Table 1 Open in new tab Baseline...

	All patients (n = 353)	Q1 nPTT [<244]	Q2 nPTT [244–410]	Q3 nPTT [410–498]	Q4 nPTT [>498]	P-value
Demographics
Age, years	63 (51–75)	62 (53–72)	64 (50–75)	58 (46–69)	70 (57–77)	<0.001
Sex (male), %	61%	59%	59%	59%	65%	0.95
Weight, kg	77 (65–90)	79 (66–95)	78 (69–92)	74 (61–87)	75 (63–86)	0.27
Height, m	1.72 (1.65–1.78)	1.71 (1.65–1.76)	1.72 (1.66–1.79)	1.73 (1.65–1.79)	1.72 (1.65–1.78)	0.66
Body surface area, m²	1.9 (1.7–2.1)	1.9 (1.8–2.1)	1.9 (1.8–2.1)	1.9 (1.7–2.1)	1.9 (1.7–2.1)	0.54
Body mass index, kg/m²	25.8 (22.7–29.4)	26.7 (23.2–31.4)	26.0 (23.5–29.7)	24.9 (22.1–28.3)	25.4 (22.7–28.3)	0.10
Heart rate, beats/min	59 (31–73)	30 (28–32)	35 (30–61)	67 (61–75)	77 (64–90)	<0.0001
Diabetes mellitus, %	26%	26%	23%	20%	33%	0.21
Hypercholesterolemia, %	51%	68%	38%	43%	54%	0.12
Hypertension, %	68%	76%	67%	64%	67%	0.62
History of myocardial infarction, %	68%	63%	68%	67%	73%	0.11
Aortocoronary bypass operation, %	11%	10%	7%	19%	11%	0.61
PCI, %	52%	57%	50%	48%	52%	0.30
Electrocardiogram
Sinus rhythm, %	96%	98%	98%	100%	89%	0.87
Atrial fibrillation/atrial flutter, %	4%	2%	2%	0%	11%	<0.001
Complete left bundle branch block, %	7%	7%	9%	2%	10%	0.20
Complete right bundle branch block, %	2%	2%	2%	3%	1%	0.8
CMR volumetric parameters
LVEF, %	54 (41–61)	58 (50–62)	53 (45–60)	55 (45–63)	39 (29–55)	<0.0001
RVEF, %	55 (49–61)	58 (52–62)	57 (49–60)	56 (51–61)	52 (38–60)	0.03
EDVI LV, mL/m²	87 (72–107)	82 (71–99)	90 (72–105)	85 (75–93)	103 (79–135)	<0.0001
EDVI RV, mL/m²	77 (66–92)	76 (65–92)	77 (66–92)	80 (71–91)	76 (64–96)	0.85
SV LV, ml	83 (68–99)	88 (70–100)	85 (70–102)	86 (74–99)	72 (61–89)	<0.001
SV RV, ml	80 (66–96)	86 (66–103)	82 (68–94)	84 (70–99)	73 (58–85)	<0.001
Myocardial mass indexed, g/m²	66 (57–83)	63 (55–74)	66 (55–80)	64 (59–74)	81 (66–99)	<0.0001
CMR late gadolinium enhancement (LGE)
Myocardial Infarction (ischemic LGE pattern)	19%	18%	17%	11%	28%	0.07
Non-ischemic fibrosis (non-ischemic LGE pattern)	21%	14%	26%	17%	26%	0.16
Final adjudicated diagnosis
Coronary artery disease, %	29%	31%	25%	25%	35%	0.53
Dilated cardiomyopathy, %	7%	6%	3%	3%	16%	<0.005
Acute (peri-) myocarditis, %	5%	1%	7%	8%	6%	0.22
Takotsubo syndrome, %	3%	0%	2%	1%	7%	0.026
Hypertrophic Cardiomyopathy, %	3%	2%	5%	0%	5%	0.22
Other cardiomyopathy, %	4%	5%	5%	6%	1%	0.46
Cardiac Sarcoidosis/amyloidosis, %	1%	0%	0%	1%	2%	0.30
Normal CMR Scan, %	36%	50%	35%	43%	15%	<0.001
Unclear diagnosis, %	10%	6%	14%	10%	9%	0.40
Other, %	3%	0%	5%	2%	5%	0.22

