Determinants of LA reservoir strain by univariable and multivariable linear regression analysis
. | Univariable . | Multivariable . | ||
---|---|---|---|---|
. | Sβ (95% CI) . | P-value . | Sβ (95% CI) . | P-value . |
Age, years | −0.16 (−0.29 to −0.02) | 0.022 | −0.02 (−0.13 to 0.08) | 0.650 |
Men | −0.10 (−2.75 to 0.47) | 0.164 | ||
Persistent AF | −0.64 (−7.60 to −5.43) | <0.001 | −0.30 (−4.17 to −1.91) | <0.001 |
Diabetes mellitus | −0.23 (−4.06 to −1.11) | 0.001 | −0.14 (−2.59 to −0.51) | 0.004 |
Hypertension | 0.03 (−1.14 to 1.68) | 0.704 | ||
Dyslipidaemia | 0.01 (−1.30 to 1.57) | 0.850 | ||
Current smoking | −0.08 (−3.64 to 0.89) | 0.232 | ||
Body mass index, kg/m2 | −0.06 (−0.59 to 0.24) | 0.284 | ||
Heart rate, beats/min | −0.27 (−0.30 to −0.10) | <0.001 | −0.11 (−0.16 to −0.01) | 0.026 |
eGFR, mL/min/1.73 m2 | 0.25 (0.08 to 0.27) | <0.001 | 0.07 (−0.03 to 0.12) | 0.196 |
Log (CRP), mg/dL | −0.03 (−3.87 to 2.43) | 0.679 | ||
Log (BNP), pg/mL | −0.64 (−15.37 to −11.04) | <0.001 | −0.19 (−6.59 to −1.32) | 0.004 |
Log (IL-6), pg/mL | −0.16 (−9.72 to −0.85) | 0.020 | 0.06 (−1.50 to 5.38) | 0.268 |
Log (ICTP), ng/mL | −0.22 (−23.53 to −5.34) | 0.002 | −0.04 (−9.59 to 4.71) | 0.501 |
LV mass index, g/m2 | −0.25 (−0.20 to −0.06) | <0.001 | 0.03 (−0.03 to 0.07) | 0.485 |
LV ejection fraction, % | 0.49 (0.38–0.62) | <0.001 | 0.17 (0.07–0.28) | 0.002 |
LA volume index, mL/m2 | −0.59 (−0.55 to −0.37) | <0.001 | −0.31 (−0.33 to −0.15) | <0.001 |
E/e′ ratio | −0.20 (−1.26 to −0.25) | 0.003 | 0.06 (−0.16 to 0.60) | 0.265 |
. | Univariable . | Multivariable . | ||
---|---|---|---|---|
. | Sβ (95% CI) . | P-value . | Sβ (95% CI) . | P-value . |
Age, years | −0.16 (−0.29 to −0.02) | 0.022 | −0.02 (−0.13 to 0.08) | 0.650 |
Men | −0.10 (−2.75 to 0.47) | 0.164 | ||
Persistent AF | −0.64 (−7.60 to −5.43) | <0.001 | −0.30 (−4.17 to −1.91) | <0.001 |
Diabetes mellitus | −0.23 (−4.06 to −1.11) | 0.001 | −0.14 (−2.59 to −0.51) | 0.004 |
Hypertension | 0.03 (−1.14 to 1.68) | 0.704 | ||
Dyslipidaemia | 0.01 (−1.30 to 1.57) | 0.850 | ||
Current smoking | −0.08 (−3.64 to 0.89) | 0.232 | ||
Body mass index, kg/m2 | −0.06 (−0.59 to 0.24) | 0.284 | ||
Heart rate, beats/min | −0.27 (−0.30 to −0.10) | <0.001 | −0.11 (−0.16 to −0.01) | 0.026 |
eGFR, mL/min/1.73 m2 | 0.25 (0.08 to 0.27) | <0.001 | 0.07 (−0.03 to 0.12) | 0.196 |
Log (CRP), mg/dL | −0.03 (−3.87 to 2.43) | 0.679 | ||
Log (BNP), pg/mL | −0.64 (−15.37 to −11.04) | <0.001 | −0.19 (−6.59 to −1.32) | 0.004 |
Log (IL-6), pg/mL | −0.16 (−9.72 to −0.85) | 0.020 | 0.06 (−1.50 to 5.38) | 0.268 |
Log (ICTP), ng/mL | −0.22 (−23.53 to −5.34) | 0.002 | −0.04 (−9.59 to 4.71) | 0.501 |
LV mass index, g/m2 | −0.25 (−0.20 to −0.06) | <0.001 | 0.03 (−0.03 to 0.07) | 0.485 |
LV ejection fraction, % | 0.49 (0.38–0.62) | <0.001 | 0.17 (0.07–0.28) | 0.002 |
LA volume index, mL/m2 | −0.59 (−0.55 to −0.37) | <0.001 | −0.31 (−0.33 to −0.15) | <0.001 |
E/e′ ratio | −0.20 (−1.26 to −0.25) | 0.003 | 0.06 (−0.16 to 0.60) | 0.265 |
AF, atrial fibrillation; BNP, B-type natriuretic peptide; CI, confidence interval; CRP, C-reactive protein; E, early diastolic transmitral flow velocity; e′, early diastolic mitral annular velocity; eGFR, estimated glomerular filtration rate; ICTP, carboxy-terminal telopeptide of procollagen Type I; IL-6, Interleukin-6; LA, left atrium; LV, left ventricle; Sβ, standardized β.
