Summary of randomized clinical trials investigating the effects of vitamin D supplementation on myocardial infarction
| Authors | Year | Intervention (patient number) | Outcome(s) | Results |
|---|---|---|---|---|
| Zittermann et al. EVITA trial150 | 2017 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
|  |
| Zittermann et al. EVITA trial143 | 2020 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial142 | 2018 | Cholecalciferol 4000 IU/die i.m for 3 years (83 HF patients and control group) |
| Vitamin D did not affect RAAS system: renin (r = 0.157) or aldosteronee (r= 0.048) |
| Zittermann et al. EVITA trial151 | 2019 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| Vitamin D did not improve myocardial function |
| Witte et al. VINDICATE study144 | 2016 | Cholecalciferol 4000 IU/die i.m. (n = 80 HF patients and control group) |
|  |
| Authors | Year | Intervention (patient number) | Outcome(s) | Results |
|---|---|---|---|---|
| Zittermann et al. EVITA trial150 | 2017 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial143 | 2020 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial142 | 2018 | Cholecalciferol 4000 IU/die i.m for 3 years (83 HF patients and control group) |
| Vitamin D did not affect RAAS system: renin (r = 0.157) or aldosteronee (r= 0.048) |
| Zittermann et al. EVITA trial151 | 2019 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| Vitamin D did not improve myocardial function |
| Witte et al. VINDICATE study144 | 2016 | Cholecalciferol 4000 IU/die i.m. (n = 80 HF patients and control group) |
| |
CI, confidence interval; OR, odds ratio; HF, heart failure; MCS, mechanical circulatory support; RAAS, renin–angiotensin–aldosterone system; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LVEF, left ventricular ejection fraction; 6MWT, 6-min walking test.
Summary of randomized clinical trials investigating the effects of vitamin D supplementation on myocardial infarction
| Authors | Year | Intervention (patient number) | Outcome(s) | Results |
|---|---|---|---|---|
| Zittermann et al. EVITA trial150 | 2017 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial143 | 2020 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial142 | 2018 | Cholecalciferol 4000 IU/die i.m for 3 years (83 HF patients and control group) |
| Vitamin D did not affect RAAS system: renin (r = 0.157) or aldosteronee (r= 0.048) |
| Zittermann et al. EVITA trial151 | 2019 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| Vitamin D did not improve myocardial function |
| Witte et al. VINDICATE study144 | 2016 | Cholecalciferol 4000 IU/die i.m. (n = 80 HF patients and control group) |
| |
| Authors | Year | Intervention (patient number) | Outcome(s) | Results |
|---|---|---|---|---|
| Zittermann et al. EVITA trial150 | 2017 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial143 | 2020 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| |
| Zittermann et al. EVITA trial142 | 2018 | Cholecalciferol 4000 IU/die i.m for 3 years (83 HF patients and control group) |
| Vitamin D did not affect RAAS system: renin (r = 0.157) or aldosteronee (r= 0.048) |
| Zittermann et al. EVITA trial151 | 2019 | Cholecalciferol 4000 IU/die i.m for 3 years (200 HF patients and control group) |
| Vitamin D did not improve myocardial function |
| Witte et al. VINDICATE study144 | 2016 | Cholecalciferol 4000 IU/die i.m. (n = 80 HF patients and control group) |
| |
CI, confidence interval; OR, odds ratio; HF, heart failure; MCS, mechanical circulatory support; RAAS, renin–angiotensin–aldosterone system; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; LVEF, left ventricular ejection fraction; 6MWT, 6-min walking test.
