| . | Total (n = 2377) . | HCMR− (n = 1320) . | oHCMR+ (n = 438) . | HCMR-S− (n = 565) . | oHCMR-S+ (n = 273) . |
|---|---|---|---|---|---|
| Mean LVWT, mm | 8.5 (7.4–10.0) | 8.7 (7.4–10.0) | 8.8 (7.5–9.9) | 8.7 (7.3–10.1) | 8.9 (7.5–10.3) |
| Max LVWT, mm | 16.9 (14.2–20.3) | 17.5 (14.4–20.7) | 17.5 (14.6–20.1) | 17.4 (14.2–20.8) | 17.8 (14.7–20.7) |
| LVEDV, mL | 169.1 (143.8–195.3) | 167.3 (141.6–196.9) | 175.1 ± 42.5* | 169.3 ± 39.9 | 176.5 ± 42.5** |
| LVEDVI, mL/m2 | 84.2 (73.8–94.2) | 83.3 (73.1–93.7) | 86.4 (75.8–96.3)* | 83.3 (48.9–93.4) | 86.9 ± 16.7 |
| LVESV, mL | 60.9 (44.7–75.9) | 59.7 (44.6–74.1) | 62.9 (44.8–78.5) | 59.3 (44.5–74.1) | 59.9 (45.0–74.1) |
| LVESVI, mL/m2 | 30.1 (22.9–36.7) | 29.8 (22.7–36.2) | 30.9 (23.4–37.7) | 29.7 (23.0–36.0) | 28.9 (21.9–35.8) |
| LVSV, mL | 107.2 (94.3–121.9) | 106.3 (93.3–121.2) | 110.3 (96.0–125.0)* | 105.3 (93.4–119.0) | 111.9 ± 25.3** |
| LVSVI, mL/m2 | 53.7 (47.5–60.1) | 53.2 (47.2–59.9) | 55.0 (48.2–61.6)* | 53.2 (47.3–59.8) | 53.7 (47.1–60.9) |
| LVEF, % | 64.6 (59.2–70.2) | 64.7 (59.5–70.0) | 64.5 (58.8–70.5) | 64.6 (59.3–69.8) | 65.7 (60.7–71.4) |
| LVM, g | 165.1 (128.8–199.3) | 159.0 (125.6–190.4) | 171.7 ± 58.6* | 156.9 (125.2–183.7) | 198.0 ± 70.2** |
| LVMI, g/m2 | 81.6 (65.5–96.7) | 78.9 (64.3–92.4) | 94.4 (74.3–115.3)* | 78.3 (63.9–91.3) | 97.1 ± 30.0** |
| LGE | 1169 (50) | 627 (48) | 208 (48) | 673 (52) | 190 (44) |
| LVOT drop rest, mmHg | 7.9 (3.0–12.0) | 64.1 (42.1–82.8)* | 5.6 (0.0–8.0) | 15.3 (9.9–21.0)** | |
| LVOT drop stress, mmHg | 8.6 (2.0–14.0) | 64.2 (42.0–85.0)** | |||
| . | Total (n = 2377) . | HCMR− (n = 1320) . | oHCMR+ (n = 438) . | HCMR-S− (n = 565) . | oHCMR-S+ (n = 273) . |
|---|---|---|---|---|---|
| Mean LVWT, mm | 8.5 (7.4–10.0) | 8.7 (7.4–10.0) | 8.8 (7.5–9.9) | 8.7 (7.3–10.1) | 8.9 (7.5–10.3) |
| Max LVWT, mm | 16.9 (14.2–20.3) | 17.5 (14.4–20.7) | 17.5 (14.6–20.1) | 17.4 (14.2–20.8) | 17.8 (14.7–20.7) |
| LVEDV, mL | 169.1 (143.8–195.3) | 167.3 (141.6–196.9) | 175.1 ± 42.5* | 169.3 ± 39.9 | 176.5 ± 42.5** |
| LVEDVI, mL/m2 | 84.2 (73.8–94.2) | 83.3 (73.1–93.7) | 86.4 (75.8–96.3)* | 83.3 (48.9–93.4) | 86.9 ± 16.7 |
| LVESV, mL | 60.9 (44.7–75.9) | 59.7 (44.6–74.1) | 62.9 (44.8–78.5) | 59.3 (44.5–74.1) | 59.9 (45.0–74.1) |
| LVESVI, mL/m2 | 30.1 (22.9–36.7) | 29.8 (22.7–36.2) | 30.9 (23.4–37.7) | 29.7 (23.0–36.0) | 28.9 (21.9–35.8) |
| LVSV, mL | 107.2 (94.3–121.9) | 106.3 (93.3–121.2) | 110.3 (96.0–125.0)* | 105.3 (93.4–119.0) | 111.9 ± 25.3** |
| LVSVI, mL/m2 | 53.7 (47.5–60.1) | 53.2 (47.2–59.9) | 55.0 (48.2–61.6)* | 53.2 (47.3–59.8) | 53.7 (47.1–60.9) |
