Table 3 Open in new tab Estimated annual...

Baseline age interval	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P
18–45	9.03			0.0028		0.00020			0.0077		−1.55			0.216
45–50	−3.39	−12.42	4.47	0.0055	0.039	−0.00052	−0.00072	0.00018	5.6 × 10⁻⁵	0.0007	3.09	4.64	2.09	0.027	0.109
50–55	−0.47	2.91	5.08	0.567	0.765	−0.00056	−0.00004	0.00024	0.867	0.881	3.60	0.51	2.53	0.840	0.867
55–60	−6.50	−6.03	4.92	0.221	0.437	−0.00089	−0.00033	0.00023	0.157	0.354	6.87	3.27	2.41	0.176	0.382
60–65	−1.20	5.30	4.46	0.235	0.449	−0.00075	0.00014	0.00021	0.501	0.735	5.09	−1.78	2.16	0.408	0.659
65–70	−2.79	−1.59	4.33	0.714	0.849	−0.00118	−0.00044	0.00020	0.028	0.109	11.46	6.37	2.15	0.003	0.024
70–75	−6.35	−3.56	4.74	0.452	0.695	−0.00112	0.00006	0.00021	0.770	0.851	10.13	−1.33	2.45	0.587	0.765
75–104	−13.49	−7.14	7.90	0.366	0.623	−0.00100	0.00012	0.00036	0.744	0.849	12.11	1.99	4.09	0.627	0.790
	CSF pTau₁₈₁	PiB cortical mean SUVR	PiB precuneus SUVR
18–45	−0.08			0.500		−0.002			0.121		−2.8 × 10⁻³			0.072
45–50	0.36	0.44	0.22	0.041	0.129	0.005	0.007	0.0039	0.068	0.186	6.1 × 10⁻³	0.009	0.005	0.077	0.202
50–55	0.57	0.21	0.27	0.438	0.690	0.019	0.014	0.0054	0.012	0.063	0.02	0.015	0.007	0.030	0.110
55–60	1.22	0.65	0.28	0.019	0.085	0.030	0.011	0.0056	0.041	0.129	0.03	0.013	0.007	0.083	0.210
60–65	1.16	−0.06	0.26	0.808	0.867	0.039	0.009	0.0054	0.116	0.270	0.05	0.014	0.007	0.052	0.156
65–70	1.70	0.54	0.26	0.037	0.128	0.058	0.019	0.0050	0.00017	0.0017	0.07	0.017	0.006	0.007	0.043
70–75	1.39	−0.30	0.27	0.267	0.495	0.055	−0.003	0.0055	0.579	0.765	0.06	−0.001	0.007	0.831	0.867
75–104	1.78	0.38	0.44	0.391	0.648	0.051	−0.004	0.0067	0.595	0.765	0.06	−0.003	0.009	0.731	0.849
	MRI hippocampal volume	MRI cortical thickness	Cognitive composite
18–45	−2.91			0.673		−0.0117			3.8 × 10⁻⁸		0.0065			0.009
45–50	0.62	3.52	9.79	0.719	0.849	−0.0058	0.0060	0.0031	0.056	0.161	0.0019	−0.0046	0.0038	0.222	0.437
50–55	−13.79	−14.40	11.10	0.195	0.409	−0.0077	−0.0019	0.0035	0.580	0.765	−0.0034	−0.0053	0.0032	0.091	0.222
55–60	−43.09	−29.31	11.13	0.008	0.049	−0.0108	−0.0031	0.0034	0.359	0.623	−0.0022	0.0012	0.0019	0.521	0.746
60–65	−45.15	−2.06	9.29	0.824	0.867	−0.0111	−0.0004	0.0028	0.899	0.899	−0.0039	−0.0017	0.0018	0.362	0.623
65–70	−84.95	−39.80	7.97	5.9 × 10⁻⁷	0.00001	−0.0218	−0.0106	0.0024	8.6 × 10⁻⁶	0.0001	−0.0188	−0.0149	0.0018	2.0 × 10⁻¹⁷	1.3 × 10⁻¹⁵
70–75	−105.42	−20.47	8.27	0.013	0.065	−0.0209	0.0009	0.0025	0.716	0.849	−0.0244	−0.0056	0.0019	3.1 × 10⁻³	0.024
75–104	−98.66	6.77	9.76	0.488	0.732	−0.0218	−0.0009	0.0029	0.755	0.849	−0.0407	−0.0163	0.0021	1.9 × 10⁻¹⁵	6.0 × 10⁻¹⁴

