| N . | Quintile 1 . | Quintile 2 . | Quintile 3 . | Quintile 4 . | Quintile 5 . | P valuea . |
|---|---|---|---|---|---|---|
| 209 . | 209 . | 209 . | 209 . | 209 . | ||
| Weight change slope over first 2 years (kg/year) | −3.4 (−4.9 to −2.5) | −0.9 (−1.4 to −0.3) | 0.9 (0.6 to 1.3) | 2.8 (2.2 to 3.2) | 6.4 (5.0 to 8.8) | |
| Total weight change over entire study | −4.5 (−8.2 to −1.8) | −0.5 (−2.3 to 2.3) | 0.9 (−1.8 to 3.6) | 3.6 (0.9 to 7.3) | 9.1 (3.2 to 14.5) | |
| Total study follow-up time | 3.2 (2.1 to 4.6) | 4.0 (3.0 to 5.0) | 4.0 (3.1 to 5.0) | 3.7 (3.0 to 5.0) | 4.1 (2.7 to 5.0) | 0.002 |
| Age (years) | 55.4 (10.5) | 55.4 (10.8) | 56.7 (10.2) | 53.6 (10.8) | 51.7 (10.6) | <0.001 |
| Female (%) | 41.6 | 35.9 | 39.2 | 40.2 | 37.3 | 0.8 |
| <High school education (%) | 40.2 | 48.8 | 40.2 | 36.8 | 38.8 | 0.1 |
| Current smoker (%) | 31.1 | 31.6 | 30.6 | 23.4 | 31.1 | 0.3 |
| History of heart disease (%) | 53.1 | 49.3 | 54.1 | 46.9 | 54.5 | 0.4 |
| Height (cm) | 170.4 (10.2) | 171.5 (9.9) | 170.2 (9.5) | 170.5 (10.0) | 172.5 (10.7) | 0.1 |
| Weight (kg) | 90.9 (22.4) | 87.6 (19.0) | 85.1 (18.5) | 88.7 (18.9) | 94.7 (22.7) | <0.001 |
| BMI (kg/m2) | 31.3 (7.1) | 29.8 (6.3) | 29.4 (6.1) | 30.6 (6.4) | 31.7 (6.6) | 0.001 |
| BSA (m2) | 2.01 (0.26) | 1.99 (0.23) | 1.96 (0.22) | 2.00 (0.23) | 2.08 (0.27) | <0.001 |
| SBP (mmHg) | 152.6 (24.5) | 150.7 (22.8) | 148.4 (23.4) | 148.5 (23.5) | 149.8 (23.1) | 0.3 |
| DBP (mmHg) | 96.8 (14.5) | 94.6 (13.9) | 93.3 (13.6) | 95.1 (13.8) | 97.3 (14.6) | 0.02 |
| mGFR (mL/min/1.73 m2) | 44.2 (14.3) | 46.8 (14.2) | 47.8 (13.1) | 47.9 (13.4) | 46.2 (12.6) | 0.04 |
| Protein/creatinine ratio >0.22 (%) | 40.7 | 33.0 | 20.6 | 27.3 | 37.8 | <0.001 |
| Randomized to low BP goal (%) | 48.3 | 47.8 | 55.0 | 50.2 | 48.8 | 0.6 |
| Randomized drug (%) | ||||||
| Ramipril | 43.5 | 40.7 | 42.6 | 36.4 | 34.5 | 0.7 |
| Metoprolol | 34.5 | 38.8 | 39.7 | 43.5 | 47.4 | |
| Amlodipine | 22.0 | 20.6 | 17.7 | 20.1 | 18.2 | |
| Baseline diuretic use (%) | 66.5 | 61.7 | 62.9 | 64.9 | 64.7 | 0.9 |
| N . | Quintile 1 . | Quintile 2 . | Quintile 3 . | Quintile 4 . | Quintile 5 . | P valuea . |
|---|---|---|---|---|---|---|
| 209 . | 209 . | 209 . | 209 . | 209 . | ||
