Table 5:
Open in new tab

Linear regression analysis of associations between CSVD and cognitive function.

Baseline assessment (n = 119)Follow-up assessment (n = 65)
MMSEMOCAMMSEMOCA
β (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-value
CMB–1.17 (–2.07 to –0.28).01–1.10 (–2.60 to 0.41).150.28 (–1.32 to 1.89).730.40 (–1.71 to 2.50).71
 Lobar–1.29 (–2.83 to 0.25).100.26 (–2.31 to 2.83).840.33 (–2.09 to 2.74).792.74 (–0.36 to 5.83).08
 Deep–0.67 (–1.77 to 0.43).23–1.59 (–3.39 to 0.21).08–0.27 (–1.68 to 2.22).78–0.80 (–3.36 to 1.75).53
 Mixed–0.83 (–2.47 to 0.82).32–0.28 (–3.01 to 2.44).84–0.21 (–3.73 to 3.30).90–1.27 (–5.87 to 3.34).58
Lacunae–0.52 (–1.47 to 0.44).29–1.04 (–2.62 to 0.53).19–2.09 (–3.78 to –0.39).02–2.51 (–4.75 to –0.26).03
 SWM–0.45 (–1.55 to 0.63).41–1.07 (–2.84 to 0.71).24–0.71 (–2.72 to 1.29).48–1.76 (–4.36 to 0.84).18
 BG–0.89 (–1.98 to 0.21).11–0.68 (–2.50 to 1.14).46–2.43 (–4.49 to –0.36).02–3.06 (–5.78 to –0.33).03
WMH0.57 (–0.40 to 1.54).24–0.75 (–2.35 to 0.85).35–1.64 (–3.21 to –0.08).04–2.11 (–4.17 to –0.05).04
 PVWMHs0.62 (–0.39 to 1.63).23–0.60 (–2.27 to 1.07).48–1.76 (–3.37 to –0.14).03–1.72 (–3.88 to 0.44).12
 DWMHs–0.23 (–1.23 to –0.78).66–1.95 (–3.58 to –0.33).02–1.90 (–3.58 to –0.22).03–3.09 (–5.25 to –0.93).01
Baseline assessment (n = 119)Follow-up assessment (n = 65)
MMSEMOCAMMSEMOCA
β (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-value
CMB–1.17 (–2.07 to –0.28).01–1.10 (–2.60 to 0.41).150.28 (–1.32 to 1.89).730.40 (–1.71 to 2.50).71
 Lobar–1.29 (–2.83 to 0.25).100.26 (–2.31 to 2.83).840.33 (–2.09 to 2.74).792.74 (–0.36 to 5.83).08
 Deep–0.67 (–1.77 to 0.43).23–1.59 (–3.39 to 0.21).08–0.27 (–1.68 to 2.22).78–0.80 (–3.36 to 1.75).53
 Mixed–0.83 (–2.47 to 0.82).32–0.28 (–3.01 to 2.44).84–0.21 (–3.73 to 3.30).90–1.27 (–5.87 to 3.34).58
Lacunae–0.52 (–1.47 to 0.44).29–1.04 (–2.62 to 0.53).19–2.09 (–3.78 to –0.39).02–2.51 (–4.75 to –0.26).03
 SWM–0.45 (–1.55 to 0.63).41–1.07 (–2.84 to 0.71).24–0.71 (–2.72 to 1.29).48–1.76 (–4.36 to 0.84).18
 BG–0.89 (–1.98 to 0.21).11–0.68 (–2.50 to 1.14).46–2.43 (–4.49 to –0.36).02–3.06 (–5.78 to –0.33).03
WMH0.57 (–0.40 to 1.54).24–0.75 (–2.35 to 0.85).35–1.64 (–3.21 to –0.08).04–2.11 (–4.17 to –0.05).04
 PVWMHs0.62 (–0.39 to 1.63).23–0.60 (–2.27 to 1.07).48–1.76 (–3.37 to –0.14).03–1.72 (–3.88 to 0.44).12
 DWMHs–0.23 (–1.23 to –0.78).66–1.95 (–3.58 to –0.33).02–1.90 (–3.58 to –0.22).03–3.09 (–5.25 to –0.93).01

Adjusted for age, education level, blood urea nitrogen and hemoglobin.

Bold indicates P < 0.05.

