Associations of obesity metrics (as continuous variables) with incident CVDs and mortality outcomes
| Incident disease . | BMI (log) . | WHR . | ||||
|---|---|---|---|---|---|---|
| Model 1 . | Model 2 . | Model 3 . | Model 1 . | Model 2 . | Model 3 . | |
| Any CVD | 1.33* | 1.30* | 1.22* | 1.38* | 1.33* | 1.22* |
| [1.32, 1.34] | [1.29, 1.32] | [1.20, 1.23] | [1.37, 1.40] | [1.31, 1.34] | [1.20, 1.23] | |
| <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | 7.05 × 10−225 | |
| Ischaemic heart disease | 1.33* | 1.29* | 1.18* | 1.46* | 1.38* | 1.24* |
| [1.31, 1.34] | [1.27, 1.30] | [1.16, 1.19] | [1.44, 1.48] | [1.36, 1.40] | [1.22, 1.26] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 1.89 × 10−155 | <1.0 × 10−300 | <1.0 × 10−300 | 3.17 × 10−166 | |
| Atrial fibrillation | 1.36* | 1.35* | 1.27* | 1.30* | 1.27* | 1.18* |
| [1.35, 1.38] | [1.33, 1.37] | [1.25, 1.28] | [1.28, 1.32] | [1.25, 1.29] | [1.16, 1.20] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.11 × 10−281 | 8.66 × 10−239 | 2.85 × 10−190 | 1.04 × 10−80 | |
| Heart failure | 1.59* | 1.52* | 1.34* | 1.67* | 1.54* | 1.33* |
| [1.57, 1.62] | [1.49, 1.54] | [1.32, 1.37] | [1.64, 1.71] | [1.51, 1.57] | [1.30, 1.36] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.43 × 10−237 | <1.0 × 10−300 | <1.0 × 10−300 | 7.38 × 10−132 | |
| All-cause mortality | 1.17* | 1.12* | 1.05* | 1.39* | 1.28* | 1.19* |
| [1.16, 1.18] | [1.11, 1.14] | [1.03, 1.06] | [1.37, 1.41] | [1.27, 1.30] | [1.18, 1.21] | |
| 1.51 × 10−174 | 4.74 × 10−91 | 1.49 × 10−13 | <1.0 × 10−300 | 1.15 × 10–256 | 1.76 × 10−119 | |
| CVD mortality | 1.56* | 1.46* | 1.23* | 1.80* | 1.61* | 1.32* |
| [1.51, 1.61] | [1.42, 1.51] | [1.19, 1.27] | [1.73, 1.87] | [1.55, 1.68] | [1.26, 1.38] | |
| 5.19 × 10−176 | 2.38 × 10−127 | 3.38 × 10−34 | 1.09 × 10−199 | 2.17 × 10−121 | 1.74 × 10−37 | |
| Incident disease . | BMI (log) . | WHR . | ||||
|---|---|---|---|---|---|---|
| Model 1 . | Model 2 . | Model 3 . | Model 1 . | Model 2 . | Model 3 . | |
| Any CVD | 1.33* | 1.30* | 1.22* | 1.38* | 1.33* | 1.22* |
| [1.32, 1.34] | [1.29, 1.32] | [1.20, 1.23] | [1.37, 1.40] | [1.31, 1.34] | [1.20, 1.23] | |
| <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | 7.05 × 10−225 | |
| Ischaemic heart disease | 1.33* | 1.29* | 1.18* | 1.46* | 1.38* | 1.24* |
| [1.31, 1.34] | [1.27, 1.30] | [1.16, 1.19] | [1.44, 1.48] | [1.36, 1.40] | [1.22, 1.26] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 1.89 × 10−155 | <1.0 × 10−300 | <1.0 × 10−300 | 3.17 × 10−166 | |
| Atrial fibrillation | 1.36* | 1.35* | 1.27* | 1.30* | 1.27* | 1.18* |
