| General characteristics . | Vietnam TBM Discovery Cohort (n = 210) . | Vietnam TBM Validation Cohort (n = 87) . | Indonesia TBM Validation Cohort (n = 468) . |
|---|---|---|---|
| Age | 43 (28–57) | 41 (25–57)a | 28 (22–37)b |
| Male sex | 131 (62.1%) | 37 (46.8%)a | 230 (55%) |
| Weight, kg | 49 (45–55) | 45 (40–49) | N/Ac |
| Disease characteristics | |||
| Duration of illness prior to presentation, d | 14 (10–30) | 17 (12–30)a | N/Ac |
| CSF WBC count, leukocytes/mm3 | 81 (28–231)d | 209 (82–375) | 155 (53–336) |
| Glasgow coma score | 15 (13–15) | 14 (13–15) | 13 (12–15)b |
| HIV seropositive | 0 (0%) | 0 (0%) | 50 (10.7%) |
| Diagnostic categorye | |||
| Definite TBM | 77 (36.5%) | 51 (58.6%) | 272 (65.1%) |
| Probable TBM | 66 (31.3%) | 27 (31.0%) | 146 (34.9% |
| Possible TBM | 68 (32.2%) | 9 (10.3%) | … |
| General characteristics . | Vietnam TBM Discovery Cohort (n = 210) . | Vietnam TBM Validation Cohort (n = 87) . | Indonesia TBM Validation Cohort (n = 468) . |
|---|---|---|---|
| Age | 43 (28–57) | 41 (25–57)a | 28 (22–37)b |
| Male sex | 131 (62.1%) | 37 (46.8%)a | 230 (55%) |
| Weight, kg | 49 (45–55) | 45 (40–49) | N/Ac |
| Disease characteristics | |||
| Duration of illness prior to presentation, d | 14 (10–30) | 17 (12–30)a | N/Ac |
| CSF WBC count, leukocytes/mm3 | 81 (28–231)d | 209 (82–375) | 155 (53–336) |
| Glasgow coma score | 15 (13–15) | 14 (13–15) | 13 (12–15)b |
| HIV seropositive | 0 (0%) | 0 (0%) | 50 (10.7%) |
| Diagnostic categorye | |||
| Definite TBM | 77 (36.5%) | 51 (58.6%) | 272 (65.1%) |
| Probable TBM | 66 (31.3%) | 27 (31.0%) | 146 (34.9% |
| Possible TBM | 68 (32.2%) | 9 (10.3%) | … |
Results are presented as median (interquartile range) for continuous variables or No. (%) for categorical variables.
Abbreviations: CSF, cerebral spinal fluid; HIV, human immunodeficiency virus; TBM, tuberculosis meningitis; WBC, white blood cell count.
n = 79 due to missingness.
n = 412 due to missingness.
Data not available.
n = 204 due to missingness.
Participant diagnostic category at study end. Diagnostic categories were defined either according to consensus criteria or study-specific criteria as described in the Supplementary Methods. Possible TBM was not defined for the Indonesia TBM validation cohort.
| General characteristics . | Vietnam TBM Discovery Cohort (n = 210) . | Vietnam TBM Validation Cohort (n = 87) . | Indonesia TBM Validation Cohort (n = 468) . |
|---|---|---|---|
| Age | 43 (28–57) | 41 (25–57)a | 28 (22–37)b |
| Male sex | 131 (62.1%) | 37 (46.8%)a | 230 (55%) |
| Weight, kg | 49 (45–55) | 45 (40–49) | N/Ac |
| Disease characteristics | |||
| Duration of illness prior to presentation, d | 14 (10–30) | 17 (12–30)a | N/Ac |
| CSF WBC count, leukocytes/mm3 | 81 (28–231)d | 209 (82–375) | 155 (53–336) |
| Glasgow coma score | 15 (13–15) | 14 (13–15) | 13 (12–15)b |
| HIV seropositive | 0 (0%) | 0 (0%) | 50 (10.7%) |
| Diagnostic categorye | |||
| Definite TBM | 77 (36.5%) | 51 (58.6%) | 272 (65.1%) |
| Probable TBM | 66 (31.3%) | 27 (31.0%) | 146 (34.9% |
| Possible TBM | 68 (32.2%) | 9 (10.3%) | … |
| General characteristics . | Vietnam TBM Discovery Cohort (n = 210) . | Vietnam TBM Validation Cohort (n = 87) . | Indonesia TBM Validation Cohort (n = 468) . |
|---|---|---|---|
| Age | 43 (28–57) | 41 (25–57)a | 28 (22–37)b |
| Male sex | 131 (62.1%) | 37 (46.8%)a | 230 (55%) |
| Weight, kg | 49 (45–55) | 45 (40–49) | N/Ac |
| Disease characteristics | |||
| Duration of illness prior to presentation, d | 14 (10–30) | 17 (12–30)a | N/Ac |
| CSF WBC count, leukocytes/mm3 | 81 (28–231)d | 209 (82–375) | 155 (53–336) |
| Glasgow coma score | 15 (13–15) | 14 (13–15) | 13 (12–15)b |
| HIV seropositive | 0 (0%) | 0 (0%) | 50 (10.7%) |
| Diagnostic categorye | |||
| Definite TBM | 77 (36.5%) | 51 (58.6%) | 272 (65.1%) |
| Probable TBM | 66 (31.3%) | 27 (31.0%) | 146 (34.9% |
| Possible TBM | 68 (32.2%) | 9 (10.3%) | … |
Results are presented as median (interquartile range) for continuous variables or No. (%) for categorical variables.
Abbreviations: CSF, cerebral spinal fluid; HIV, human immunodeficiency virus; TBM, tuberculosis meningitis; WBC, white blood cell count.
n = 79 due to missingness.
n = 412 due to missingness.
Data not available.
n = 204 due to missingness.
Participant diagnostic category at study end. Diagnostic categories were defined either according to consensus criteria or study-specific criteria as described in the Supplementary Methods. Possible TBM was not defined for the Indonesia TBM validation cohort.
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