Baseline age interval

Slope

Slope difference

Raw P

FDR P

Slope

Slope difference

Raw P

FDR P

Slope

Slope difference

Raw P

FDR P

CSF Aβ₄₂

CSF Aβ₄₂/Aβ₄₀

CSF Tau

18–45

9.03

0.0028

0.00020

0.0077

−1.55

0.216

45–50

−3.39

−12.42

4.47

0.0055

0.039

−0.00052

−0.00072

0.00018

5.6 × 10⁻⁵

0.0007

3.09

4.64

2.09

0.027

0.109

50–55

−0.47

2.91

5.08

0.567

0.765

−0.00056

−0.00004

0.00024

0.867

0.881

3.60

0.51

2.53

0.840

0.867

55–60

−6.50

−6.03

4.92

0.221

0.437

−0.00089

−0.00033

0.00023

0.157

0.354

6.87

3.27

2.41

0.176

0.382

60–65

−1.20

5.30

4.46

0.235

0.449

−0.00075

0.00014

0.00021

0.501

0.735

5.09

−1.78

2.16

0.408

0.659

65–70

−2.79

−1.59

4.33

0.714

0.849

−0.00118

−0.00044

0.00020

0.028

0.109

11.46

6.37

2.15

0.003

0.024

70–75

−6.35

−3.56

4.74

0.452

0.695

−0.00112

0.00006

0.00021

0.770

0.851

10.13

−1.33

2.45

0.587

0.765

75–104

−13.49

−7.14

7.90

0.366

0.623

−0.00100

0.00012

0.00036

0.744

0.849

12.11

1.99

4.09

0.627

0.790

CSF pTau₁₈₁

PiB cortical mean SUVR

PiB precuneus SUVR

18–45

−0.08

0.500

−0.002

0.121

−2.8 × 10⁻³

0.072

45–50

0.36

0.44

0.22

0.041

0.129

0.005

0.007

0.0039

0.068

0.186

6.1 × 10⁻³

0.009

0.005

0.077

0.202

50–55

0.57

0.21

0.27

0.438

0.690

0.019

0.014

0.0054

0.012

0.063

0.02

0.015

0.007

0.030

0.110

55–60

1.22

0.65

0.28

0.019

0.085

0.030

0.011

0.0056

0.041

0.129

0.03

0.013

0.007

0.083

0.210

60–65

1.16

−0.06

0.26

0.808

0.867

0.039

0.009

0.0054

0.116

0.270

0.05

0.014

0.007

0.052

0.156

65–70

1.70

0.54

0.26

0.037

0.128

0.058

0.019

0.0050

0.00017

0.0017

0.07

0.017

0.006

0.007

0.043

70–75

1.39

−0.30

0.27

0.267

0.495

0.055

−0.003

0.0055

0.579

0.765

0.06

−0.001

0.007

0.831

0.867

75–104

1.78

0.38

0.44

0.391

0.648

0.051

−0.004

0.0067

0.595

0.765

0.06

−0.003

0.009

0.731

0.849

MRI hippocampal volume

MRI cortical thickness

Cognitive composite

18–45

−2.91

0.673

−0.0117

3.8 × 10⁻⁸

0.0065

0.009

45–50

0.62

3.52

9.79

0.719

0.849

−0.0058

0.0060

0.0031

0.056

0.161

0.0019

−0.0046

0.0038

0.222

0.437

50–55

−13.79

−14.40

11.10

0.195

0.409

−0.0077

−0.0019

0.0035

0.580

0.765

−0.0034

−0.0053

0.0032

0.091

0.222

55–60

−43.09

−29.31

11.13

0.008

0.049

−0.0108

−0.0031

0.0034

0.359

0.623

−0.0022

0.0012

0.0019

0.521

0.746

60–65

−45.15

−2.06

9.29

0.824

0.867

−0.0111

−0.0004

0.0028

0.899

−0.0039

−0.0017

0.0018

0.362

0.623

65–70

−84.95

−39.80

7.97

5.9 × 10⁻⁷

0.00001

−0.0218

−0.0106

0.0024

8.6 × 10⁻⁶

0.0001

−0.0188

−0.0149

0.0018

2.0 × 10⁻¹⁷

1.3 × 10⁻¹⁵

70–75

−105.42

−20.47

8.27

0.013

0.065

−0.0209

