
| 4 | 2.1 | 0.44 | 3.76 | 0.01 |
| 5 | 2.61 | 0.81 | 4.41 | 0.006 |
| 6 | 3.14 | 1.19 | 5.09 | 0.002 |
| Year | CMTES-R change from baseline | 95% CI | P-value | |
| Lower | Upper | |||
| 1 | 0.32 | −1.32 | 1.96 | 0.71 |
| 2 | 1.47 | −0.37 | 3.31 | 0.12 |
| 3 | 2.08 | 0.13 | 4.03 | 0.04 |
| 4 | 2.74 | 0.76 | 4.72 | 0.009 |
| 5 | 3.13 | 0.98 | 5.28 | 0.006 |
| 6 | 3.46 | 1.20 | 5.72 | 0.004 |
A mixed models for repeated measures (MMRM) analysis using categorical time showing change in CMTES and CMTES-R at each year after baseline over 6 years. Significant difference in the mean CMTES and mean CMTES-R was seen beginning at 3 years after baseline exam. Bolded text indicates statistically significant change from baseline (P < 0.05).
Modelled change compared to baseline exam in CMTES and CMTES-R over time by categorical MMRM
| Year . | CMTES change from baseline . | 95% CI . | P-value . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| 1 | 0.24 | −1.13 | 1.61 | 0.74 |
| 2 | 1.14 | −0.40 | 2.68 | 0.15 |
| 3 | 2.11 | 0.48 | 3.74 | 0.01 |
| 4 | 2.1 | 0.44 | 3.76 | 0.01 |
| 5 | 2.61 | 0.81 | 4.41 | 0.006 |
| 6 | 3.14 | 1.19 | 5.09 | 0.002 |
| Year | CMTES-R change from baseline | 95% CI | P-value | |
| Lower | Upper | |||
| 1 | 0.32 | −1.32 | 1.96 | 0.71 |
| 2 | 1.47 | −0.37 | 3.31 | 0.12 |
| 3 | 2.08 | 0.13 | 4.03 | 0.04 |
| 4 | 2.74 | 0.76 | 4.72 | 0.009 |
| 5 | 3.13 | 0.98 | 5.28 | 0.006 |
| 6 | 3.46 | 1.20 | 5.72 | 0.004 |
| Year . | CMTES change from baseline . | 95% CI . | P-value . | |
|---|---|---|---|---|
| Lower . | Upper . | |||
| 1 | 0.24 | −1.13 | 1.61 | 0.74 |
| 2 | 1.14 | −0.40 | 2.68 | 0.15 |
| 3 | 2.11 | 0.48 | 3.74 | 0.01 |
| 4 | 2.1 | 0.44 | 3.76 | 0.01 |
| 5 | 2.61 | 0.81 | 4.41 | 0.006 |
| 6 | 3.14 | 1.19 | 5.09 | 0.002 |
| Year | CMTES-R change from baseline | 95% CI | P-value | |
| Lower | Upper | |||
| 1 | 0.32 | −1.32 | 1.96 | 0.71 |
| 2 | 1.47 | −0.37 | 3.31 | 0.12 |
| 3 | 2.08 | 0.13 | 4.03 | 0.04 |
| 4 | 2.74 | 0.76 | 4.72 | 0.009 |
| 5 | 3.13 | 0.98 | 5.28 | 0.006 |
| 6 | 3.46 | 1.20 | 5.72 | 0.004 |
A mixed models for repeated measures (MMRM) analysis using categorical time showing change in CMTES and CMTES-R at each year after baseline over 6 years. Significant difference in the mean CMTES and mean CMTES-R was seen beginning at 3 years after baseline exam. Bolded text indicates statistically significant change from baseline (P < 0.05).
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