| [1.35, 1.38] | [1.33, 1.37] | [1.25, 1.28] | [1.28, 1.32] | [1.25, 1.29] | [1.16, 1.20] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.11 × 10−281 | 8.66 × 10−239 | 2.85 × 10−190 | 1.04 × 10−80 | |
| Heart failure | 1.59* | 1.52* | 1.34* | 1.67* | 1.54* | 1.33* |
| [1.57, 1.62] | [1.49, 1.54] | [1.32, 1.37] | [1.64, 1.71] | [1.51, 1.57] | [1.30, 1.36] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.43 × 10−237 | <1.0 × 10−300 | <1.0 × 10−300 | 7.38 × 10−132 | |
| All-cause mortality | 1.17* | 1.12* | 1.05* | 1.39* | 1.28* | 1.19* |
| [1.16, 1.18] | [1.11, 1.14] | [1.03, 1.06] | [1.37, 1.41] | [1.27, 1.30] | [1.18, 1.21] | |
| 1.51 × 10−174 | 4.74 × 10−91 | 1.49 × 10−13 | <1.0 × 10−300 | 1.15 × 10–256 | 1.76 × 10−119 | |
| CVD mortality | 1.56* | 1.46* | 1.23* | 1.80* | 1.61* | 1.32* |
| [1.51, 1.61] | [1.42, 1.51] | [1.19, 1.27] | [1.73, 1.87] | [1.55, 1.68] | [1.26, 1.38] | |
| 5.19 × 10−176 | 2.38 × 10−127 | 3.38 × 10−34 | 1.09 × 10−199 | 2.17 × 10−121 | 1.74 × 10−37 | |
Results are HRs associated with 1 SD increase in obesity [BMI (log) or WHR], 95% CIs, and P-values from Cox models relating the exposures to incident disease/events in the full sample. One SD BMI (log) = 4.4 kg/m2 and 1 SD WHR = 0.09.
*Represent significant associations.
Associations of obesity metrics (as continuous variables) with incident CVDs and mortality outcomes
| Incident disease . | BMI (log) . | WHR . | ||||
|---|---|---|---|---|---|---|
| Model 1 . | Model 2 . | Model 3 . | Model 1 . | Model 2 . | Model 3 . | |
| Any CVD | 1.33* | 1.30* | 1.22* | 1.38* | 1.33* | 1.22* |
| [1.32, 1.34] | [1.29, 1.32] | [1.20, 1.23] | [1.37, 1.40] | [1.31, 1.34] | [1.20, 1.23] | |
| <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | 7.05 × 10−225 | |
| Ischaemic heart disease | 1.33* | 1.29* | 1.18* | 1.46* | 1.38* | 1.24* |
| [1.31, 1.34] | [1.27, 1.30] | [1.16, 1.19] | [1.44, 1.48] | [1.36, 1.40] | [1.22, 1.26] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 1.89 × 10−155 | <1.0 × 10−300 | <1.0 × 10−300 | 3.17 × 10−166 | |
| Atrial fibrillation | 1.36* | 1.35* | 1.27* | 1.30* | 1.27* | 1.18* |
| [1.35, 1.38] | [1.33, 1.37] | [1.25, 1.28] | [1.28, 1.32] | [1.25, 1.29] | [1.16, 1.20] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.11 × 10−281 | 8.66 × 10−239 | 2.85 × 10−190 | 1.04 × 10−80 | |
| Heart failure | 1.59* | 1.52* | 1.34* | 1.67* | 1.54* | 1.33* |
| [1.57, 1.62] | [1.49, 1.54] | [1.32, 1.37] | [1.64, 1.71] | [1.51, 1.57] | [1.30, 1.36] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.43 × 10−237 | <1.0 × 10−300 | <1.0 × 10−300 | 7.38 × 10−132 | |
