Table 4

MRI findings in sporadic Creutzfeldt–Jakob disease MV2K

Overall MV2KaDefinite MV2KDefinite MV2K + 2C
n772418
Positive examination (typical)71 (92.2)22 (91.7)17 (94.4)
Topographic distribution of hyperintensitiesb
Striatum58 (81.6)21 (95.5)14 (82.4)
Neocorticesc35 (49.3)4 (18.2)11 (64.7)
 Temporal33 (46.5)5 (22.7)10 (58.8)
 Parietal37 (52.1)4 (18.2)11 (64.7)
 Occipital35 (49.3)5 (22.7)11 (64.7)
Thalamus24 (33.8)9 (40.9)5 (29.4)
 Limbic11 (15.5)6 (27.3)0 (0.0)
 Hippocampus5 (7.0)4 (18.2)
 Insula5 (7.0)2 (9.1)
 Cingulate gyrus3 (4.2)1 (4.5)
Timing (months)7.0 ± 3.37.2 ± 3.47.4 ± 3.9
Overall MV2KaDefinite MV2KDefinite MV2K + 2C
n772418
Positive examination (typical)71 (92.2)22 (91.7)17 (94.4)
Topographic distribution of hyperintensitiesb
Striatum58 (81.6)21 (95.5)14 (82.4)
Neocorticesc35 (49.3)4 (18.2)11 (64.7)
 Temporal33 (46.5)5 (22.7)10 (58.8)
 Parietal37 (52.1)4 (18.2)11 (64.7)
 Occipital35 (49.3)5 (22.7)11 (64.7)
Thalamus24 (33.8)9 (40.9)5 (29.4)
 Limbic11 (15.5)6 (27.3)0 (0.0)
 Hippocampus5 (7.0)4 (18.2)
 Insula5 (7.0)2 (9.1)
 Cingulate gyrus3 (4.2)1 (4.5)
Timing (months)7.0 ± 3.37.2 ± 3.47.4 ± 3.9

Only the examinations including DWI and/or FLAIR sequences were included. Positive examination was defined according to revised diagnostic sporadic Creutzfeldt–Jakob disease criteria.25

Includes both definite and probable cases.

Frequencies were calculated only for typical cases.

Isolated hyperintensities were found in the temporal (n = 1), parietal (n = 4) and occipital cortex (n = 3). Additionally, frontal neocortex showed hyperintensities in 31 cases.

Table 4

MRI findings in sporadic Creutzfeldt–Jakob disease MV2K

Overall MV2KaDefinite MV2KDefinite MV2K + 2C
n772418
Positive examination (typical)71 (92.2)22 (91.7)17 (94.4)
Topographic distribution of hyperintensitiesb
Striatum58 (81.6)21 (95.5)14 (82.4)
Neocorticesc35 (49.3)4 (18.2)11 (64.7)
 Temporal33 (46.5)5 (22.7)10 (58.8)
 Parietal37 (52.1)4 (18.2)11 (64.7)
 Occipital35 (49.3)5 (22.7)11 (64.7)
Thalamus24 (33.8)9 (40.9)5 (29.4)
 Limbic11 (15.5)6 (27.3)0 (0.0)
 Hippocampus5 (7.0)4 (18.2)
 Insula5 (7.0)2 (9.1)
 Cingulate gyrus3 (4.2)1 (4.5)
Timing (months)7.0 ± 3.37.2 ± 3.47.4 ± 3.9
Overall MV2KaDefinite MV2KDefinite MV2K + 2C
n772418
Positive examination (typical)71 (92.2)22 (91.7)17 (94.4)
Topographic distribution of hyperintensitiesb
Striatum58 (81.6)21 (95.5)14 (82.4)
Neocorticesc35 (49.3)4 (18.2)11 (64.7)
 Temporal33 (46.5)5 (22.7)10 (58.8)
 Parietal37 (52.1)4 (18.2)11 (64.7)
 Occipital35 (49.3)5 (22.7)11 (64.7)
Thalamus24 (33.8)9 (40.9)5 (29.4)
 Limbic11 (15.5)6 (27.3)0 (0.0)
 Hippocampus5 (7.0)4 (18.2)
 Insula5 (7.0)2 (9.1)
 Cingulate gyrus3 (4.2)1 (4.5)
Timing (months)7.0 ± 3.37.2 ± 3.47.4 ± 3.9

Only the examinations including DWI and/or FLAIR sequences were included. Positive examination was defined according to revised diagnostic sporadic Creutzfeldt–Jakob disease criteria.25

Includes both definite and probable cases.

Frequencies were calculated only for typical cases.

Isolated hyperintensities were found in the temporal (n = 1), parietal (n = 4) and occipital cortex (n = 3). Additionally, frontal neocortex showed hyperintensities in 31 cases.

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