Table 2

Determinants of LA reservoir strain by univariable and multivariable linear regression analysis

UnivariableMultivariable
Sβ (95% CI)P-valueSβ (95% CI)P-value
Age, years−0.16 (−0.29 to −0.02)0.022−0.02 (−0.13 to 0.08)0.650
Men−0.10 (−2.75 to 0.47)0.164
Persistent AF−0.64 (−7.60 to −5.43)<0.001−0.30 (−4.17 to −1.91)<0.001
Diabetes mellitus−0.23 (−4.06 to −1.11)0.001−0.14 (−2.59 to −0.51)0.004
Hypertension0.03 (−1.14 to 1.68)0.704
Dyslipidaemia0.01 (−1.30 to 1.57)0.850
Current smoking−0.08 (−3.64 to 0.89)0.232
Body mass index, kg/m2−0.06 (−0.59 to 0.24)0.284
Heart rate, beats/min−0.27 (−0.30 to −0.10)<0.001−0.11 (−0.16 to −0.01)0.026
eGFR, mL/min/1.73 m20.25 (0.08 to 0.27)<0.0010.07 (−0.03 to 0.12)0.196
Log (CRP), mg/dL−0.03 (−3.87 to 2.43)0.679
Log (BNP), pg/mL−0.64 (−15.37 to −11.04)<0.001−0.19 (−6.59 to −1.32)0.004
Log (IL-6), pg/mL−0.16 (−9.72 to −0.85)0.0200.06 (−1.50 to 5.38)0.268
Log (ICTP), ng/mL−0.22 (−23.53 to −5.34)0.002−0.04 (−9.59 to 4.71)0.501
LV mass index, g/m2−0.25 (−0.20 to −0.06)<0.0010.03 (−0.03 to 0.07)0.485
LV ejection fraction, %0.49 (0.38–0.62)<0.0010.17 (0.07–0.28)0.002
LA volume index, mL/m2−0.59 (−0.55 to −0.37)<0.001−0.31 (−0.33 to −0.15)<0.001
E/e′ ratio−0.20 (−1.26 to −0.25)0.0030.06 (−0.16 to 0.60)0.265
UnivariableMultivariable
Sβ (95% CI)P-valueSβ (95% CI)P-value
Age, years−0.16 (−0.29 to −0.02)0.022−0.02 (−0.13 to 0.08)0.650
Men−0.10 (−2.75 to 0.47)0.164
Persistent AF−0.64 (−7.60 to −5.43)<0.001−0.30 (−4.17 to −1.91)<0.001
Diabetes mellitus−0.23 (−4.06 to −1.11)0.001−0.14 (−2.59 to −0.51)0.004
Hypertension0.03 (−1.14 to 1.68)0.704
Dyslipidaemia0.01 (−1.30 to 1.57)0.850
Current smoking−0.08 (−3.64 to 0.89)0.232
Body mass index, kg/m2−0.06 (−0.59 to 0.24)0.284
Heart rate, beats/min−0.27 (−0.30 to −0.10)<0.001−0.11 (−0.16 to −0.01)0.026
eGFR, mL/min/1.73 m20.25 (0.08 to 0.27)<0.0010.07 (−0.03 to 0.12)0.196
Log (CRP), mg/dL−0.03 (−3.87 to 2.43)0.679
Log (BNP), pg/mL−0.64 (−15.37 to −11.04)<0.001−0.19 (−6.59 to −1.32)0.004
Log (IL-6), pg/mL−0.16 (−9.72 to −0.85)0.0200.06 (−1.50 to 5.38)0.268
Log (ICTP), ng/mL−0.22 (−23.53 to −5.34)0.002−0.04 (−9.59 to 4.71)0.501
LV mass index, g/m2−0.25 (−0.20 to −0.06)<0.0010.03 (−0.03 to 0.07)0.485
LV ejection fraction, %0.49 (0.38–0.62)<0.0010.17 (0.07–0.28)0.002
LA volume index, mL/m2−0.59 (−0.55 to −0.37)<0.001−0.31 (−0.33 to −0.15)<0.001
E/e′ ratio−0.20 (−1.26 to −0.25)0.0030.06 (−0.16 to 0.60)0.265

AF, atrial fibrillation; BNP, B-type natriuretic peptide; CI, confidence interval; CRP, C-reactive protein; E, early diastolic transmitral flow velocity; e′, early diastolic mitral annular velocity; eGFR, estimated glomerular filtration rate; ICTP, carboxy-terminal telopeptide of procollagen Type I; IL-6, Interleukin-6; LA, left atrium; LV, left ventricle; Sβ, standardized β.