0.0009

0.0025

0.716

0.849

−0.0244

−0.0056

0.0019

3.1 × 10⁻³

0.024

75–104

−98.66

6.77

9.76

0.488

0.732

−0.0218

−0.0009

0.0029

0.755

0.849

−0.0407

−0.0163

0.0021

1.9 × 10⁻¹⁵

6.0 × 10⁻¹⁴

Baseline age interval	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P
18–45	9.03			0.0028		0.00020			0.0077		−1.55			0.216
45–50	−3.39	−12.42	4.47	0.0055	0.039	−0.00052	−0.00072	0.00018	5.6 × 10⁻⁵	0.0007	3.09	4.64	2.09	0.027	0.109
50–55	−0.47	2.91	5.08	0.567	0.765	−0.00056	−0.00004	0.00024	0.867	0.881	3.60	0.51	2.53	0.840	0.867
55–60	−6.50	−6.03	4.92	0.221	0.437	−0.00089	−0.00033	0.00023	0.157	0.354	6.87	3.27	2.41	0.176	0.382
60–65	−1.20	5.30	4.46	0.235	0.449	−0.00075	0.00014	0.00021	0.501	0.735	5.09	−1.78	2.16	0.408	0.659
65–70	−2.79	−1.59	4.33	0.714	0.849	−0.00118	−0.00044	0.00020	0.028	0.109	11.46	6.37	2.15	0.003	0.024
70–75	−6.35	−3.56	4.74	0.452	0.695	−0.00112	0.00006	0.00021	0.770	0.851	10.13	−1.33	2.45	0.587	0.765
75–104	−13.49	−7.14	7.90	0.366	0.623	−0.00100	0.00012	0.00036	0.744	0.849	12.11	1.99	4.09	0.627	0.790
	CSF pTau₁₈₁	PiB cortical mean SUVR	PiB precuneus SUVR
18–45	−0.08			0.500		−0.002			0.121		−2.8 × 10⁻³			0.072
45–50	0.36	0.44	0.22	0.041	0.129	0.005	0.007	0.0039	0.068	0.186	6.1 × 10⁻³	0.009	0.005	0.077	0.202
50–55	0.57	0.21	0.27	0.438	0.690	0.019	0.014	0.0054	0.012	0.063	0.02	0.015	0.007	0.030	0.110
55–60	1.22	0.65	0.28	0.019	0.085	0.030	0.011	0.0056	0.041	0.129	0.03	0.013	0.007	0.083	0.210
60–65	1.16	−0.06	0.26	0.808	0.867	0.039	0.009	0.0054	0.116	0.270	0.05	0.014	0.007	0.052	0.156
65–70	1.70	0.54	0.26	0.037	0.128	0.058	0.019	0.0050	0.00017	0.0017	0.07	0.017	0.006	0.007	0.043
70–75	1.39	−0.30	0.27	0.267	0.495	0.055	−0.003	0.0055	0.579	0.765	0.06	−0.001	0.007	0.831	0.867
75–104	1.78	0.38	0.44	0.391	0.648	0.051	−0.004	0.0067	0.595	0.765	0.06	−0.003	0.009	0.731	0.849
	MRI hippocampal volume	MRI cortical thickness	Cognitive composite
18–45	−2.91			0.673		−0.0117			3.8 × 10⁻⁸		0.0065			0.009
45–50	0.62	3.52	9.79	0.719	0.849	−0.0058	0.0060	0.0031	0.056	0.161	0.0019	−0.0046	0.0038	0.222	0.437
50–55	−13.79	−14.40	11.10	0.195	0.409	−0.0077	−0.0019	0.0035	0.580	0.765	−0.0034	−0.0053	0.0032	0.091	0.222
55–60	−43.09	−29.31	11.13	0.008	0.049	−0.0108	−0.0031	0.0034	0.359	0.623	−0.0022	0.0012	0.0019	0.521	0.746
60–65	−45.15	−2.06	9.29	0.824	0.867	−0.0111	−0.0004	0.0028	0.899	0.899	−0.0039	−0.0017	0.0018	0.362	0.623
65–70	−84.95	−39.80	7.97	5.9 × 10⁻⁷	0.00001	−0.0218	−0.0106	0.0024	8.6 × 10⁻⁶	0.0001	−0.0188	−0.0149	0.0018	2.0 × 10⁻¹⁷	1.3 × 10⁻¹⁵
70–75	−105.42	−20.47	8.27	0.013	0.065	−0.0209	0.0009	0.0025	0.716	0.849	−0.0244	−0.0056	0.0019	3.1 × 10⁻³	0.024
75–104	−98.66	6.77	9.76	0.488	0.732	−0.0218	−0.0009	0.0029	0.755	0.849	−0.0407	−0.0163	0.0021	1.9 × 10⁻¹⁵	6.0 × 10⁻¹⁴