| Weight change slope over first 2 years (kg/year) | −3.4 (−4.9 to −2.5) | −0.9 (−1.4 to −0.3) | 0.9 (0.6 to 1.3) | 2.8 (2.2 to 3.2) | 6.4 (5.0 to 8.8) | |
| Total weight change over entire study | −4.5 (−8.2 to −1.8) | −0.5 (−2.3 to 2.3) | 0.9 (−1.8 to 3.6) | 3.6 (0.9 to 7.3) | 9.1 (3.2 to 14.5) | |
| Total study follow-up time | 3.2 (2.1 to 4.6) | 4.0 (3.0 to 5.0) | 4.0 (3.1 to 5.0) | 3.7 (3.0 to 5.0) | 4.1 (2.7 to 5.0) | 0.002 |
| Age (years) | 55.4 (10.5) | 55.4 (10.8) | 56.7 (10.2) | 53.6 (10.8) | 51.7 (10.6) | <0.001 |
| Female (%) | 41.6 | 35.9 | 39.2 | 40.2 | 37.3 | 0.8 |
| <High school education (%) | 40.2 | 48.8 | 40.2 | 36.8 | 38.8 | 0.1 |
| Current smoker (%) | 31.1 | 31.6 | 30.6 | 23.4 | 31.1 | 0.3 |
| History of heart disease (%) | 53.1 | 49.3 | 54.1 | 46.9 | 54.5 | 0.4 |
| Height (cm) | 170.4 (10.2) | 171.5 (9.9) | 170.2 (9.5) | 170.5 (10.0) | 172.5 (10.7) | 0.1 |
| Weight (kg) | 90.9 (22.4) | 87.6 (19.0) | 85.1 (18.5) | 88.7 (18.9) | 94.7 (22.7) | <0.001 |
| BMI (kg/m2) | 31.3 (7.1) | 29.8 (6.3) | 29.4 (6.1) | 30.6 (6.4) | 31.7 (6.6) | 0.001 |
| BSA (m2) | 2.01 (0.26) | 1.99 (0.23) | 1.96 (0.22) | 2.00 (0.23) | 2.08 (0.27) | <0.001 |
| SBP (mmHg) | 152.6 (24.5) | 150.7 (22.8) | 148.4 (23.4) | 148.5 (23.5) | 149.8 (23.1) | 0.3 |
| DBP (mmHg) | 96.8 (14.5) | 94.6 (13.9) | 93.3 (13.6) | 95.1 (13.8) | 97.3 (14.6) | 0.02 |
| mGFR (mL/min/1.73 m2) | 44.2 (14.3) | 46.8 (14.2) | 47.8 (13.1) | 47.9 (13.4) | 46.2 (12.6) | 0.04 |
| Protein/creatinine ratio >0.22 (%) | 40.7 | 33.0 | 20.6 | 27.3 | 37.8 | <0.001 |
| Randomized to low BP goal (%) | 48.3 | 47.8 | 55.0 | 50.2 | 48.8 | 0.6 |
| Randomized drug (%) | ||||||
| Ramipril | 43.5 | 40.7 | 42.6 | 36.4 | 34.5 | 0.7 |
| Metoprolol | 34.5 | 38.8 | 39.7 | 43.5 | 47.4 | |
| Amlodipine | 22.0 | 20.6 | 17.7 | 20.1 | 18.2 | |
| Baseline diuretic use (%) | 66.5 | 61.7 | 62.9 | 64.9 | 64.7 | 0.9 |
Annual slope of weight change was determined for each individual using ordinary least squares regression with first 2 years of weight data to minimize the effect of survival on category of weight change. Weight change slope, total weight change and total study follow-up time are reported as median (IQR). Otherwise, results are presented as mean (SD) or percentages.
aMeans and proportions of baseline characteristics compared using ANOVA.