Table 5:
Open in new tab

Linear regression analysis of associations between CSVD and cognitive function.

Baseline assessment (n = 119)Follow-up assessment (n = 65)
MMSEMOCAMMSEMOCA
β (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-value
CMB–1.17 (–2.07 to –0.28).01–1.10 (–2.60 to 0.41).150.28 (–1.32 to 1.89).730.40 (–1.71 to 2.50).71
 Lobar–1.29 (–2.83 to 0.25).100.26 (–2.31 to 2.83).840.33 (–2.09 to 2.74).792.74 (–0.36 to 5.83).08
 Deep–0.67 (–1.77 to 0.43).23–1.59 (–3.39 to 0.21).08–0.27 (–1.68 to 2.22).78–0.80 (–3.36 to 1.75).53
 Mixed–0.83 (–2.47 to 0.82).32–0.28 (–3.01 to 2.44).84–0.21 (–3.73 to 3.30).90–1.27 (–5.87 to 3.34).58
Lacunae–0.52 (–1.47 to 0.44).29–1.04 (–2.62 to 0.53).19–2.09 (–3.78 to –0.39).02–2.51 (–4.75 to –0.26).03
 SWM–0.45 (–1.55 to 0.63).41–1.07 (–2.84 to 0.71).24–0.71 (–2.72 to 1.29).48–1.76 (–4.36 to 0.84).18
 BG–0.89 (–1.98 to 0.21).11–0.68 (–2.50 to 1.14).46–2.43 (–4.49 to –0.36).02–3.06 (–5.78 to –0.33).03
WMH0.57 (–0.40 to 1.54).24–0.75 (–2.35 to 0.85).35–1.64 (–3.21 to –0.08).04–2.11 (–4.17 to –0.05).04
 PVWMHs0.62 (–0.39 to 1.63).23–0.60 (–2.27 to 1.07).48–1.76 (–3.37 to –0.14).03–1.72 (–3.88 to 0.44).12
 DWMHs–0.23 (–1.23 to –0.78).66–1.95 (–3.58 to –0.33).02–1.90 (–3.58 to –0.22).03–3.09 (–5.25 to –0.93).01
Baseline assessment (n = 119)Follow-up assessment (n = 65)
MMSEMOCAMMSEMOCA
β (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-valueβ (95% CI)P-value
CMB–1.17 (–2.07 to –0.28).01–1.10 (–2.60 to 0.41).150.28 (–1.32 to 1.89).730.40 (–1.71 to 2.50).71
 Lobar–1.29 (–2.83 to 0.25).100.26 (–2.31 to 2.83).840.33 (–2.09 to 2.74).792.74 (–0.36 to 5.83).08
 Deep–0.67 (–1.77 to 0.43).23–1.59 (–3.39 to 0.21).08–0.27 (–1.68 to 2.22).78–0.80 (–3.36 to 1.75).53
 Mixed–0.83 (–2.47 to 0.82).32–0.28 (–3.01 to 2.44).84–0.21 (–3.73 to 3.30).90–1.27 (–5.87 to 3.34).58
Lacunae–0.52 (–1.47 to 0.44).29–1.04 (–2.62 to 0.53).19–2.09 (–3.78 to –0.39).02–2.51 (–4.75 to –0.26).03
 SWM–0.45 (–1.55 to 0.63).41–1.07 (–2.84 to 0.71).24–0.71 (–2.72 to 1.29).48–1.76 (–4.36 to 0.84).18
 BG–0.89 (–1.98 to 0.21).11–0.68 (–2.50 to 1.14).46–2.43 (–4.49 to –0.36).02–3.06 (–5.78 to –0.33).03
WMH0.57 (–0.40 to 1.54).24–0.75 (–2.35 to 0.85).35–1.64 (–3.21 to –0.08).04–2.11 (–4.17 to –0.05).04
 PVWMHs0.62 (–0.39 to 1.63).23–0.60 (–2.27 to 1.07).48–1.76 (–3.37 to –0.14).03–1.72 (–3.88 to 0.44).12
 DWMHs–0.23 (–1.23 to –0.78).66–1.95 (–3.58 to –0.33).02–1.90 (–3.58 to –0.22).03–3.09 (–5.25 to –0.93).01

Adjusted for age, education level, blood urea nitrogen and hemoglobin.

Bold indicates P < 0.05.

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