Table 1 Open in new tab Cohort...

Variable	CSF cohort	PiB cohort	MRI cohort	Cognition cohort
Baseline age, years	475	61.44 (49.8–68.88)	519	64.11 (52.71–70.98)	873	66.7 (56.98–73)	2609	67.4 (60–74.18)
Education, years	475	16 (14–18)	485	16 (13–18)	837	16 (13–18)	2380	16 (12–18)
BMI	394	27.32 (24.02–30.7)	483	26.55 (23.7–29.89)	701	26.93 (23.83–30.36)	1392	26.64 (23.75–30.08)
Follow-up, years	475	5.94 (3.18–8.99)	519	4.92 (3–6.34)	873	4.65 (3–7.44)	2609	4.62 (3.09–9.22)
Gender	475		519		873		2609
Female		282 (59.37)		315 (60.69)		517 (59.22)		1595 (61.13)
Male		193 (40.63)		204 (39.31)		356 (40.78)		1014 (38.87)
Race	474		518		872		2607
Black		37 (7.81)		25 (4.83)		71 (8.14)		163 (6.25)
Other		5 (1.05)		6 (1.16)		9 (1.03)		12 (0.46)
White		432 (91.14)		487 (94.02)		792 (90.83)		2432 (93.29)
APOE genotype	470		513		863		2546
22		2 (0.43)		2 (0.39)		3 (0.35)		12 (0.47)
23		61 (12.98)		64 (12.48)		112 (12.98)		313 (12.29)
24		18 (3.83)		15 (2.92)		28 (3.24)		78 (3.06)
33		247 (52.55)		271 (52.83)		447 (51.8)		1416 (55.62)
34		123 (26.17)		146 (28.46)		242 (28.04)		636 (24.98)
44		19 (4.04)		15 (2.92)		31 (3.59)		91 (3.57)
APOE ɛ4	470		513		863		2546
Negative	475	310 (65.96)		337 (65.69)		562 (65.12)		1741 (68.38)
Positive		160 (34.04)		176 (34.31)		301 (34.88)		805 (31.62)
Education	475		485		837		2380
≤12 years		70 (14.74)		120 (24.74)		174 (20.79)		644 (27.06)
>12 years		405 (85.26)		365 (75.26)		663 (79.21)		1736 (72.94)
Family history	469		492		839		2368
No		108 (23.03)		168 (34.15)		289 (34.45)		1122 (47.38)
Yes		361 (76.97)		324 (65.85)		550 (65.55)		1246 (52.62)

Variable

CSF cohort

PiB cohort

MRI cohort

Cognition cohort

Valid n^a

Summary^b

Valid n^a

Summary^b

Valid n^a

Summary^b

Valid n^a

Summary^b

Baseline age, years

475

61.44 (49.8–68.88)

519

64.11 (52.71–70.98)

873

66.7 (56.98–73)

2609

67.4 (60–74.18)

Education, years

475

16 (14–18)

485

16 (13–18)

837

16 (13–18)

2380

16 (12–18)

BMI

394

27.32 (24.02–30.7)

483

26.55 (23.7–29.89)

701

26.93 (23.83–30.36)

1392

26.64 (23.75–30.08)

Follow-up, years

475

5.94 (3.18–8.99)

519

4.92 (3–6.34)

873

4.65 (3–7.44)

2609

4.62 (3.09–9.22)

Gender

475

519

873

2609

Female

282 (59.37)

315 (60.69)

517 (59.22)

1595 (61.13)

Male

193 (40.63)

204 (39.31)

356 (40.78)

1014 (38.87)

Race

474

518

872

2607

Black

37 (7.81)

25 (4.83)

71 (8.14)

163 (6.25)

Other

5 (1.05)

6 (1.16)

9 (1.03)

12 (0.46)

White

432 (91.14)

487 (94.02)

792 (90.83)

2432 (93.29)

APOE genotype

470

513

863

2546

2 (0.43)

2 (0.39)

3 (0.35)

12 (0.47)

61 (12.98)

64 (12.48)

112 (12.98)

313 (12.29)

18 (3.83)

15 (2.92)

28 (3.24)

78 (3.06)

247 (52.55)

271 (52.83)

447 (51.8)

1416 (55.62)

123 (26.17)

146 (28.46)

242 (28.04)

636 (24.98)

19 (4.04)