| All-cause mortality | 1.17* | 1.12* | 1.05* | 1.39* | 1.28* | 1.19* |
| [1.16, 1.18] | [1.11, 1.14] | [1.03, 1.06] | [1.37, 1.41] | [1.27, 1.30] | [1.18, 1.21] | |
| 1.51 × 10−174 | 4.74 × 10−91 | 1.49 × 10−13 | <1.0 × 10−300 | 1.15 × 10–256 | 1.76 × 10−119 | |
| CVD mortality | 1.56* | 1.46* | 1.23* | 1.80* | 1.61* | 1.32* |
| [1.51, 1.61] | [1.42, 1.51] | [1.19, 1.27] | [1.73, 1.87] | [1.55, 1.68] | [1.26, 1.38] | |
| 5.19 × 10−176 | 2.38 × 10−127 | 3.38 × 10−34 | 1.09 × 10−199 | 2.17 × 10−121 | 1.74 × 10−37 | |
| Incident disease . | BMI (log) . | WHR . | ||||
|---|---|---|---|---|---|---|
| Model 1 . | Model 2 . | Model 3 . | Model 1 . | Model 2 . | Model 3 . | |
| Any CVD | 1.33* | 1.30* | 1.22* | 1.38* | 1.33* | 1.22* |
| [1.32, 1.34] | [1.29, 1.32] | [1.20, 1.23] | [1.37, 1.40] | [1.31, 1.34] | [1.20, 1.23] | |
| <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | <1.0 × 10−300 | 7.05 × 10−225 | |
| Ischaemic heart disease | 1.33* | 1.29* | 1.18* | 1.46* | 1.38* | 1.24* |
| [1.31, 1.34] | [1.27, 1.30] | [1.16, 1.19] | [1.44, 1.48] | [1.36, 1.40] | [1.22, 1.26] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 1.89 × 10−155 | <1.0 × 10−300 | <1.0 × 10−300 | 3.17 × 10−166 | |
| Atrial fibrillation | 1.36* | 1.35* | 1.27* | 1.30* | 1.27* | 1.18* |
| [1.35, 1.38] | [1.33, 1.37] | [1.25, 1.28] | [1.28, 1.32] | [1.25, 1.29] | [1.16, 1.20] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.11 × 10−281 | 8.66 × 10−239 | 2.85 × 10−190 | 1.04 × 10−80 | |
| Heart failure | 1.59* | 1.52* | 1.34* | 1.67* | 1.54* | 1.33* |
| [1.57, 1.62] | [1.49, 1.54] | [1.32, 1.37] | [1.64, 1.71] | [1.51, 1.57] | [1.30, 1.36] | |
| <1.0 × 10−300 | <1.0 × 10−300 | 3.43 × 10−237 | <1.0 × 10−300 | <1.0 × 10−300 | 7.38 × 10−132 | |
| All-cause mortality | 1.17* | 1.12* | 1.05* | 1.39* | 1.28* | 1.19* |
| [1.16, 1.18] | [1.11, 1.14] | [1.03, 1.06] | [1.37, 1.41] | [1.27, 1.30] | [1.18, 1.21] | |
| 1.51 × 10−174 | 4.74 × 10−91 | 1.49 × 10−13 | <1.0 × 10−300 | 1.15 × 10–256 | 1.76 × 10−119 | |
| CVD mortality | 1.56* | 1.46* | 1.23* | 1.80* | 1.61* | 1.32* |
| [1.51, 1.61] | [1.42, 1.51] | [1.19, 1.27] | [1.73, 1.87] | [1.55, 1.68] | [1.26, 1.38] | |
| 5.19 × 10−176 | 2.38 × 10−127 | 3.38 × 10−34 | 1.09 × 10−199 | 2.17 × 10−121 | 1.74 × 10−37 | |
Results are HRs associated with 1 SD increase in obesity [BMI (log) or WHR], 95% CIs, and P-values from Cox models relating the exposures to incident disease/events in the full sample. One SD BMI (log) = 4.4 kg/m2 and 1 SD WHR = 0.09.
*Represent significant associations.
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