Baseline age interval

Slope

Slope difference

Raw P

FDR P

Slope

Slope difference

Raw P

FDR P

Slope

Slope difference

Raw P

FDR P

CSF Aβ₄₂

CSF Aβ₄₂/Aβ₄₀

CSF Tau

18–45

9.03

0.0028

0.00020

0.0077

−1.55

0.216

45–50

−3.39

−12.42

4.47

0.0055

0.039

−0.00052

−0.00072

0.00018

5.6 × 10⁻⁵

0.0007

3.09

4.64

2.09

0.027

0.109

50–55

−0.47

2.91

5.08

0.567

0.765

−0.00056

−0.00004

0.00024

0.867

0.881

3.60

0.51

2.53

0.840

0.867

55–60

−6.50

−6.03

4.92

0.221

0.437

−0.00089

−0.00033

0.00023

0.157

0.354

6.87

3.27

2.41

0.176

0.382

60–65

−1.20

5.30

4.46

0.235

0.449

−0.00075

0.00014

0.00021

0.501

0.735

5.09

−1.78

2.16

0.408

0.659

65–70

−2.79

−1.59

4.33

0.714

0.849

−0.00118

−0.00044

0.00020

0.028

0.109

11.46

6.37

2.15

0.003

0.024

70–75

−6.35

−3.56

4.74

0.452

0.695

−0.00112

0.00006

0.00021

0.770

0.851

10.13

−1.33

2.45

0.587

0.765

75–104

−13.49

−7.14

7.90

0.366

0.623

−0.00100

0.00012

0.00036

0.744

0.849

12.11

1.99

4.09

0.627

0.790

CSF pTau₁₈₁

PiB cortical mean SUVR

PiB precuneus SUVR

18–45

−0.08

0.500

−0.002

0.121

−2.8 × 10⁻³

0.072

45–50

0.36

0.44

0.22

0.041

0.129

0.005

0.007

0.0039

0.068

0.186

6.1 × 10⁻³

0.009

0.005

0.077

0.202

50–55

0.57

0.21

0.27

0.438

0.690

0.019

0.014

0.0054

0.012

0.063

0.02

0.015

0.007

0.030

0.110

55–60

1.22

0.65

0.28

0.019

0.085

0.030

0.011

0.0056

0.041

0.129

0.03

0.013

0.007

0.083

0.210

60–65

1.16

−0.06

0.26

0.808

0.867

0.039

0.009

0.0054

0.116

0.270

0.05

0.014

0.007

0.052

0.156

65–70

1.70

0.54

0.26

0.037

0.128

0.058

0.019

0.0050

0.00017

0.0017

0.07

0.017

0.006

0.007

0.043

70–75

1.39

−0.30

0.27

0.267

0.495

0.055

−0.003

0.0055

0.579

0.765

0.06

−0.001

0.007

0.831

0.867

75–104

1.78

0.38

0.44

0.391

0.648

0.051

−0.004

0.0067

0.595

0.765

0.06

−0.003

0.009

0.731

0.849

MRI hippocampal volume

MRI cortical thickness

Cognitive composite

18–45

−2.91

0.673

−0.0117

3.8 × 10⁻⁸

0.0065

0.009

45–50

0.62

3.52

9.79

0.719

0.849

−0.0058

0.0060

0.0031

0.056

0.161

0.0019

−0.0046

0.0038

0.222

0.437

50–55

−13.79

−14.40

11.10

0.195

0.409

−0.0077

−0.0019

0.0035

0.580

0.765

−0.0034

−0.0053

0.0032

0.091

0.222

55–60

−43.09

−29.31

11.13

0.008

0.049

−0.0108

−0.0031

0.0034

0.359

0.623

−0.0022

0.0012

0.0019

0.521

0.746

60–65

−45.15

−2.06

9.29

0.824

0.867

−0.0111

−0.0004

0.0028

0.899

−0.0039

−0.0017

0.0018

0.362

0.623

65–70

−84.95

−39.80

7.97

5.9 × 10⁻⁷

0.00001

−0.0218

−0.0106

0.0024

8.6 × 10⁻⁶

0.0001

−0.0188

−0.0149

0.0018

2.0 × 10⁻¹⁷

1.3 × 10⁻¹⁵

70–75

−105.42

−20.47

8.27

0.013

0.065

−0.0209

0.0009

0.0025

0.716

0.849

−0.0244

−0.0056

0.0019

3.1 × 10⁻³

0.024

75–104

−98.66

6.77

9.76

0.488

0.732

−0.0218

−0.0009

0.0029

0.755

0.849

−0.0407

−0.0163

0.0021

1.9 × 10⁻¹⁵

6.0 × 10⁻¹⁴

Table 3

Open in new tab

Estimated annual rates of longitudinal change by baseline age interval and consecutive slope difference from unadjusted analyses