All patients (n = 353)

Q1 nPTT [<244]

Q2 nPTT [244–410]

Q3 nPTT [410–498]

Q4 nPTT [>498]

P-value

Demographics

Age, years

63 (51–75)

62 (53–72)

64 (50–75)

58 (46–69)

70 (57–77)

<0.001

Sex (male), %

61%

59%

65%

0.95

Weight, kg

77 (65–90)

79 (66–95)

78 (69–92)

74 (61–87)

75 (63–86)

0.27

Height, m

1.72 (1.65–1.78)

1.71 (1.65–1.76)

1.72 (1.66–1.79)

1.73 (1.65–1.79)

1.72 (1.65–1.78)

0.66

Body surface area, m²

1.9 (1.7–2.1)

1.9 (1.8–2.1)

1.9 (1.7–2.1)

0.54

Body mass index, kg/m²

25.8 (22.7–29.4)

26.7 (23.2–31.4)

26.0 (23.5–29.7)

24.9 (22.1–28.3)

25.4 (22.7–28.3)

0.10

Heart rate, beats/min

59 (31–73)

30 (28–32)

35 (30–61)

67 (61–75)

77 (64–90)

<0.0001

Diabetes mellitus, %

26%

23%

20%

33%

0.21

Hypercholesterolemia, %

51%

68%

38%

43%

54%

0.12

Hypertension, %

68%

76%

67%

64%

67%

0.62

History of myocardial infarction, %

68%

63%

68%

67%

73%

0.11

Aortocoronary bypass operation, %

11%

10%

19%

11%

0.61

PCI, %

52%

57%

50%

48%

52%

0.30

Electrocardiogram

Sinus rhythm, %

96%

98%

100%

89%

0.87

Atrial fibrillation/atrial flutter, %

11%

<0.001

Complete left bundle branch block, %

10%

0.20

Complete right bundle branch block, %

0.8

CMR volumetric parameters

LVEF, %

54 (41–61)

58 (50–62)

53 (45–60)

55 (45–63)

39 (29–55)

<0.0001

RVEF, %

55 (49–61)

58 (52–62)

57 (49–60)

56 (51–61)

52 (38–60)

0.03

EDVI LV, mL/m²

87 (72–107)

82 (71–99)

90 (72–105)

85 (75–93)

103 (79–135)

<0.0001

EDVI RV, mL/m²

77 (66–92)

76 (65–92)

77 (66–92)

80 (71–91)

76 (64–96)

0.85

SV LV, ml

83 (68–99)

88 (70–100)

85 (70–102)

86 (74–99)

72 (61–89)

<0.001

SV RV, ml

80 (66–96)

86 (66–103)

82 (68–94)

84 (70–99)

73 (58–85)

<0.001

Myocardial mass indexed, g/m²

66 (57–83)

63 (55–74)

66 (55–80)

64 (59–74)

81 (66–99)

<0.0001

CMR late gadolinium enhancement (LGE)

Myocardial Infarction (ischemic LGE pattern)

19%

18%

17%

11%

28%

0.07

Non-ischemic fibrosis (non-ischemic LGE pattern)