Determinants of LA reservoir strain by univariable and multivariable linear regression analysis
. | Univariable . | Multivariable . | ||
---|---|---|---|---|
. | Sβ (95% CI) . | P-value . | Sβ (95% CI) . | P-value . |
Age, years | −0.16 (−0.29 to −0.02) | 0.022 | −0.02 (−0.13 to 0.08) | 0.650 |
Men | −0.10 (−2.75 to 0.47) | 0.164 | ||
Persistent AF | −0.64 (−7.60 to −5.43) | <0.001 | −0.30 (−4.17 to −1.91) | <0.001 |
Diabetes mellitus | −0.23 (−4.06 to −1.11) | 0.001 | −0.14 (−2.59 to −0.51) | 0.004 |
Hypertension | 0.03 (−1.14 to 1.68) | 0.704 | ||
Dyslipidaemia | 0.01 (−1.30 to 1.57) | 0.850 | ||
Current smoking | −0.08 (−3.64 to 0.89) | 0.232 | ||
Body mass index, kg/m2 | −0.06 (−0.59 to 0.24) | 0.284 | ||
Heart rate, beats/min | −0.27 (−0.30 to −0.10) | <0.001 | −0.11 (−0.16 to −0.01) | 0.026 |
eGFR, mL/min/1.73 m2 | 0.25 (0.08 to 0.27) | <0.001 | 0.07 (−0.03 to 0.12) | 0.196 |
Log (CRP), mg/dL | −0.03 (−3.87 to 2.43) | 0.679 | ||
Log (BNP), pg/mL | −0.64 (−15.37 to −11.04) | <0.001 | −0.19 (−6.59 to −1.32) | 0.004 |
Log (IL-6), pg/mL | −0.16 (−9.72 to −0.85) | 0.020 | 0.06 (−1.50 to 5.38) | 0.268 |
Log (ICTP), ng/mL | −0.22 (−23.53 to −5.34) | 0.002 | −0.04 (−9.59 to 4.71) | 0.501 |
LV mass index, g/m2 | −0.25 (−0.20 to −0.06) | <0.001 | 0.03 (−0.03 to 0.07) | 0.485 |
LV ejection fraction, % | 0.49 (0.38–0.62) | <0.001 | 0.17 (0.07–0.28) | 0.002 |
LA volume index, mL/m2 | −0.59 (−0.55 to −0.37) | <0.001 | −0.31 (−0.33 to −0.15) | <0.001 |
E/e′ ratio | −0.20 (−1.26 to −0.25) | 0.003 | 0.06 (−0.16 to 0.60) | 0.265 |
. | Univariable . | Multivariable . | ||
---|---|---|---|---|
. | Sβ (95% CI) . | P-value . | Sβ (95% CI) . | P-value . |
Age, years | −0.16 (−0.29 to −0.02) | 0.022 | −0.02 (−0.13 to 0.08) | 0.650 |
Men | −0.10 (−2.75 to 0.47) | 0.164 | ||
Persistent AF | −0.64 (−7.60 to −5.43) | <0.001 | −0.30 (−4.17 to −1.91) | <0.001 |
Diabetes mellitus | −0.23 (−4.06 to −1.11) | 0.001 | −0.14 (−2.59 to −0.51) | 0.004 |
Hypertension | 0.03 (−1.14 to 1.68) | 0.704 | ||
Dyslipidaemia | 0.01 (−1.30 to 1.57) | 0.850 | ||
Current smoking | −0.08 (−3.64 to 0.89) | 0.232 | ||
Body mass index, kg/m2 | −0.06 (−0.59 to 0.24) | 0.284 | ||
Heart rate, beats/min | −0.27 (−0.30 to −0.10) | <0.001 | −0.11 (−0.16 to −0.01) | 0.026 |
eGFR, mL/min/1.73 m2 | 0.25 (0.08 to 0.27) | <0.001 | 0.07 (−0.03 to 0.12) | 0.196 |
Log (CRP), mg/dL | −0.03 (−3.87 to 2.43) | 0.679 | ||
Log (BNP), pg/mL | −0.64 (−15.37 to −11.04) | <0.001 | −0.19 (−6.59 to −1.32) | 0.004 |
Log (IL-6), pg/mL | −0.16 (−9.72 to −0.85) | 0.020 | 0.06 (−1.50 to 5.38) | 0.268 |
Log (ICTP), ng/mL | −0.22 (−23.53 to −5.34) | 0.002 | −0.04 (−9.59 to 4.71) | 0.501 |
LV mass index, g/m2 | −0.25 (−0.20 to −0.06) | <0.001 | 0.03 (−0.03 to 0.07) | 0.485 |
LV ejection fraction, % | 0.49 (0.38–0.62) | <0.001 | 0.17 (0.07–0.28) | 0.002 |
LA volume index, mL/m2 | −0.59 (−0.55 to −0.37) | <0.001 | −0.31 (−0.33 to −0.15) | <0.001 |
E/e′ ratio | −0.20 (−1.26 to −0.25) | 0.003 | 0.06 (−0.16 to 0.60) | 0.265 |
AF, atrial fibrillation; BNP, B-type natriuretic peptide; CI, confidence interval; CRP, C-reactive protein; E, early diastolic transmitral flow velocity; e′, early diastolic mitral annular velocity; eGFR, estimated glomerular filtration rate; ICTP, carboxy-terminal telopeptide of procollagen Type I; IL-6, Interleukin-6; LA, left atrium; LV, left ventricle; Sβ, standardized β.
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