Correlations of a subset of significantly altered proteins with clinical measures of activity and disease in JDM patients
| Protein name . | Gene . | Clinical measure . | r . | P-value . |
|---|---|---|---|---|
| Cathepsin D | CTSD | MDI muscle damage | 0.57 | P < 0.05 |
| CMAS | −0.54 | P < 0.05 | ||
| MDAAT pulmonary | −0.54 | P < 0.05 | ||
| Collagen alpha-1(II) chain | COL2A1 | MD global disease damage | 0.48 | P < 0.05 |
| MDI total severity | 0.64 | P < 0.05 | ||
| CMAS | −0.60 | P < 0.05 | ||
| DAS muscle | 0.53 | P < 0.05 | ||
| Collagen alpha-1(I) chain | COL1A1 | AST | 0.46 | P < 0.05 |
| DAS muscle | 0.55 | P < 0.05 | ||
| MDAAT cardiovascular | −0.70 | P < 0.01 | ||
| Collagen alpha-1(XII) chain | COL12A1 | AST | 0.51 | P < 0.05 |
| Ly6/neurotoxin-like protein 1 | LYNX1 | Aldolase | −0.52 | P < 0.05 |
| Protein name . | Gene . | Clinical measure . | r . | P-value . |
|---|---|---|---|---|
| Cathepsin D | CTSD | MDI muscle damage | 0.57 | P < 0.05 |
| CMAS | −0.54 | P < 0.05 | ||
| MDAAT pulmonary | −0.54 | P < 0.05 | ||
| Collagen alpha-1(II) chain | COL2A1 | MD global disease damage | 0.48 | P < 0.05 |
| MDI total severity | 0.64 | P < 0.05 | ||
| CMAS | −0.60 | P < 0.05 | ||
| DAS muscle | 0.53 | P < 0.05 | ||
| Collagen alpha-1(I) chain | COL1A1 | AST | 0.46 | P < 0.05 |
| DAS muscle | 0.55 | P < 0.05 | ||
| MDAAT cardiovascular | −0.70 | P < 0.01 | ||
| Collagen alpha-1(XII) chain | COL12A1 | AST | 0.51 | P < 0.05 |
| Ly6/neurotoxin-like protein 1 | LYNX1 | Aldolase | −0.52 | P < 0.05 |
AST: aspartate aminotransferase; CMAS: childhood myositis assessment score; DAS: disease activity score; MD: physician; MDAAT: myositis disease activity assessment tool; MDI: myositis damage index.
Correlations of a subset of significantly altered proteins with clinical measures of activity and disease in JDM patients
| Protein name . | Gene . | Clinical measure . | r . | P-value . |
|---|---|---|---|---|
| Cathepsin D | CTSD | MDI muscle damage | 0.57 | P < 0.05 |
| CMAS | −0.54 | P < 0.05 | ||
| MDAAT pulmonary | −0.54 | P < 0.05 | ||
| Collagen alpha-1(II) chain | COL2A1 | MD global disease damage | 0.48 | P < 0.05 |
| MDI total severity | 0.64 | P < 0.05 | ||
| CMAS | −0.60 | P < 0.05 | ||
| DAS muscle | 0.53 | P < 0.05 | ||
| Collagen alpha-1(I) chain | COL1A1 | AST | 0.46 | P < 0.05 |
| DAS muscle | 0.55 | P < 0.05 | ||
| MDAAT cardiovascular | −0.70 | P < 0.01 | ||
| Collagen alpha-1(XII) chain | COL12A1 | AST | 0.51 | P < 0.05 |
| Ly6/neurotoxin-like protein 1 | LYNX1 | Aldolase | −0.52 | P < 0.05 |
| Protein name . | Gene . | Clinical measure . | r . | P-value . |
|---|---|---|---|---|
| Cathepsin D | CTSD | MDI muscle damage | 0.57 | P < 0.05 |
| CMAS | −0.54 | P < 0.05 | ||
| MDAAT pulmonary | −0.54 | P < 0.05 | ||
| Collagen alpha-1(II) chain | COL2A1 | MD global disease damage | 0.48 | P < 0.05 |
| MDI total severity | 0.64 | P < 0.05 | ||
| CMAS | −0.60 | P < 0.05 | ||
| DAS muscle | 0.53 | P < 0.05 | ||
| Collagen alpha-1(I) chain | COL1A1 | AST | 0.46 | P < 0.05 |
| DAS muscle | 0.55 | P < 0.05 | ||
| MDAAT cardiovascular | −0.70 | P < 0.01 | ||
| Collagen alpha-1(XII) chain | COL12A1 | AST | 0.51 | P < 0.05 |
| Ly6/neurotoxin-like protein 1 | LYNX1 | Aldolase | −0.52 | P < 0.05 |
AST: aspartate aminotransferase; CMAS: childhood myositis assessment score; DAS: disease activity score; MD: physician; MDAAT: myositis disease activity assessment tool; MDI: myositis damage index.
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