Table 1. Open in new tab Maximum Plasma...

Table 1.

Maximum Plasma Concentration (1× C_max) of ARVs Used in This Study

Class	ARVs	In Vitro C_max(µM)^a	In Vivo C_max(mg/kg)^b
NRTI	ABC	4.47
	3TC	6.54
	FTC	7.28
	TDF	0.52
	TAF	0.47
NNRTI	EFV	12.9
	RPV	0.60
PI	LPV	15.59
	DRV	9.17
	RTV	1.23
InSTI	BIC	13.69	4.2
	CAB	9.74	5.0
	DTG	8.32	2.5
	RAL	6.53	66.7
	EVG	3.77
CYP3A	COBI	1.52

Class	ARVs	In Vitro C_max(µM)^a	In Vivo C_max(mg/kg)^b
NRTI	ABC	4.47
	3TC	6.54
	FTC	7.28
	TDF	0.52
	TAF	0.47
NNRTI	EFV	12.9
	RPV	0.60
PI	LPV	15.59
	DRV	9.17
	RTV	1.23
InSTI	BIC	13.69	4.2
	CAB	9.74	5.0
	DTG	8.32	2.5
	RAL	6.53	66.7
	EVG	3.77
CYP3A	COBI	1.52

Abbreviations: ABC, abacavir; ARVs, antiretrovirals; BIC, bictegravir; CAB, cabotegravir; COBI, cobicistat; DRV, darunavir; DTG, dolutegravir; EFV, efavirenz; EVG, elvitegravir; FTC, emtricitabine; InSTI, integrase strand transfer inhibitor; LPV, lopinavir; NNRTI, nonnucleoside reverse-transcriptase inhibitor; NRTI, nucleoside reverse-transcriptase inhibitor; PI, protease inhibitor; RAL, raltegravir; RPV, rilpivirine; RTV, ritonavir; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate; 3TC, lamivudine.

Values are obtained from the US Food and Drug Administration (https://www.accessdata.fda.gov).

Values selected to yield dam plasma levels equivalent to those reported in pregnant women, as determined in pilot studies.

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