| LVEF, % | 64.6 (59.2–70.2) | 64.7 (59.5–70.0) | 64.5 (58.8–70.5) | 64.6 (59.3–69.8) | 65.7 (60.7–71.4) |
| LVM, g | 165.1 (128.8–199.3) | 159.0 (125.6–190.4) | 171.7 ± 58.6* | 156.9 (125.2–183.7) | 198.0 ± 70.2** |
| LVMI, g/m2 | 81.6 (65.5–96.7) | 78.9 (64.3–92.4) | 94.4 (74.3–115.3)* | 78.3 (63.9–91.3) | 97.1 ± 30.0** |
| LGE | 1169 (50) | 627 (48) | 208 (48) | 673 (52) | 190 (44) |
| LVOT drop rest, mmHg | 7.9 (3.0–12.0) | 64.1 (42.1–82.8)* | 5.6 (0.0–8.0) | 15.3 (9.9–21.0)** | |
| LVOT drop stress, mmHg | 8.6 (2.0–14.0) | 64.2 (42.0–85.0)** | |||
Values are given as mean ± SD or median (25–75% percentiles) or n (% with respect to number of valid cases).
HCM, hypertrophic cardiomyopathy; HCMR-, HCM non-obstructive cases at rest; HCMR-S−, HCM non-obstructive cases at rest and stress; LVWT, left ventricular wall thickness; LVEDV, left ventricular end-diastolic volume; LVEDVI, left ventricular end-diastolic volume indexed; LVESV, left ventricular end-systolic volume; LVESVI, left ventricular end-systolic volume indexed; LVSV, left ventricular stroke volume; LVSVI, left ventricular stroke volume indexed; LVEF, left ventricular ejection fraction; LVM, left ventricular mass; LVMI, left ventricular mass index; LGE, presence of late gadolinium enhancement; LVOT, left ventricular outflow tract; oHCM, obstructive hypertrophic cardiomyopathy; oHCMR+, HCM obstructive cases at rest; oHCMR-S+, HCM obstructive cases at stress but not at rest. Mean and Max LVWT measures derived from the personalized 3D meshes. The rest of imaging characteristics were derived from CMR images.
P < 0.05 with respect to Group R−.
P < 0.05 with respect to Group R−S−. For more details, including the number of valid cases for each variable, see Supplementary materials. From the total number of cases in the HCMR cohort, only those used for discriminant analysis are reported.
| . | Total (n = 2377) . | HCMR− (n = 1320) . | oHCMR+ (n = 438) . | HCMR-S− (n = 565) . | oHCMR-S+ (n = 273) . |
|---|---|---|---|---|---|
| Mean LVWT, mm | 8.5 (7.4–10.0) | 8.7 (7.4–10.0) | 8.8 (7.5–9.9) | 8.7 (7.3–10.1) | 8.9 (7.5–10.3) |
| Max LVWT, mm | 16.9 (14.2–20.3) | 17.5 (14.4–20.7) | 17.5 (14.6–20.1) | 17.4 (14.2–20.8) | 17.8 (14.7–20.7) |
| LVEDV, mL | 169.1 (143.8–195.3) | 167.3 (141.6–196.9) | 175.1 ± 42.5* | 169.3 ± 39.9 | 176.5 ± 42.5** |
| LVEDVI, mL/m2 | 84.2 (73.8–94.2) | 83.3 (73.1–93.7) | 86.4 (75.8–96.3)* | 83.3 (48.9–93.4) | 86.9 ± 16.7 |
| LVESV, mL | 60.9 (44.7–75.9) | 59.7 (44.6–74.1) | 62.9 (44.8–78.5) | 59.3 (44.5–74.1) | 59.9 (45.0–74.1) |
