Demographic parameters, serum biomarkers and serum levels of miR-145 and miR-486 in general population with different degree of aortic calcification (EVOS) (Phase 3b).
| . | No VC (n = 39) . | Mild VC (n = 16) . | Severe VC (n = 21) . | P . |
|---|---|---|---|---|
| Age (years) (mean ± SD) | 61.61 ± 6.82 | 62.89 ± 8.16 | 64.85 ± 7.07 | .257 |
| Sex (males %) | 38.46 | 50.00 | 47.62 | .663 |
| BMI (Kg/m2) (mean ± SD) | 27.34 ± 4.09 | 27.34 ± 3.17 | 27.55 ± 3.40 | .975 |
| Smokers (%) | 12.82 | 26.67 | 28.57 | .267 |
| Ca (mg/dL) (mean ± SD) | 9.35 ± 0.32 | 9.29 ± 0.33 | 9.47 ± 0.28 | .189 |
| P (mg/dL) (mean ± SD) | 3.55 ± 0.41 | 3.54 ± 0.52 | 3.57 ± 0.39 | .978 |
| PTH (pg/mL) [median (IQR)] | 44.00 (33.50–59.00) | 49.00 (34.75–80.00) | 54 (47.00–63.00) | .103 |
| miR-145 (RU) [median (IQR)] | 1.00 (0.23–5.69) | 0.04 (0.02–0.45)* | 0.02 (0.006–0.12)*** | <.001 |
| miR-486 (RU) [median (IQR)] | 1.00 (0.41–6.28) | 0.49 (0.19–1.61) | 0.05 (0.01–1.43)*** | .003 |
| . | No VC (n = 39) . | Mild VC (n = 16) . | Severe VC (n = 21) . | P . |
|---|---|---|---|---|
| Age (years) (mean ± SD) | 61.61 ± 6.82 | 62.89 ± 8.16 | 64.85 ± 7.07 | .257 |
| Sex (males %) | 38.46 | 50.00 | 47.62 | .663 |
| BMI (Kg/m2) (mean ± SD) | 27.34 ± 4.09 | 27.34 ± 3.17 | 27.55 ± 3.40 | .975 |
| Smokers (%) | 12.82 | 26.67 | 28.57 | .267 |
| Ca (mg/dL) (mean ± SD) | 9.35 ± 0.32 | 9.29 ± 0.33 | 9.47 ± 0.28 | .189 |
| P (mg/dL) (mean ± SD) | 3.55 ± 0.41 | 3.54 ± 0.52 | 3.57 ± 0.39 | .978 |
| PTH (pg/mL) [median (IQR)] | 44.00 (33.50–59.00) | 49.00 (34.75–80.00) | 54 (47.00–63.00) | .103 |
| miR-145 (RU) [median (IQR)] | 1.00 (0.23–5.69) | 0.04 (0.02–0.45)* | 0.02 (0.006–0.12)*** | <.001 |
| miR-486 (RU) [median (IQR)] | 1.00 (0.41–6.28) | 0.49 (0.19–1.61) | 0.05 (0.01–1.43)*** | .003 |
n, number of patients available. Data represent percentage (%), median (IQR) or mean ± SD. *P < .05, ***P < .001 versus no VC group.
Demographic parameters, serum biomarkers and serum levels of miR-145 and miR-486 in general population with different degree of aortic calcification (EVOS) (Phase 3b).
| . | No VC (n = 39) . | Mild VC (n = 16) . | Severe VC (n = 21) . | P . |
|---|---|---|---|---|
| Age (years) (mean ± SD) | 61.61 ± 6.82 | 62.89 ± 8.16 | 64.85 ± 7.07 | .257 |
| Sex (males %) | 38.46 | 50.00 | 47.62 | .663 |
| BMI (Kg/m2) (mean ± SD) | 27.34 ± 4.09 | 27.34 ± 3.17 | 27.55 ± 3.40 | .975 |
| Smokers (%) | 12.82 | 26.67 | 28.57 | .267 |
| Ca (mg/dL) (mean ± SD) | 9.35 ± 0.32 | 9.29 ± 0.33 | 9.47 ± 0.28 | .189 |
| P (mg/dL) (mean ± SD) | 3.55 ± 0.41 | 3.54 ± 0.52 | 3.57 ± 0.39 | .978 |
| PTH (pg/mL) [median (IQR)] | 44.00 (33.50–59.00) | 49.00 (34.75–80.00) | 54 (47.00–63.00) | .103 |
| miR-145 (RU) [median (IQR)] | 1.00 (0.23–5.69) | 0.04 (0.02–0.45)* | 0.02 (0.006–0.12)*** | <.001 |
| miR-486 (RU) [median (IQR)] | 1.00 (0.41–6.28) | 0.49 (0.19–1.61) | 0.05 (0.01–1.43)*** | .003 |
| . | No VC (n = 39) . | Mild VC (n = 16) . | Severe VC (n = 21) . | P . |
|---|---|---|---|---|
| Age (years) (mean ± SD) | 61.61 ± 6.82 | 62.89 ± 8.16 | 64.85 ± 7.07 | .257 |
| Sex (males %) | 38.46 | 50.00 | 47.62 | .663 |
| BMI (Kg/m2) (mean ± SD) | 27.34 ± 4.09 | 27.34 ± 3.17 | 27.55 ± 3.40 | .975 |
| Smokers (%) | 12.82 | 26.67 | 28.57 | .267 |
| Ca (mg/dL) (mean ± SD) | 9.35 ± 0.32 | 9.29 ± 0.33 | 9.47 ± 0.28 | .189 |
| P (mg/dL) (mean ± SD) | 3.55 ± 0.41 | 3.54 ± 0.52 | 3.57 ± 0.39 | .978 |
| PTH (pg/mL) [median (IQR)] | 44.00 (33.50–59.00) | 49.00 (34.75–80.00) | 54 (47.00–63.00) | .103 |
| miR-145 (RU) [median (IQR)] | 1.00 (0.23–5.69) | 0.04 (0.02–0.45)* | 0.02 (0.006–0.12)*** | <.001 |
| miR-486 (RU) [median (IQR)] | 1.00 (0.41–6.28) | 0.49 (0.19–1.61) | 0.05 (0.01–1.43)*** | .003 |
n, number of patients available. Data represent percentage (%), median (IQR) or mean ± SD. *P < .05, ***P < .001 versus no VC group.
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