Table 2

Determinants of LA reservoir strain by univariable and multivariable linear regression analysis

UnivariableMultivariable
Sβ (95% CI)P-valueSβ (95% CI)P-value
Age, years−0.16 (−0.29 to −0.02)0.022−0.02 (−0.13 to 0.08)0.650
Men−0.10 (−2.75 to 0.47)0.164
Persistent AF−0.64 (−7.60 to −5.43)<0.001−0.30 (−4.17 to −1.91)<0.001
Diabetes mellitus−0.23 (−4.06 to −1.11)0.001−0.14 (−2.59 to −0.51)0.004
Hypertension0.03 (−1.14 to 1.68)0.704
Dyslipidaemia0.01 (−1.30 to 1.57)0.850
Current smoking−0.08 (−3.64 to 0.89)0.232
Body mass index, kg/m2−0.06 (−0.59 to 0.24)0.284
Heart rate, beats/min−0.27 (−0.30 to −0.10)<0.001−0.11 (−0.16 to −0.01)0.026
eGFR, mL/min/1.73 m20.25 (0.08 to 0.27)<0.0010.07 (−0.03 to 0.12)0.196
Log (CRP), mg/dL−0.03 (−3.87 to 2.43)0.679
Log (BNP), pg/mL−0.64 (−15.37 to −11.04)<0.001−0.19 (−6.59 to −1.32)0.004
Log (IL-6), pg/mL−0.16 (−9.72 to −0.85)0.0200.06 (−1.50 to 5.38)0.268
Log (ICTP), ng/mL−0.22 (−23.53 to −5.34)0.002−0.04 (−9.59 to 4.71)0.501
LV mass index, g/m2−0.25 (−0.20 to −0.06)<0.0010.03 (−0.03 to 0.07)0.485
LV ejection fraction, %0.49 (0.38–0.62)<0.0010.17 (0.07–0.28)0.002
LA volume index, mL/m2−0.59 (−0.55 to −0.37)<0.001−0.31 (−0.33 to −0.15)<0.001
E/e′ ratio−0.20 (−1.26 to −0.25)0.0030.06 (−0.16 to 0.60)0.265
UnivariableMultivariable
Sβ (95% CI)P-valueSβ (95% CI)P-value
Age, years−0.16 (−0.29 to −0.02)0.022−0.02 (−0.13 to 0.08)0.650
Men−0.10 (−2.75 to 0.47)0.164
Persistent AF−0.64 (−7.60 to −5.43)<0.001−0.30 (−4.17 to −1.91)<0.001
Diabetes mellitus−0.23 (−4.06 to −1.11)0.001−0.14 (−2.59 to −0.51)0.004
Hypertension0.03 (−1.14 to 1.68)0.704
Dyslipidaemia0.01 (−1.30 to 1.57)0.850
Current smoking−0.08 (−3.64 to 0.89)0.232
Body mass index, kg/m2−0.06 (−0.59 to 0.24)0.284
Heart rate, beats/min−0.27 (−0.30 to −0.10)<0.001−0.11 (−0.16 to −0.01)0.026
eGFR, mL/min/1.73 m20.25 (0.08 to 0.27)<0.0010.07 (−0.03 to 0.12)0.196
Log (CRP), mg/dL−0.03 (−3.87 to 2.43)0.679
Log (BNP), pg/mL−0.64 (−15.37 to −11.04)<0.001−0.19 (−6.59 to −1.32)0.004
Log (IL-6), pg/mL−0.16 (−9.72 to −0.85)0.0200.06 (−1.50 to 5.38)0.268
Log (ICTP), ng/mL−0.22 (−23.53 to −5.34)0.002−0.04 (−9.59 to 4.71)0.501
LV mass index, g/m2−0.25 (−0.20 to −0.06)<0.0010.03 (−0.03 to 0.07)0.485
LV ejection fraction, %0.49 (0.38–0.62)<0.0010.17 (0.07–0.28)0.002
LA volume index, mL/m2−0.59 (−0.55 to −0.37)<0.001−0.31 (−0.33 to −0.15)<0.001
E/e′ ratio−0.20 (−1.26 to −0.25)0.0030.06 (−0.16 to 0.60)0.265

AF, atrial fibrillation; BNP, B-type natriuretic peptide; CI, confidence interval; CRP, C-reactive protein; E, early diastolic transmitral flow velocity; e′, early diastolic mitral annular velocity; eGFR, estimated glomerular filtration rate; ICTP, carboxy-terminal telopeptide of procollagen Type I; IL-6, Interleukin-6; LA, left atrium; LV, left ventricle; Sβ, standardized β.

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