21%

14%

26%

17%

26%

0.16

Final adjudicated diagnosis

Coronary artery disease, %

29%

31%

25%

35%

0.53

Dilated cardiomyopathy, %

16%

<0.005

Acute (peri-) myocarditis, %

0.22

Takotsubo syndrome, %

0.026

Hypertrophic Cardiomyopathy, %

0.22

Other cardiomyopathy, %

0.46

Cardiac Sarcoidosis/amyloidosis, %

0.30

Normal CMR Scan, %

36%

50%

35%

43%

15%

<0.001

Unclear diagnosis, %

10%

14%

10%

0.40

Other, %

0.22

	All patients (n = 353)	Q1 nPTT [<244]	Q2 nPTT [244–410]	Q3 nPTT [410–498]	Q4 nPTT [>498]	P-value
Demographics
Age, years	63 (51–75)	62 (53–72)	64 (50–75)	58 (46–69)	70 (57–77)	<0.001
Sex (male), %	61%	59%	59%	59%	65%	0.95
Weight, kg	77 (65–90)	79 (66–95)	78 (69–92)	74 (61–87)	75 (63–86)	0.27
Height, m	1.72 (1.65–1.78)	1.71 (1.65–1.76)	1.72 (1.66–1.79)	1.73 (1.65–1.79)	1.72 (1.65–1.78)	0.66
Body surface area, m²	1.9 (1.7–2.1)	1.9 (1.8–2.1)	1.9 (1.8–2.1)	1.9 (1.7–2.1)	1.9 (1.7–2.1)	0.54
Body mass index, kg/m²	25.8 (22.7–29.4)	26.7 (23.2–31.4)	26.0 (23.5–29.7)	24.9 (22.1–28.3)	25.4 (22.7–28.3)	0.10
Heart rate, beats/min	59 (31–73)	30 (28–32)	35 (30–61)	67 (61–75)	77 (64–90)	<0.0001
Diabetes mellitus, %	26%	26%	23%	20%	33%	0.21
Hypercholesterolemia, %	51%	68%	38%	43%	54%	0.12
Hypertension, %	68%	76%	67%	64%	67%	0.62
History of myocardial infarction, %	68%	63%	68%	67%	73%	0.11
Aortocoronary bypass operation, %	11%	10%	7%	19%	11%	0.61
PCI, %	52%	57%	50%	48%	52%	0.30
Electrocardiogram
Sinus rhythm, %	96%	98%	98%	100%	89%	0.87
Atrial fibrillation/atrial flutter, %	4%	2%	2%	0%	11%	<0.001
Complete left bundle branch block, %	7%	7%	9%	2%	10%	0.20
Complete right bundle branch block, %	2%	2%	2%	3%	1%	0.8
CMR volumetric parameters
LVEF, %	54 (41–61)	58 (50–62)	53 (45–60)	55 (45–63)	39 (29–55)	<0.0001
RVEF, %	55 (49–61)	58 (52–62)	57 (49–60)	56 (51–61)	52 (38–60)	0.03
EDVI LV, mL/m²	87 (72–107)	82 (71–99)	90 (72–105)	85 (75–93)	103 (79–135)	<0.0001
EDVI RV, mL/m²	77 (66–92)	76 (65–92)	77 (66–92)	80 (71–91)	76 (64–96)	0.85
SV LV, ml	83 (68–99)	88 (70–100)	85 (70–102)	86 (74–99)	72 (61–89)	<0.001
SV RV, ml	80 (66–96)	86 (66–103)	82 (68–94)	84 (70–99)	73 (58–85)	<0.001
Myocardial mass indexed, g/m²	66 (57–83)	63 (55–74)	66 (55–80)	64 (59–74)	81 (66–99)	<0.0001
CMR late gadolinium enhancement (LGE)
Myocardial Infarction (ischemic LGE pattern)	19%	18%	17%	11%	28%	0.07
Non-ischemic fibrosis (non-ischemic LGE pattern)	21%	14%	26%	17%	26%	0.16
Final adjudicated diagnosis
Coronary artery disease, %	29%	31%	25%	25%	35%	0.53
Dilated cardiomyopathy, %	7%	6%	3%	3%	16%	<0.005
Acute (peri-) myocarditis, %	5%	1%	7%	8%	6%	0.22
Takotsubo syndrome, %	3%	0%	2%	1%	7%	0.026
Hypertrophic Cardiomyopathy, %	3%	2%	5%	0%	5%	0.22
Other cardiomyopathy, %	4%	5%	5%	6%	1%	0.46
Cardiac Sarcoidosis/amyloidosis, %	1%	0%	0%	1%	2%	0.30
Normal CMR Scan, %	36%	50%	35%	43%	15%	<0.001
Unclear diagnosis, %	10%	6%	14%	10%	9%	0.40
Other, %	3%	0%	5%	2%	5%	0.22

All patients (n = 353)

Q1 nPTT [<244]

Q2 nPTT [244–410]

Q3 nPTT [410–498]

Q4 nPTT [>498]

P-value

Demographics

Age, years

63 (51–75)

62 (53–72)

64 (50–75)