| N . | Quintile 1 . | Quintile 2 . | Quintile 3 . | Quintile 4 . | Quintile 5 . | P valuea . |
|---|---|---|---|---|---|---|
| 209 . | 209 . | 209 . | 209 . | 209 . | ||
| Weight change slope over first 2 years (kg/year) | −3.4 (−4.9 to −2.5) | −0.9 (−1.4 to −0.3) | 0.9 (0.6 to 1.3) | 2.8 (2.2 to 3.2) | 6.4 (5.0 to 8.8) | |
| Total weight change over entire study | −4.5 (−8.2 to −1.8) | −0.5 (−2.3 to 2.3) | 0.9 (−1.8 to 3.6) | 3.6 (0.9 to 7.3) | 9.1 (3.2 to 14.5) | |
| Total study follow-up time | 3.2 (2.1 to 4.6) | 4.0 (3.0 to 5.0) | 4.0 (3.1 to 5.0) | 3.7 (3.0 to 5.0) | 4.1 (2.7 to 5.0) | 0.002 |
| Age (years) | 55.4 (10.5) | 55.4 (10.8) | 56.7 (10.2) | 53.6 (10.8) | 51.7 (10.6) | <0.001 |
| Female (%) | 41.6 | 35.9 | 39.2 | 40.2 | 37.3 | 0.8 |
| <High school education (%) | 40.2 | 48.8 | 40.2 | 36.8 | 38.8 | 0.1 |
| Current smoker (%) | 31.1 | 31.6 | 30.6 | 23.4 | 31.1 | 0.3 |
| History of heart disease (%) | 53.1 | 49.3 | 54.1 | 46.9 | 54.5 | 0.4 |
| Height (cm) | 170.4 (10.2) | 171.5 (9.9) | 170.2 (9.5) | 170.5 (10.0) | 172.5 (10.7) | 0.1 |
| Weight (kg) | 90.9 (22.4) | 87.6 (19.0) | 85.1 (18.5) | 88.7 (18.9) | 94.7 (22.7) | <0.001 |
| BMI (kg/m2) | 31.3 (7.1) | 29.8 (6.3) | 29.4 (6.1) | 30.6 (6.4) | 31.7 (6.6) | 0.001 |
| BSA (m2) | 2.01 (0.26) | 1.99 (0.23) | 1.96 (0.22) | 2.00 (0.23) | 2.08 (0.27) | <0.001 |
| SBP (mmHg) | 152.6 (24.5) | 150.7 (22.8) | 148.4 (23.4) | 148.5 (23.5) | 149.8 (23.1) | 0.3 |
| DBP (mmHg) | 96.8 (14.5) | 94.6 (13.9) | 93.3 (13.6) | 95.1 (13.8) | 97.3 (14.6) | 0.02 |
| mGFR (mL/min/1.73 m2) | 44.2 (14.3) | 46.8 (14.2) | 47.8 (13.1) | 47.9 (13.4) | 46.2 (12.6) | 0.04 |
| Protein/creatinine ratio >0.22 (%) | 40.7 | 33.0 | 20.6 | 27.3 | 37.8 | <0.001 |
| Randomized to low BP goal (%) | 48.3 | 47.8 | 55.0 | 50.2 | 48.8 | 0.6 |
| Randomized drug (%) | ||||||
| Ramipril | 43.5 | 40.7 | 42.6 | 36.4 | 34.5 | 0.7 |
| Metoprolol | 34.5 | 38.8 | 39.7 | 43.5 | 47.4 | |
| Amlodipine | 22.0 | 20.6 | 17.7 | 20.1 | 18.2 | |
| Baseline diuretic use (%) | 66.5 | 61.7 | 62.9 | 64.9 | 64.7 | 0.9 |
| N . | Quintile 1 . | Quintile 2 . | Quintile 3 . | Quintile 4 . | Quintile 5 . | P valuea . |
|---|---|---|---|---|---|---|
| 209 . | 209 . | 209 . | 209 . | 209 . | ||
