Table 1

Performance of predictions on the UnifyPDBFull 5-fold test datasets

SPRIEVmutationFATHMMLISTPMUTPolyphen-2PROVEANRhapsody
Completeness1.00.7400.9870.9870.9900.9870.9870.930
Recall0.9190.9080.8680.7550.7320.8750.8420.826
Specificity0.8260.7670.3850.7440.7030.8130.8160.926
Precision0.8890.8610.6770.8140.7880.8750.8720.947
Accuracy0.8820.8540.6740.750.7210.850.8320.864
F-1 score0.9040.8840.7610.7830.7590.8750.8570.882
MCC score0.7520.6880.2930.4920.4290.6880.6540.732
SPRIEVmutationFATHMMLISTPMUTPolyphen-2PROVEANRhapsody
Completeness1.00.7400.9870.9870.9900.9870.9870.930
Recall0.9190.9080.8680.7550.7320.8750.8420.826
Specificity0.8260.7670.3850.7440.7030.8130.8160.926
Precision0.8890.8610.6770.8140.7880.8750.8720.947
Accuracy0.8820.8540.6740.750.7210.850.8320.864
F-1 score0.9040.8840.7610.7830.7590.8750.8570.882
MCC score0.7520.6880.2930.4920.4290.6880.6540.732

Bold indicates the best metric.

Table 1

Performance of predictions on the UnifyPDBFull 5-fold test datasets

SPRIEVmutationFATHMMLISTPMUTPolyphen-2PROVEANRhapsody
Completeness1.00.7400.9870.9870.9900.9870.9870.930
Recall0.9190.9080.8680.7550.7320.8750.8420.826
Specificity0.8260.7670.3850.7440.7030.8130.8160.926
Precision0.8890.8610.6770.8140.7880.8750.8720.947
Accuracy0.8820.8540.6740.750.7210.850.8320.864
F-1 score0.9040.8840.7610.7830.7590.8750.8570.882
MCC score0.7520.6880.2930.4920.4290.6880.6540.732
SPRIEVmutationFATHMMLISTPMUTPolyphen-2PROVEANRhapsody
Completeness1.00.7400.9870.9870.9900.9870.9870.930
Recall0.9190.9080.8680.7550.7320.8750.8420.826
Specificity0.8260.7670.3850.7440.7030.8130.8160.926
Precision0.8890.8610.6770.8140.7880.8750.8720.947
Accuracy0.8820.8540.6740.750.7210.850.8320.864
F-1 score0.9040.8840.7610.7830.7590.8750.8570.882
MCC score0.7520.6880.2930.4920.4290.6880.6540.732

Bold indicates the best metric.

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