Table 4.
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Response per RECIST 1.1 (N = 28).

Best responseOverall, N = 28Arm A, N = 10Arm B, N = 12Arm C, N = 6
CR1 (4%)0 (0%)1 (8%)0 (0%)
PR6 (21%)2 (20%)a2 (17%)2 (33%)
SD13 (46%)4 (40%)6 (50%)3 (50%)
PD8 (29%)4 (40%)3 (25%)1 (17%)b
ORR (CR + PR)7 (25%)2 (20%)3 (25%)2/6 (33%)c
CBR (CR + PR + SD) at 6 months10 (36%)2 (20%)5 (42%)3 (50%)
Best responseOverall, N = 28Arm A, N = 10Arm B, N = 12Arm C, N = 6
CR1 (4%)0 (0%)1 (8%)0 (0%)
PR6 (21%)2 (20%)a2 (17%)2 (33%)
SD13 (46%)4 (40%)6 (50%)3 (50%)
PD8 (29%)4 (40%)3 (25%)1 (17%)b
ORR (CR + PR)7 (25%)2 (20%)3 (25%)2/6 (33%)c
CBR (CR + PR + SD) at 6 months10 (36%)2 (20%)5 (42%)3 (50%)

aBoth at RP2D, resulting in 2/7 or (29%) at RP2D.

bPatient was HER2+ at progression.

cExcluding HER2+ patient at PD in Arm C, ORR is 2/5 (40%).

Table 4.
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Response per RECIST 1.1 (N = 28).

Best responseOverall, N = 28Arm A, N = 10Arm B, N = 12Arm C, N = 6
CR1 (4%)0 (0%)1 (8%)0 (0%)
PR6 (21%)2 (20%)a2 (17%)2 (33%)
SD13 (46%)4 (40%)6 (50%)3 (50%)
PD8 (29%)4 (40%)3 (25%)1 (17%)b
ORR (CR + PR)7 (25%)2 (20%)3 (25%)2/6 (33%)c
CBR (CR + PR + SD) at 6 months10 (36%)2 (20%)5 (42%)3 (50%)
Best responseOverall, N = 28Arm A, N = 10Arm B, N = 12Arm C, N = 6
CR1 (4%)0 (0%)1 (8%)0 (0%)
PR6 (21%)2 (20%)a2 (17%)2 (33%)
SD13 (46%)4 (40%)6 (50%)3 (50%)
PD8 (29%)4 (40%)3 (25%)1 (17%)b
ORR (CR + PR)7 (25%)2 (20%)3 (25%)2/6 (33%)c
CBR (CR + PR + SD) at 6 months10 (36%)2 (20%)5 (42%)3 (50%)

aBoth at RP2D, resulting in 2/7 or (29%) at RP2D.

bPatient was HER2+ at progression.

cExcluding HER2+ patient at PD in Arm C, ORR is 2/5 (40%).

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