58 (46–69)

70 (57–77)

<0.001

Sex (male), %

61%

59%

65%

0.95

Weight, kg

77 (65–90)

79 (66–95)

78 (69–92)

74 (61–87)

75 (63–86)

0.27

Height, m

1.72 (1.65–1.78)

1.71 (1.65–1.76)

1.72 (1.66–1.79)

1.73 (1.65–1.79)

1.72 (1.65–1.78)

0.66

Body surface area, m²

1.9 (1.7–2.1)

1.9 (1.8–2.1)

1.9 (1.7–2.1)

0.54

Body mass index, kg/m²

25.8 (22.7–29.4)

26.7 (23.2–31.4)

26.0 (23.5–29.7)

24.9 (22.1–28.3)

25.4 (22.7–28.3)

0.10

Heart rate, beats/min

59 (31–73)

30 (28–32)

35 (30–61)

67 (61–75)

77 (64–90)

<0.0001

Diabetes mellitus, %

26%

23%

20%

33%

0.21

Hypercholesterolemia, %

51%

68%

38%

43%

54%

0.12

Hypertension, %

68%

76%

67%

64%

67%

0.62

History of myocardial infarction, %

68%

63%

68%

67%

73%

0.11

Aortocoronary bypass operation, %

11%

10%

19%

11%

0.61

PCI, %

52%

57%

50%

48%

52%

0.30

Electrocardiogram

Sinus rhythm, %

96%

98%

100%

89%

0.87

Atrial fibrillation/atrial flutter, %

11%

<0.001

Complete left bundle branch block, %

10%

0.20

Complete right bundle branch block, %

0.8

CMR volumetric parameters

LVEF, %

54 (41–61)

58 (50–62)

53 (45–60)

55 (45–63)

39 (29–55)

<0.0001

RVEF, %

55 (49–61)

58 (52–62)

57 (49–60)

56 (51–61)

52 (38–60)

0.03

EDVI LV, mL/m²

87 (72–107)

82 (71–99)

90 (72–105)

85 (75–93)

103 (79–135)

<0.0001

EDVI RV, mL/m²

77 (66–92)

76 (65–92)

77 (66–92)

80 (71–91)

76 (64–96)

0.85

SV LV, ml

83 (68–99)

88 (70–100)

85 (70–102)

86 (74–99)

72 (61–89)

<0.001

SV RV, ml

80 (66–96)

86 (66–103)

82 (68–94)

84 (70–99)

73 (58–85)

<0.001

Myocardial mass indexed, g/m²

66 (57–83)

63 (55–74)

66 (55–80)

64 (59–74)

81 (66–99)

<0.0001

CMR late gadolinium enhancement (LGE)

Myocardial Infarction (ischemic LGE pattern)

19%

18%

17%

11%

28%

0.07

Non-ischemic fibrosis (non-ischemic LGE pattern)

21%

14%

26%

17%

26%

0.16

Final adjudicated diagnosis

Coronary artery disease, %

29%

31%

25%

35%

0.53

Dilated cardiomyopathy, %

16%

<0.005

Acute (peri-) myocarditis, %

0.22

Takotsubo syndrome, %

0.026

Hypertrophic Cardiomyopathy, %

0.22

Other cardiomyopathy, %

0.46

Cardiac Sarcoidosis/amyloidosis, %

0.30

Normal CMR Scan, %

36%

50%

35%

43%

15%

<0.001

Unclear diagnosis, %

10%

14%

10%

0.40

Other, %

0.22

Table 1

Open in new tab

Baseline characteristics of all patients and relating to pulmonary transition time (nPTT) quartiles