Baseline age interval	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P
Baseline age interval	CSF Aβ₄₂					CSF Aβ₄₂/Aβ₄₀					CSF Tau
18–45	9.03			0.0028		0.00020			0.0077		−1.55			0.216
45–50	−3.39	−12.42	4.47	0.0055	0.039	−0.00052	−0.00072	0.00018	5.6 × 10⁻⁵	0.0007	3.09	4.64	2.09	0.027	0.109
50–55	−0.47	2.91	5.08	0.567	0.765	−0.00056	−0.00004	0.00024	0.867	0.881	3.60	0.51	2.53	0.840	0.867
55–60	−6.50	−6.03	4.92	0.221	0.437	−0.00089	−0.00033	0.00023	0.157	0.354	6.87	3.27	2.41	0.176	0.382
60–65	−1.20	5.30	4.46	0.235	0.449	−0.00075	0.00014	0.00021	0.501	0.735	5.09	−1.78	2.16	0.408	0.659
65–70	−2.79	−1.59	4.33	0.714	0.849	−0.00118	−0.00044	0.00020	0.028	0.109	11.46	6.37	2.15	0.003	0.024
70–75	−6.35	−3.56	4.74	0.452	0.695	−0.00112	0.00006	0.00021	0.770	0.851	10.13	−1.33	2.45	0.587	0.765
75–104	−13.49	−7.14	7.90	0.366	0.623	−0.00100	0.00012	0.00036	0.744	0.849	12.11	1.99	4.09	0.627	0.790
	CSF pTau₁₈₁					PiB cortical mean SUVR					PiB precuneus SUVR
18–45	−0.08			0.500		−0.002			0.121		−2.8 × 10⁻³			0.072
45–50	0.36	0.44	0.22	0.041	0.129	0.005	0.007	0.0039	0.068	0.186	6.1 × 10⁻³	0.009	0.005	0.077	0.202
50–55	0.57	0.21	0.27	0.438	0.690	0.019	0.014	0.0054	0.012	0.063	0.02	0.015	0.007	0.030	0.110
55–60	1.22	0.65	0.28	0.019	0.085	0.030	0.011	0.0056	0.041	0.129	0.03	0.013	0.007	0.083	0.210
60–65	1.16	−0.06	0.26	0.808	0.867	0.039	0.009	0.0054	0.116	0.270	0.05	0.014	0.007	0.052	0.156
65–70	1.70	0.54	0.26	0.037	0.128	0.058	0.019	0.0050	0.00017	0.0017	0.07	0.017	0.006	0.007	0.043
70–75	1.39	−0.30	0.27	0.267	0.495	0.055	−0.003	0.0055	0.579	0.765	0.06	−0.001	0.007	0.831	0.867
75–104	1.78	0.38	0.44	0.391	0.648	0.051	−0.004	0.0067	0.595	0.765	0.06	−0.003	0.009	0.731	0.849
	MRI hippocampal volume					MRI cortical thickness					Cognitive composite
18–45	−2.91			0.673		−0.0117			3.8 × 10⁻⁸		0.0065			0.009
45–50	0.62	3.52	9.79	0.719	0.849	−0.0058	0.0060	0.0031	0.056	0.161	0.0019	−0.0046	0.0038	0.222	0.437
50–55	−13.79	−14.40	11.10	0.195	0.409	−0.0077	−0.0019	0.0035	0.580	0.765	−0.0034	−0.0053	0.0032	0.091	0.222
55–60	−43.09	−29.31	11.13	0.008	0.049	−0.0108	−0.0031	0.0034	0.359	0.623	−0.0022	0.0012	0.0019	0.521	0.746
60–65	−45.15	−2.06	9.29	0.824	0.867	−0.0111	−0.0004	0.0028	0.899	0.899	−0.0039	−0.0017	0.0018	0.362	0.623
65–70	−84.95	−39.80	7.97	5.9 × 10⁻⁷	0.00001	−0.0218	−0.0106	0.0024	8.6 × 10⁻⁶	0.0001	−0.0188	−0.0149	0.0018	2.0 × 10⁻¹⁷	1.3 × 10⁻¹⁵
70–75	−105.42	−20.47	8.27	0.013	0.065	−0.0209	0.0009	0.0025	0.716	0.849	−0.0244	−0.0056	0.0019	3.1 × 10⁻³	0.024
75–104	−98.66	6.77	9.76	0.488	0.732	−0.0218	−0.0009	0.0029	0.755	0.849	−0.0407	−0.0163	0.0021	1.9 × 10⁻¹⁵	6.0 × 10⁻¹⁴