15 (2.92)

31 (3.59)

91 (3.57)

APOE ɛ4

470

513

863

2546

Negative

475

310 (65.96)

337 (65.69)

562 (65.12)

1741 (68.38)

Positive

160 (34.04)

176 (34.31)

301 (34.88)

805 (31.62)

Education

475

485

837

2380

≤12 years

70 (14.74)

120 (24.74)

174 (20.79)

644 (27.06)

>12 years

405 (85.26)

365 (75.26)

663 (79.21)

1736 (72.94)

Family history

469

492

839

2368

108 (23.03)

168 (34.15)

289 (34.45)

1122 (47.38)

Yes

361 (76.97)

324 (65.85)

550 (65.55)

1246 (52.62)

Variable	CSF cohort	PiB cohort	MRI cohort	Cognition cohort
Baseline age, years	475	61.44 (49.8–68.88)	519	64.11 (52.71–70.98)	873	66.7 (56.98–73)	2609	67.4 (60–74.18)
Education, years	475	16 (14–18)	485	16 (13–18)	837	16 (13–18)	2380	16 (12–18)
BMI	394	27.32 (24.02–30.7)	483	26.55 (23.7–29.89)	701	26.93 (23.83–30.36)	1392	26.64 (23.75–30.08)
Follow-up, years	475	5.94 (3.18–8.99)	519	4.92 (3–6.34)	873	4.65 (3–7.44)	2609	4.62 (3.09–9.22)
Gender	475		519		873		2609
Female		282 (59.37)		315 (60.69)		517 (59.22)		1595 (61.13)
Male		193 (40.63)		204 (39.31)		356 (40.78)		1014 (38.87)
Race	474		518		872		2607
Black		37 (7.81)		25 (4.83)		71 (8.14)		163 (6.25)
Other		5 (1.05)		6 (1.16)		9 (1.03)		12 (0.46)
White		432 (91.14)		487 (94.02)		792 (90.83)		2432 (93.29)
APOE genotype	470		513		863		2546
22		2 (0.43)		2 (0.39)		3 (0.35)		12 (0.47)
23		61 (12.98)		64 (12.48)		112 (12.98)		313 (12.29)
24		18 (3.83)		15 (2.92)		28 (3.24)		78 (3.06)
33		247 (52.55)		271 (52.83)		447 (51.8)		1416 (55.62)
34		123 (26.17)		146 (28.46)		242 (28.04)		636 (24.98)
44		19 (4.04)		15 (2.92)		31 (3.59)		91 (3.57)
APOE ɛ4	470		513		863		2546
Negative	475	310 (65.96)		337 (65.69)		562 (65.12)		1741 (68.38)
Positive		160 (34.04)		176 (34.31)		301 (34.88)		805 (31.62)
Education	475		485		837		2380
≤12 years		70 (14.74)		120 (24.74)		174 (20.79)		644 (27.06)
>12 years		405 (85.26)		365 (75.26)		663 (79.21)		1736 (72.94)
Family history	469		492		839		2368
No		108 (23.03)		168 (34.15)		289 (34.45)		1122 (47.38)
Yes		361 (76.97)		324 (65.85)		550 (65.55)		1246 (52.62)

Table 1

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Cohort characteristics as defined by modalities