	All patients (n = 353)	Q1 nPTT [<244]	Q2 nPTT [244–410]	Q3 nPTT [410–498]	Q4 nPTT [>498]	P-value
Demographics
Age, years	63 (51–75)	62 (53–72)	64 (50–75)	58 (46–69)	70 (57–77)	<0.001
Sex (male), %	61%	59%	59%	59%	65%	0.95
Weight, kg	77 (65–90)	79 (66–95)	78 (69–92)	74 (61–87)	75 (63–86)	0.27
Height, m	1.72 (1.65–1.78)	1.71 (1.65–1.76)	1.72 (1.66–1.79)	1.73 (1.65–1.79)	1.72 (1.65–1.78)	0.66
Body surface area, m²	1.9 (1.7–2.1)	1.9 (1.8–2.1)	1.9 (1.8–2.1)	1.9 (1.7–2.1)	1.9 (1.7–2.1)	0.54
Body mass index, kg/m²	25.8 (22.7–29.4)	26.7 (23.2–31.4)	26.0 (23.5–29.7)	24.9 (22.1–28.3)	25.4 (22.7–28.3)	0.10
Heart rate, beats/min	59 (31–73)	30 (28–32)	35 (30–61)	67 (61–75)	77 (64–90)	<0.0001
Diabetes mellitus, %	26%	26%	23%	20%	33%	0.21
Hypercholesterolemia, %	51%	68%	38%	43%	54%	0.12
Hypertension, %	68%	76%	67%	64%	67%	0.62
History of myocardial infarction, %	68%	63%	68%	67%	73%	0.11
Aortocoronary bypass operation, %	11%	10%	7%	19%	11%	0.61
PCI, %	52%	57%	50%	48%	52%	0.30
Electrocardiogram
Sinus rhythm, %	96%	98%	98%	100%	89%	0.87
Atrial fibrillation/atrial flutter, %	4%	2%	2%	0%	11%	<0.001
Complete left bundle branch block, %	7%	7%	9%	2%	10%	0.20
Complete right bundle branch block, %	2%	2%	2%	3%	1%	0.8
CMR volumetric parameters
LVEF, %	54 (41–61)	58 (50–62)	53 (45–60)	55 (45–63)	39 (29–55)	<0.0001
RVEF, %	55 (49–61)	58 (52–62)	57 (49–60)	56 (51–61)	52 (38–60)	0.03
EDVI LV, mL/m²	87 (72–107)	82 (71–99)	90 (72–105)	85 (75–93)	103 (79–135)	<0.0001
EDVI RV, mL/m²	77 (66–92)	76 (65–92)	77 (66–92)	80 (71–91)	76 (64–96)	0.85
SV LV, ml	83 (68–99)	88 (70–100)	85 (70–102)	86 (74–99)	72 (61–89)	<0.001
SV RV, ml	80 (66–96)	86 (66–103)	82 (68–94)	84 (70–99)	73 (58–85)	<0.001
Myocardial mass indexed, g/m²	66 (57–83)	63 (55–74)	66 (55–80)	64 (59–74)	81 (66–99)	<0.0001
CMR late gadolinium enhancement (LGE)
Myocardial Infarction (ischemic LGE pattern)	19%	18%	17%	11%	28%	0.07
Non-ischemic fibrosis (non-ischemic LGE pattern)	21%	14%	26%	17%	26%	0.16
Final adjudicated diagnosis
Coronary artery disease, %	29%	31%	25%	25%	35%	0.53
Dilated cardiomyopathy, %	7%	6%	3%	3%	16%	<0.005
Acute (peri-) myocarditis, %	5%	1%	7%	8%	6%	0.22
Takotsubo syndrome, %	3%	0%	2%	1%	7%	0.026
Hypertrophic Cardiomyopathy, %	3%	2%	5%	0%	5%	0.22
Other cardiomyopathy, %	4%	5%	5%	6%	1%	0.46
Cardiac Sarcoidosis/amyloidosis, %	1%	0%	0%	1%	2%	0.30
Normal CMR Scan, %	36%	50%	35%	43%	15%	<0.001
Unclear diagnosis, %	10%	6%	14%	10%	9%	0.40
Other, %	3%	0%	5%	2%	5%	0.22

