Association of MUC5AC SNP rs28737416 With Diagnosis of Tuberculous Meningitis and Pulmonary Tuberculosis
| Genotype . | Controlsa . | Cases . | OR (95% CI) . | P Value . |
|---|---|---|---|---|
| Tuberculous meningitis | ||||
| (n = 1139) | (n = 407) | |||
| C/C | 582 (51.3) | 182 (45.4) | 1.24 (1.03–1.49) | .021 |
| T/C | 464 (40.9) | 169 (42.1) | ||
| T/T | 89 (7.8) | 50 (12.5) | ||
| Pulmonary tuberculosis | ||||
| (n = 1268) | (n = 1598) | |||
| C/C | 655 (51.6) | 662 (48.0) | 1.11 (.98–1.25) | .100 |
| T/C | 510 (40.2) | 588 (42.6) | ||
| T/T | 100 (7.9) | 129 (9.3) | ||
| Genotype . | Controlsa . | Cases . | OR (95% CI) . | P Value . |
|---|---|---|---|---|
| Tuberculous meningitis | ||||
| (n = 1139) | (n = 407) | |||
| C/C | 582 (51.3) | 182 (45.4) | 1.24 (1.03–1.49) | .021 |
| T/C | 464 (40.9) | 169 (42.1) | ||
| T/T | 89 (7.8) | 50 (12.5) | ||
| Pulmonary tuberculosis | ||||
| (n = 1268) | (n = 1598) | |||
| C/C | 655 (51.6) | 662 (48.0) | 1.11 (.98–1.25) | .100 |
| T/C | 510 (40.2) | 588 (42.6) | ||
| T/T | 100 (7.9) | 129 (9.3) | ||
Data are No. (%).
The odds of being diagnosed with either tuberculous meningitis or pulmonary tuberculosis (analyzed separately) in the presence of the MUC5AC SNP rs28737416 T/T genotype was compared between cases and controls using logistic regression based on an additive genetic model. The total number of individuals with major homozygous (C/C), heterozygous (T/C), and minor homozygous (T/T) genotypes are shown.
Abbreviations: CI, confidence interval; OR, odds ratio; PACG, primary angle closure glaucoma; SNP, single nucleotide polymorphism.
Controls were generated from the same cohort of participants with PACG. The number of controls differs between groups because each dataset (ie, the tuberculous meningitis-PACG dataset and the pulmonary tuberculosis-PACG dataset) were combined prior to SNP quality control. Please see methods for additional details.
Association of MUC5AC SNP rs28737416 With Diagnosis of Tuberculous Meningitis and Pulmonary Tuberculosis
| Genotype . | Controlsa . | Cases . | OR (95% CI) . | P Value . |
|---|---|---|---|---|
| Tuberculous meningitis | ||||
| (n = 1139) | (n = 407) | |||
| C/C | 582 (51.3) | 182 (45.4) | 1.24 (1.03–1.49) | .021 |
| T/C | 464 (40.9) | 169 (42.1) | ||
| T/T | 89 (7.8) | 50 (12.5) | ||
| Pulmonary tuberculosis | ||||
| (n = 1268) | (n = 1598) | |||
| C/C | 655 (51.6) | 662 (48.0) | 1.11 (.98–1.25) | .100 |
| T/C | 510 (40.2) | 588 (42.6) | ||
| T/T | 100 (7.9) | 129 (9.3) | ||
| Genotype . | Controlsa . | Cases . | OR (95% CI) . | P Value . |
|---|---|---|---|---|
| Tuberculous meningitis | ||||
| (n = 1139) | (n = 407) | |||
| C/C | 582 (51.3) | 182 (45.4) | 1.24 (1.03–1.49) | .021 |
| T/C | 464 (40.9) | 169 (42.1) | ||
| T/T | 89 (7.8) | 50 (12.5) | ||
| Pulmonary tuberculosis | ||||
| (n = 1268) | (n = 1598) | |||
| C/C | 655 (51.6) | 662 (48.0) | 1.11 (.98–1.25) | .100 |
| T/C | 510 (40.2) | 588 (42.6) | ||
| T/T | 100 (7.9) | 129 (9.3) | ||
Data are No. (%).
The odds of being diagnosed with either tuberculous meningitis or pulmonary tuberculosis (analyzed separately) in the presence of the MUC5AC SNP rs28737416 T/T genotype was compared between cases and controls using logistic regression based on an additive genetic model. The total number of individuals with major homozygous (C/C), heterozygous (T/C), and minor homozygous (T/T) genotypes are shown.
Abbreviations: CI, confidence interval; OR, odds ratio; PACG, primary angle closure glaucoma; SNP, single nucleotide polymorphism.
Controls were generated from the same cohort of participants with PACG. The number of controls differs between groups because each dataset (ie, the tuberculous meningitis-PACG dataset and the pulmonary tuberculosis-PACG dataset) were combined prior to SNP quality control. Please see methods for additional details.
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