Table 1. Open in new tab Estimated...

Predicted Log-Normal Distributions	Plasmodium falciparum	Plasmodium vivax^a
P_PF = 0.1214 for all parasite densities (30–30 000 000 parasites/mL)
Mean	2.86	1.97–3.31	2.75–2.97	3.34	3.31–3.38	3.33–3.35	3.25	3.16–3.33	3.23–3.27
SD	2.16	1.90–2.66	2.09–2.22	1.60	1.57–1.62	1.60–1.60	1.64	1.58–1.71	1.63–1.66
Percentage below LLOQ^b	25.6	16.3–42.2	23.3–27.8	11.8	11.0–12.6	11.7–12.0	13.6	11.7–15.7	13.2–14.0
Percentage above ULOQ^c	1.6	1.1–2.1	1.5–1.7	0.48	0.45–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52
P_PF = 0.1534 for parasite density of 30–999 parasites/mL; 0.1124 for parasite density 1000–30 000 000 parasites/mL
Mean	2.64	1.92–3.27	2.49–2.79	3.35	3.31–3.39	3.35–3.36	3.26	3.15–3.36	3.24–3.28
SD	2.26	1.95–2.65	2.17–2.33	1.59	1.57–1.61	1.59–1.60	1.63	1.56–1.72	1.62–1.65
Percentage below LLOQ^b	29.8	17.9–42.9	26.8–32.7	11.5	10.9–12.4	11.4–11.7	13.3	11.0–16.1	12.9–13.8
Percentage above ULOQ^c	1.6	1.1–2.2	1.5–1.7	0.48	0.46–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52

Predicted Log-Normal Distributions

Plasmodium falciparum

Plasmodium vivax^a

Scenario A

Scenario B

Mean

Range

IQR

Mean

Range

IQR

Mean

Range

IQR

P_PF = 0.1214 for all parasite densities (30–30 000 000 parasites/mL)

Mean

2.86

1.97–3.31

2.75–2.97

3.34

3.31–3.38

3.33–3.35

3.25

3.16–3.33

3.23–3.27

2.16

1.90–2.66

2.09–2.22

1.60

1.57–1.62

1.60–1.60

1.64

1.58–1.71

1.63–1.66

Percentage below LLOQ^b

25.6

16.3–42.2

23.3–27.8

11.8

11.0–12.6

11.7–12.0

13.6

11.7–15.7

13.2–14.0

Percentage above ULOQ^c

1.6

1.1–2.1

1.5–1.7

0.48

0.45–0.51

0.48–0.49

0.50

0.42–0.59

0.48–0.52

P_PF = 0.1534 for parasite density of 30–999 parasites/mL; 0.1124 for parasite density 1000–30 000 000 parasites/mL

Mean

2.64

1.92–3.27

2.49–2.79

3.35

3.31–3.39

3.35–3.36

3.26

3.15–3.36

3.24–3.28

2.26

1.95–2.65

2.17–2.33

1.59

1.57–1.61

1.59–1.60

1.63

1.56–1.72

1.62–1.65

Percentage below LLOQ^b

29.8

17.9–42.9

26.8–32.7

11.5

10.9–12.4

11.4–11.7

13.3

11.0–16.1

12.9–13.8

Percentage above ULOQ^c

1.6

1.1–2.2

1.5–1.7

0.48

0.46–0.51

0.48–0.49

0.50

0.42–0.59

0.48–0.52

Predicted Log-Normal Distributions	Plasmodium falciparum	Plasmodium vivax^a
P_PF = 0.1214 for all parasite densities (30–30 000 000 parasites/mL)
Mean	2.86	1.97–3.31	2.75–2.97	3.34	3.31–3.38	3.33–3.35	3.25	3.16–3.33	3.23–3.27
SD	2.16	1.90–2.66	2.09–2.22	1.60	1.57–1.62	1.60–1.60	1.64	1.58–1.71	1.63–1.66
Percentage below LLOQ^b	25.6	16.3–42.2	23.3–27.8	11.8	11.0–12.6	11.7–12.0	13.6	11.7–15.7	13.2–14.0
Percentage above ULOQ^c	1.6	1.1–2.1	1.5–1.7	0.48	0.45–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52
P_PF = 0.1534 for parasite density of 30–999 parasites/mL; 0.1124 for parasite density 1000–30 000 000 parasites/mL
Mean	2.64	1.92–3.27	2.49–2.79	3.35	3.31–3.39	3.35–3.36	3.26	3.15–3.36	3.24–3.28
SD	2.26	1.95–2.65	2.17–2.33	1.59	1.57–1.61	1.59–1.60	1.63	1.56–1.72	1.62–1.65
Percentage below LLOQ^b	29.8	17.9–42.9	26.8–32.7	11.5	10.9–12.4	11.4–11.7	13.3	11.0–16.1	12.9–13.8
Percentage above ULOQ^c	1.6	1.1–2.2	1.5–1.7	0.48	0.46–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52

Table 1.