Baseline age interval	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P	Slope	Slope difference	SE	Raw P	FDR P
Baseline age interval	CSF Aβ₄₂					CSF Aβ₄₂/Aβ₄₀					CSF Tau
18–45	9.03			0.0028		0.00020			0.0077		−1.55			0.216
45–50	−3.39	−12.42	4.47	0.0055	0.039	−0.00052	−0.00072	0.00018	5.6 × 10⁻⁵	0.0007	3.09	4.64	2.09	0.027	0.109
50–55	−0.47	2.91	5.08	0.567	0.765	−0.00056	−0.00004	0.00024	0.867	0.881	3.60	0.51	2.53	0.840	0.867
55–60	−6.50	−6.03	4.92	0.221	0.437	−0.00089	−0.00033	0.00023	0.157	0.354	6.87	3.27	2.41	0.176	0.382
60–65	−1.20	5.30	4.46	0.235	0.449	−0.00075	0.00014	0.00021	0.501	0.735	5.09	−1.78	2.16	0.408	0.659
65–70	−2.79	−1.59	4.33	0.714	0.849	−0.00118	−0.00044	0.00020	0.028	0.109	11.46	6.37	2.15	0.003	0.024
70–75	−6.35	−3.56	4.74	0.452	0.695	−0.00112	0.00006	0.00021	0.770	0.851	10.13	−1.33	2.45	0.587	0.765
75–104	−13.49	−7.14	7.90	0.366	0.623	−0.00100	0.00012	0.00036	0.744	0.849	12.11	1.99	4.09	0.627	0.790
	CSF pTau₁₈₁					PiB cortical mean SUVR					PiB precuneus SUVR
18–45	−0.08			0.500		−0.002			0.121		−2.8 × 10⁻³			0.072
45–50	0.36	0.44	0.22	0.041	0.129	0.005	0.007	0.0039	0.068	0.186	6.1 × 10⁻³	0.009	0.005	0.077	0.202
50–55	0.57	0.21	0.27	0.438	0.690	0.019	0.014	0.0054	0.012	0.063	0.02	0.015	0.007	0.030	0.110
55–60	1.22	0.65	0.28	0.019	0.085	0.030	0.011	0.0056	0.041	0.129	0.03	0.013	0.007	0.083	0.210
60–65	1.16	−0.06	0.26	0.808	0.867	0.039	0.009	0.0054	0.116	0.270	0.05	0.014	0.007	0.052	0.156
65–70	1.70	0.54	0.26	0.037	0.128	0.058	0.019	0.0050	0.00017	0.0017	0.07	0.017	0.006	0.007	0.043
70–75	1.39	−0.30	0.27	0.267	0.495	0.055	−0.003	0.0055	0.579	0.765	0.06	−0.001	0.007	0.831	0.867
75–104	1.78	0.38	0.44	0.391	0.648	0.051	−0.004	0.0067	0.595	0.765	0.06	−0.003	0.009	0.731	0.849
