| Patient . | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . |
|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 60 | 63 | 85 | 56 | 77 | 76 | 63 | 64 | 68 |
| Gender | F | M | F | M | F | F | F | F | F |
| RT-QuIC | + | + | + | + | + | NC | + | + | − |
| 14-3-3 | Inconclusive | + | − | + | + | + | + | + | + |
| EEG | PSWC | PSWC | PSWC | PSWC | PSWC | PSWC | |||
| MRI | + | + | + | + | + | − | + | + | + |
| Patient . | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . |
|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 60 | 63 | 85 | 56 | 77 | 76 | 63 | 64 | 68 |
| Gender | F | M | F | M | F | F | F | F | F |
| RT-QuIC | + | + | + | + | + | NC | + | + | − |
| 14-3-3 | Inconclusive | + | − | + | + | + | + | + | + |
| EEG | PSWC | PSWC | PSWC | PSWC | PSWC | PSWC | |||
| MRI | + | + | + | + | + | − | + | + | + |
Abbreviations: + = positive; − = negative; EEG = electroencephalography; NC = not collected; PSWC = periodic sharp wave complex; real-time quaking-induced conversion (RT-QuIC) and 14-3-3 collected from cerebrospinal fluid (CSF); magnetic resonance imaging (MRI) positive findings refer to presence of diffusion restriction in cortical hemispheres (cortical ribboning), lentiform nuclei, and medial thalami; Patient 7 had caudate biopsy showing spongiform degeneration.
| Patient . | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . |
|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 60 | 63 | 85 | 56 | 77 | 76 | 63 | 64 | 68 |
| Gender | F | M | F | M | F | F | F | F | F |
| RT-QuIC | + | + | + | + | + | NC | + | + | − |
| 14-3-3 | Inconclusive | + | − | + | + | + | + | + | + |
| EEG | PSWC | PSWC | PSWC | PSWC | PSWC | PSWC | |||
| MRI | + | + | + | + | + | − | + | + | + |
| Patient . | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | 7 . | 8 . | 9 . |
|---|---|---|---|---|---|---|---|---|---|
| Age (years) | 60 | 63 | 85 | 56 | 77 | 76 | 63 | 64 | 68 |
| Gender | F | M | F | M | F | F | F | F | F |
| RT-QuIC | + | + | + | + | + | NC | + | + | − |
| 14-3-3 | Inconclusive | + | − | + | + | + | + | + | + |
| EEG | PSWC | PSWC | PSWC | PSWC | PSWC | PSWC | |||
| MRI | + | + | + | + | + | − | + | + | + |
Abbreviations: + = positive; − = negative; EEG = electroencephalography; NC = not collected; PSWC = periodic sharp wave complex; real-time quaking-induced conversion (RT-QuIC) and 14-3-3 collected from cerebrospinal fluid (CSF); magnetic resonance imaging (MRI) positive findings refer to presence of diffusion restriction in cortical hemispheres (cortical ribboning), lentiform nuclei, and medial thalami; Patient 7 had caudate biopsy showing spongiform degeneration.
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