	All patients (n = 353)	Q1 nPTT [<244]	Q2 nPTT [244–410]	Q3 nPTT [410–498]	Q4 nPTT [>498]	P-value
Demographics
Age, years	63 (51–75)	62 (53–72)	64 (50–75)	58 (46–69)	70 (57–77)	<0.001
Sex (male), %	61%	59%	59%	59%	65%	0.95
Weight, kg	77 (65–90)	79 (66–95)	78 (69–92)	74 (61–87)	75 (63–86)	0.27
Height, m	1.72 (1.65–1.78)	1.71 (1.65–1.76)	1.72 (1.66–1.79)	1.73 (1.65–1.79)	1.72 (1.65–1.78)	0.66
Body surface area, m²	1.9 (1.7–2.1)	1.9 (1.8–2.1)	1.9 (1.8–2.1)	1.9 (1.7–2.1)	1.9 (1.7–2.1)	0.54
Body mass index, kg/m²	25.8 (22.7–29.4)	26.7 (23.2–31.4)	26.0 (23.5–29.7)	24.9 (22.1–28.3)	25.4 (22.7–28.3)	0.10
Heart rate, beats/min	59 (31–73)	30 (28–32)	35 (30–61)	67 (61–75)	77 (64–90)	<0.0001
Diabetes mellitus, %	26%	26%	23%	20%	33%	0.21
Hypercholesterolemia, %	51%	68%	38%	43%	54%	0.12
Hypertension, %	68%	76%	67%	64%	67%	0.62
History of myocardial infarction, %	68%	63%	68%	67%	73%	0.11
Aortocoronary bypass operation, %	11%	10%	7%	19%	11%	0.61
PCI, %	52%	57%	50%	48%	52%	0.30
Electrocardiogram
Sinus rhythm, %	96%	98%	98%	100%	89%	0.87
Atrial fibrillation/atrial flutter, %	4%	2%	2%	0%	11%	<0.001
Complete left bundle branch block, %	7%	7%	9%	2%	10%	0.20
Complete right bundle branch block, %	2%	2%	2%	3%	1%	0.8
CMR volumetric parameters
LVEF, %	54 (41–61)	58 (50–62)	53 (45–60)	55 (45–63)	39 (29–55)	<0.0001
RVEF, %	55 (49–61)	58 (52–62)	57 (49–60)	56 (51–61)	52 (38–60)	0.03
EDVI LV, mL/m²	87 (72–107)	82 (71–99)	90 (72–105)	85 (75–93)	103 (79–135)	<0.0001
EDVI RV, mL/m²	77 (66–92)	76 (65–92)	77 (66–92)	80 (71–91)	76 (64–96)	0.85
SV LV, ml	83 (68–99)	88 (70–100)	85 (70–102)	86 (74–99)	72 (61–89)	<0.001
SV RV, ml	80 (66–96)	86 (66–103)	82 (68–94)	84 (70–99)	73 (58–85)	<0.001
Myocardial mass indexed, g/m²	66 (57–83)	63 (55–74)	66 (55–80)	64 (59–74)	81 (66–99)	<0.0001
CMR late gadolinium enhancement (LGE)
Myocardial Infarction (ischemic LGE pattern)	19%	18%	17%	11%	28%	0.07
Non-ischemic fibrosis (non-ischemic LGE pattern)	21%	14%	26%	17%	26%	0.16
Final adjudicated diagnosis
Coronary artery disease, %	29%	31%	25%	25%	35%	0.53
Dilated cardiomyopathy, %	7%	6%	3%	3%	16%	<0.005
Acute (peri-) myocarditis, %	5%	1%	7%	8%	6%	0.22
Takotsubo syndrome, %	3%	0%	2%	1%	7%	0.026
Hypertrophic Cardiomyopathy, %	3%	2%	5%	0%	5%	0.22
Other cardiomyopathy, %	4%	5%	5%	6%	1%	0.46
Cardiac Sarcoidosis/amyloidosis, %	1%	0%	0%	1%	2%	0.30
Normal CMR Scan, %	36%	50%	35%	43%	15%	<0.001
Unclear diagnosis, %	10%	6%	14%	10%	9%	0.40
Other, %	3%	0%	5%	2%	5%	0.22

Values are displayed as median [interquartile range] or %.

CMR, cardiovascular magnetic resonance; LVEF, left ventricular ejection fraction; RVEF, right ventricular ejection fraction; EDVI, end-diastolic volume indexed; LV, left ventricle; RV, right ventricle; PCI, percutaneous coronary intervention; Information about comorbidities were available for 58% of patients. Continuous variables with a significant group comparison are itemized in Supplementary material online, Figure S1.

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