	MRI hippocampal volume					MRI cortical thickness					Cognitive composite
18–45	−2.91			0.673		−0.0117			3.8 × 10⁻⁸		0.0065			0.009
45–50	0.62	3.52	9.79	0.719	0.849	−0.0058	0.0060	0.0031	0.056	0.161	0.0019	−0.0046	0.0038	0.222	0.437
50–55	−13.79	−14.40	11.10	0.195	0.409	−0.0077	−0.0019	0.0035	0.580	0.765	−0.0034	−0.0053	0.0032	0.091	0.222
55–60	−43.09	−29.31	11.13	0.008	0.049	−0.0108	−0.0031	0.0034	0.359	0.623	−0.0022	0.0012	0.0019	0.521	0.746
60–65	−45.15	−2.06	9.29	0.824	0.867	−0.0111	−0.0004	0.0028	0.899	0.899	−0.0039	−0.0017	0.0018	0.362	0.623
65–70	−84.95	−39.80	7.97	5.9 × 10⁻⁷	0.00001	−0.0218	−0.0106	0.0024	8.6 × 10⁻⁶	0.0001	−0.0188	−0.0149	0.0018	2.0 × 10⁻¹⁷	1.3 × 10⁻¹⁵
70–75	−105.42	−20.47	8.27	0.013	0.065	−0.0209	0.0009	0.0025	0.716	0.849	−0.0244	−0.0056	0.0019	3.1 × 10⁻³	0.024
75–104	−98.66	6.77	9.76	0.488	0.732	−0.0218	−0.0009	0.0029	0.755	0.849	−0.0407	−0.0163	0.0021	1.9 × 10⁻¹⁵	6.0 × 10⁻¹⁴

Estimated annual rates of longitudinal change (slope) as a function of baseline age intervals, and the slope differences between two adjacent baseline age intervals along with the associated SE, raw P-value (raw P) for testing whether each slope difference equals to 0 and FDR-corrected P-value (FDR P). The raw P-value on the first row tests whether the slope at the youngest baseline age interval equals 0. Raw P < 0.05 and FDR P < 0.05 are in bold. Slope difference = annual rate from the older age interval – annual rate from prior younger age interval. For example, slope difference at baseline age interval 50–55 equals the annual rate at 50–55 subtracting the annual rate at baseline age interval 45–50. SE = standard error to slope difference estimates.

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