Variable	CSF cohort		PiB cohort		MRI cohort		Cognition cohort
Variable	Valid n^a	Summary^b	Valid n^a	Summary^b	Valid n^a	Summary^b	Valid n^a	Summary^b
Baseline age, years	475	61.44 (49.8–68.88)	519	64.11 (52.71–70.98)	873	66.7 (56.98–73)	2609	67.4 (60–74.18)
Education, years	475	16 (14–18)	485	16 (13–18)	837	16 (13–18)	2380	16 (12–18)
BMI	394	27.32 (24.02–30.7)	483	26.55 (23.7–29.89)	701	26.93 (23.83–30.36)	1392	26.64 (23.75–30.08)
Follow-up, years	475	5.94 (3.18–8.99)	519	4.92 (3–6.34)	873	4.65 (3–7.44)	2609	4.62 (3.09–9.22)
Gender	475		519		873		2609
Female		282 (59.37)		315 (60.69)		517 (59.22)		1595 (61.13)
Male		193 (40.63)		204 (39.31)		356 (40.78)		1014 (38.87)
Race	474		518		872		2607
Black		37 (7.81)		25 (4.83)		71 (8.14)		163 (6.25)
Other		5 (1.05)		6 (1.16)		9 (1.03)		12 (0.46)
White		432 (91.14)		487 (94.02)		792 (90.83)		2432 (93.29)
APOE genotype	470		513		863		2546
22		2 (0.43)		2 (0.39)		3 (0.35)		12 (0.47)
23		61 (12.98)		64 (12.48)		112 (12.98)		313 (12.29)
24		18 (3.83)		15 (2.92)		28 (3.24)		78 (3.06)
33		247 (52.55)		271 (52.83)		447 (51.8)		1416 (55.62)
34		123 (26.17)		146 (28.46)		242 (28.04)		636 (24.98)
44		19 (4.04)		15 (2.92)		31 (3.59)		91 (3.57)
APOE ɛ4	470		513		863		2546
Negative	475	310 (65.96)		337 (65.69)		562 (65.12)		1741 (68.38)
Positive		160 (34.04)		176 (34.31)		301 (34.88)		805 (31.62)
Education	475		485		837		2380
≤12 years		70 (14.74)		120 (24.74)		174 (20.79)		644 (27.06)
>12 years		405 (85.26)		365 (75.26)		663 (79.21)		1736 (72.94)
Family history	469		492		839		2368
No		108 (23.03)		168 (34.15)		289 (34.45)		1122 (47.38)
Yes		361 (76.97)		324 (65.85)		550 (65.55)		1246 (52.62)

Variable	CSF cohort		PiB cohort		MRI cohort		Cognition cohort
Variable	Valid n^a	Summary^b	Valid n^a	Summary^b	Valid n^a	Summary^b	Valid n^a	Summary^b
Baseline age, years	475	61.44 (49.8–68.88)	519	64.11 (52.71–70.98)	873	66.7 (56.98–73)	2609	67.4 (60–74.18)
Education, years	475	16 (14–18)	485	16 (13–18)	837	16 (13–18)	2380	16 (12–18)
BMI	394	27.32 (24.02–30.7)	483	26.55 (23.7–29.89)	701	26.93 (23.83–30.36)	1392	26.64 (23.75–30.08)
Follow-up, years	475	5.94 (3.18–8.99)	519	4.92 (3–6.34)	873	4.65 (3–7.44)	2609	4.62 (3.09–9.22)
Gender	475		519		873		2609
Female		282 (59.37)		315 (60.69)		517 (59.22)		1595 (61.13)
Male		193 (40.63)		204 (39.31)		356 (40.78)		1014 (38.87)
Race	474		518		872		2607
Black		37 (7.81)		25 (4.83)		71 (8.14)		163 (6.25)
Other		5 (1.05)		6 (1.16)		9 (1.03)		12 (0.46)
White		432 (91.14)		487 (94.02)		792 (90.83)		2432 (93.29)
APOE genotype	470		513		863		2546
22		2 (0.43)		2 (0.39)		3 (0.35)		12 (0.47)
23		61 (12.98)		64 (12.48)		112 (12.98)		313 (12.29)
24		18 (3.83)		15 (2.92)		28 (3.24)		78 (3.06)
33		247 (52.55)		271 (52.83)		447 (51.8)		1416 (55.62)
34		123 (26.17)		146 (28.46)		242 (28.04)		636 (24.98)
44		19 (4.04)		15 (2.92)		31 (3.59)		91 (3.57)
APOE ɛ4	470		513		863		2546
Negative	475	310 (65.96)		337 (65.69)		562 (65.12)		1741 (68.38)
Positive		160 (34.04)		176 (34.31)		301 (34.88)		805 (31.62)
Education	475		485		837		2380
≤12 years		70 (14.74)		120 (24.74)		174 (20.79)		644 (27.06)
>12 years		405 (85.26)		365 (75.26)		663 (79.21)		1736 (72.94)
Family history	469		492		839		2368
No		108 (23.03)		168 (34.15)		289 (34.45)		1122 (47.38)
Yes		361 (76.97)		324 (65.85)		550 (65.55)		1246 (52.62)

Valid n represents the number of participants with no missing values for each modality marker under analysis.

Continuous characteristics are summarized as median and interquartile range (IQR: Q1–Q3); categorical characteristics are summarized as count (percentage).

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