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Estimated Parasite Density Distributions Derived From 1000 Imputed Data Sets

Predicted Log-Normal Distributions	Plasmodium falciparum			Plasmodium vivax^a
				Scenario A			Scenario B
	Mean	Range	IQR	Mean	Range	IQR	Mean	Range	IQR
P_PF = 0.1214 for all parasite densities (30–30 000 000 parasites/mL)
Mean	2.86	1.97–3.31	2.75–2.97	3.34	3.31–3.38	3.33–3.35	3.25	3.16–3.33	3.23–3.27
SD	2.16	1.90–2.66	2.09–2.22	1.60	1.57–1.62	1.60–1.60	1.64	1.58–1.71	1.63–1.66
Percentage below LLOQ^b	25.6	16.3–42.2	23.3–27.8	11.8	11.0–12.6	11.7–12.0	13.6	11.7–15.7	13.2–14.0
Percentage above ULOQ^c	1.6	1.1–2.1	1.5–1.7	0.48	0.45–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52
P_PF = 0.1534 for parasite density of 30–999 parasites/mL; 0.1124 for parasite density 1000–30 000 000 parasites/mL
Mean	2.64	1.92–3.27	2.49–2.79	3.35	3.31–3.39	3.35–3.36	3.26	3.15–3.36	3.24–3.28
SD	2.26	1.95–2.65	2.17–2.33	1.59	1.57–1.61	1.59–1.60	1.63	1.56–1.72	1.62–1.65
Percentage below LLOQ^b	29.8	17.9–42.9	26.8–32.7	11.5	10.9–12.4	11.4–11.7	13.3	11.0–16.1	12.9–13.8
Percentage above ULOQ^c	1.6	1.1–2.2	1.5–1.7	0.48	0.46–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52

Predicted Log-Normal Distributions	Plasmodium falciparum			Plasmodium vivax^a
				Scenario A			Scenario B
	Mean	Range	IQR	Mean	Range	IQR	Mean	Range	IQR
P_PF = 0.1214 for all parasite densities (30–30 000 000 parasites/mL)
Mean	2.86	1.97–3.31	2.75–2.97	3.34	3.31–3.38	3.33–3.35	3.25	3.16–3.33	3.23–3.27
SD	2.16	1.90–2.66	2.09–2.22	1.60	1.57–1.62	1.60–1.60	1.64	1.58–1.71	1.63–1.66
Percentage below LLOQ^b	25.6	16.3–42.2	23.3–27.8	11.8	11.0–12.6	11.7–12.0	13.6	11.7–15.7	13.2–14.0
Percentage above ULOQ^c	1.6	1.1–2.1	1.5–1.7	0.48	0.45–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52
P_PF = 0.1534 for parasite density of 30–999 parasites/mL; 0.1124 for parasite density 1000–30 000 000 parasites/mL
Mean	2.64	1.92–3.27	2.49–2.79	3.35	3.31–3.39	3.35–3.36	3.26	3.15–3.36	3.24–3.28
SD	2.26	1.95–2.65	2.17–2.33	1.59	1.57–1.61	1.59–1.60	1.63	1.56–1.72	1.62–1.65
Percentage below LLOQ^b	29.8	17.9–42.9	26.8–32.7	11.5	10.9–12.4	11.4–11.7	13.3	11.0–16.1	12.9–13.8
Percentage above ULOQ^c	1.6	1.1–2.2	1.5–1.7	0.48	0.46–0.51	0.48–0.49	0.50	0.42–0.59	0.48–0.52

Abbreviations: IQR, interquartile range; P_PF, probability of infection being due to P. falciparum; SD, standard deviation.

^a Scenario A describes asynchronous infections. Scenario B describes synchronous infections (SD, 4 hours).

^b The lower limit of quantification (LLOQ) was defined as <30 parasites/mL.

^c The upper limit of quantification (ULOQ) was defined as >30 000 000 parasites/mL.

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