Table 3
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Unadjusted and Adjusted Hazard Ratios for mRNA-1273 With BNT162b2 and Ad26.COV2.S (Primary Series) and With BNT162b2 (Booster Dose)

Primary SeriesBooster
mRNA-1273 vs BNT162b2mRNA-1273 vs Ad26.COV2.SmRNA-1273 vs BNT162b2
Outcome TypeUnadjusted HRAdjusted HRUnadjusted HRAdjusted HRUnadjusted HRAdjusted HR
Any medically attended COVID-19a0.76 (0.75–0.78)0.77 (0.75–0.78)0.50 (0.49–0.52)0.50 (0.49–0.52)0.81 (0.78–0.85)0.86 (0.82–0.90)
Outpatient COVID-19b0.76 (0.74–0.78)0.77 (0.75–0.78)0.50 (0.48–0.52)0.50 (0.48–0.52)0.83 (0.79–0.87)0.87 (0.83–0.92)
COVID-19 Hospitalizationc0.84 (0.79–0.90)0.81 (0.76–0.86)0.43 (0.39–0.47)0.43 (0.39–0.47)0.77 (0.63–0.94)0.81 (0.66–0.99)
Primary SeriesBooster
mRNA-1273 vs BNT162b2mRNA-1273 vs Ad26.COV2.SmRNA-1273 vs BNT162b2
Outcome TypeUnadjusted HRAdjusted HRUnadjusted HRAdjusted HRUnadjusted HRAdjusted HR
Any medically attended COVID-19a0.76 (0.75–0.78)0.77 (0.75–0.78)0.50 (0.49–0.52)0.50 (0.49–0.52)0.81 (0.78–0.85)0.86 (0.82–0.90)
Outpatient COVID-19b0.76 (0.74–0.78)0.77 (0.75–0.78)0.50 (0.48–0.52)0.50 (0.48–0.52)0.83 (0.79–0.87)0.87 (0.83–0.92)
COVID-19 Hospitalizationc0.84 (0.79–0.90)0.81 (0.76–0.86)0.43 (0.39–0.47)0.43 (0.39–0.47)0.77 (0.63–0.94)0.81 (0.66–0.99)

Details of the codes used to identify COVID-19-related medical encounters are provided in Supplementary Table 2.

Abbreviations: COVID-19, coronavirus disease 2019; EHR, electronic health record; HR, hazard ratio.

a

Defined as any medical encounter with a COVID-19 diagnosis or positive COVID-19 laboratory test.

b

Defined as a hospitalization where COVID-19 was listed in any diagnosis position.

c

Defined as an encounter recorded either in the EHR or on a claim that is not a hospitalization claim.

Table 3
Open in new tab

Unadjusted and Adjusted Hazard Ratios for mRNA-1273 With BNT162b2 and Ad26.COV2.S (Primary Series) and With BNT162b2 (Booster Dose)

Primary SeriesBooster
mRNA-1273 vs BNT162b2mRNA-1273 vs Ad26.COV2.SmRNA-1273 vs BNT162b2
Outcome TypeUnadjusted HRAdjusted HRUnadjusted HRAdjusted HRUnadjusted HRAdjusted HR
Any medically attended COVID-19a0.76 (0.75–0.78)0.77 (0.75–0.78)0.50 (0.49–0.52)0.50 (0.49–0.52)0.81 (0.78–0.85)0.86 (0.82–0.90)
Outpatient COVID-19b0.76 (0.74–0.78)0.77 (0.75–0.78)0.50 (0.48–0.52)0.50 (0.48–0.52)0.83 (0.79–0.87)0.87 (0.83–0.92)
COVID-19 Hospitalizationc0.84 (0.79–0.90)0.81 (0.76–0.86)0.43 (0.39–0.47)0.43 (0.39–0.47)0.77 (0.63–0.94)0.81 (0.66–0.99)
Primary SeriesBooster
mRNA-1273 vs BNT162b2mRNA-1273 vs Ad26.COV2.SmRNA-1273 vs BNT162b2
Outcome TypeUnadjusted HRAdjusted HRUnadjusted HRAdjusted HRUnadjusted HRAdjusted HR
Any medically attended COVID-19a0.76 (0.75–0.78)0.77 (0.75–0.78)0.50 (0.49–0.52)0.50 (0.49–0.52)0.81 (0.78–0.85)0.86 (0.82–0.90)
Outpatient COVID-19b0.76 (0.74–0.78)0.77 (0.75–0.78)0.50 (0.48–0.52)0.50 (0.48–0.52)0.83 (0.79–0.87)0.87 (0.83–0.92)
COVID-19 Hospitalizationc0.84 (0.79–0.90)0.81 (0.76–0.86)0.43 (0.39–0.47)0.43 (0.39–0.47)0.77 (0.63–0.94)0.81 (0.66–0.99)

Details of the codes used to identify COVID-19-related medical encounters are provided in Supplementary Table 2.

Abbreviations: COVID-19, coronavirus disease 2019; EHR, electronic health record; HR, hazard ratio.

a

Defined as any medical encounter with a COVID-19 diagnosis or positive COVID-19 laboratory test.

b

Defined as a hospitalization where COVID-19 was listed in any diagnosis position.

c

Defined as an encounter recorded either in the EHR or on a claim that is not a hospitalization claim.

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