| Weight change slope over first 2 years (kg/year) | −3.4 (−4.9 to −2.5) | −0.9 (−1.4 to −0.3) | 0.9 (0.6 to 1.3) | 2.8 (2.2 to 3.2) | 6.4 (5.0 to 8.8) | |
| Total weight change over entire study | −4.5 (−8.2 to −1.8) | −0.5 (−2.3 to 2.3) | 0.9 (−1.8 to 3.6) | 3.6 (0.9 to 7.3) | 9.1 (3.2 to 14.5) | |
| Total study follow-up time | 3.2 (2.1 to 4.6) | 4.0 (3.0 to 5.0) | 4.0 (3.1 to 5.0) | 3.7 (3.0 to 5.0) | 4.1 (2.7 to 5.0) | 0.002 |
| Age (years) | 55.4 (10.5) | 55.4 (10.8) | 56.7 (10.2) | 53.6 (10.8) | 51.7 (10.6) | <0.001 |
| Female (%) | 41.6 | 35.9 | 39.2 | 40.2 | 37.3 | 0.8 |
| <High school education (%) | 40.2 | 48.8 | 40.2 | 36.8 | 38.8 | 0.1 |
| Current smoker (%) | 31.1 | 31.6 | 30.6 | 23.4 | 31.1 | 0.3 |
| History of heart disease (%) | 53.1 | 49.3 | 54.1 | 46.9 | 54.5 | 0.4 |
| Height (cm) | 170.4 (10.2) | 171.5 (9.9) | 170.2 (9.5) | 170.5 (10.0) | 172.5 (10.7) | 0.1 |
| Weight (kg) | 90.9 (22.4) | 87.6 (19.0) | 85.1 (18.5) | 88.7 (18.9) | 94.7 (22.7) | <0.001 |
| BMI (kg/m2) | 31.3 (7.1) | 29.8 (6.3) | 29.4 (6.1) | 30.6 (6.4) | 31.7 (6.6) | 0.001 |
| BSA (m2) | 2.01 (0.26) | 1.99 (0.23) | 1.96 (0.22) | 2.00 (0.23) | 2.08 (0.27) | <0.001 |
| SBP (mmHg) | 152.6 (24.5) | 150.7 (22.8) | 148.4 (23.4) | 148.5 (23.5) | 149.8 (23.1) | 0.3 |
| DBP (mmHg) | 96.8 (14.5) | 94.6 (13.9) | 93.3 (13.6) | 95.1 (13.8) | 97.3 (14.6) | 0.02 |
| mGFR (mL/min/1.73 m2) | 44.2 (14.3) | 46.8 (14.2) | 47.8 (13.1) | 47.9 (13.4) | 46.2 (12.6) | 0.04 |
| Protein/creatinine ratio >0.22 (%) | 40.7 | 33.0 | 20.6 | 27.3 | 37.8 | <0.001 |
| Randomized to low BP goal (%) | 48.3 | 47.8 | 55.0 | 50.2 | 48.8 | 0.6 |
| Randomized drug (%) | ||||||
| Ramipril | 43.5 | 40.7 | 42.6 | 36.4 | 34.5 | 0.7 |
| Metoprolol | 34.5 | 38.8 | 39.7 | 43.5 | 47.4 | |
| Amlodipine | 22.0 | 20.6 | 17.7 | 20.1 | 18.2 | |
| Baseline diuretic use (%) | 66.5 | 61.7 | 62.9 | 64.9 | 64.7 | 0.9 |
Annual slope of weight change was determined for each individual using ordinary least squares regression with first 2 years of weight data to minimize the effect of survival on category of weight change. Weight change slope, total weight change and total study follow-up time are reported as median (IQR). Otherwise, results are presented as mean (SD) or percentages.
aMeans and proportions of baseline characteristics compared using ANOVA.
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