| LVESVI, mL/m2 | 30.1 (22.9–36.7) | 29.8 (22.7–36.2) | 30.9 (23.4–37.7) | 29.7 (23.0–36.0) | 28.9 (21.9–35.8) |
| LVSV, mL | 107.2 (94.3–121.9) | 106.3 (93.3–121.2) | 110.3 (96.0–125.0)* | 105.3 (93.4–119.0) | 111.9 ± 25.3** |
| LVSVI, mL/m2 | 53.7 (47.5–60.1) | 53.2 (47.2–59.9) | 55.0 (48.2–61.6)* | 53.2 (47.3–59.8) | 53.7 (47.1–60.9) |
| LVEF, % | 64.6 (59.2–70.2) | 64.7 (59.5–70.0) | 64.5 (58.8–70.5) | 64.6 (59.3–69.8) | 65.7 (60.7–71.4) |
| LVM, g | 165.1 (128.8–199.3) | 159.0 (125.6–190.4) | 171.7 ± 58.6* | 156.9 (125.2–183.7) | 198.0 ± 70.2** |
| LVMI, g/m2 | 81.6 (65.5–96.7) | 78.9 (64.3–92.4) | 94.4 (74.3–115.3)* | 78.3 (63.9–91.3) | 97.1 ± 30.0** |
| LGE | 1169 (50) | 627 (48) | 208 (48) | 673 (52) | 190 (44) |
| LVOT drop rest, mmHg | 7.9 (3.0–12.0) | 64.1 (42.1–82.8)* | 5.6 (0.0–8.0) | 15.3 (9.9–21.0)** | |
| LVOT drop stress, mmHg | 8.6 (2.0–14.0) | 64.2 (42.0–85.0)** | |||
| . | Total (n = 2377) . | HCMR− (n = 1320) . | oHCMR+ (n = 438) . | HCMR-S− (n = 565) . | oHCMR-S+ (n = 273) . |
|---|---|---|---|---|---|
| Mean LVWT, mm | 8.5 (7.4–10.0) | 8.7 (7.4–10.0) | 8.8 (7.5–9.9) | 8.7 (7.3–10.1) | 8.9 (7.5–10.3) |
| Max LVWT, mm | 16.9 (14.2–20.3) | 17.5 (14.4–20.7) | 17.5 (14.6–20.1) | 17.4 (14.2–20.8) | 17.8 (14.7–20.7) |
| LVEDV, mL | 169.1 (143.8–195.3) | 167.3 (141.6–196.9) | 175.1 ± 42.5* | 169.3 ± 39.9 | 176.5 ± 42.5** |
| LVEDVI, mL/m2 | 84.2 (73.8–94.2) | 83.3 (73.1–93.7) | 86.4 (75.8–96.3)* | 83.3 (48.9–93.4) | 86.9 ± 16.7 |
| LVESV, mL | 60.9 (44.7–75.9) | 59.7 (44.6–74.1) | 62.9 (44.8–78.5) | 59.3 (44.5–74.1) | 59.9 (45.0–74.1) |
| LVESVI, mL/m2 | 30.1 (22.9–36.7) | 29.8 (22.7–36.2) | 30.9 (23.4–37.7) | 29.7 (23.0–36.0) | 28.9 (21.9–35.8) |
| LVSV, mL | 107.2 (94.3–121.9) | 106.3 (93.3–121.2) | 110.3 (96.0–125.0)* | 105.3 (93.4–119.0) | 111.9 ± 25.3** |
| LVSVI, mL/m2 | 53.7 (47.5–60.1) | 53.2 (47.2–59.9) | 55.0 (48.2–61.6)* | 53.2 (47.3–59.8) | 53.7 (47.1–60.9) |
| LVEF, % | 64.6 (59.2–70.2) | 64.7 (59.5–70.0) | 64.5 (58.8–70.5) | 64.6 (59.3–69.8) | 65.7 (60.7–71.4) |
| LVM, g | 165.1 (128.8–199.3) | 159.0 (125.6–190.4) | 171.7 ± 58.6* | 156.9 (125.2–183.7) | 198.0 ± 70.2** |
| LVMI, g/m2 | 81.6 (65.5–96.7) | 78.9 (64.3–92.4) | 94.4 (74.3–115.3)* | 78.3 (63.9–91.3) | 97.1 ± 30.0** |
| LGE | 1169 (50) | 627 (48) | 208 (48) | 673 (52) | 190 (44) |
| LVOT drop rest, mmHg | 7.9 (3.0–12.0) | 64.1 (42.1–82.8)* | 5.6 (0.0–8.0) | 15.3 (9.9–21.0)** | |
| LVOT drop stress, mmHg | 8.6 (2.0–14.0) | 64.2 (42.0–85.0)** | |||
Values are given as mean ± SD or median (25–75% percentiles) or n (% with respect to number of valid cases).
HCM, hypertrophic cardiomyopathy; HCMR-, HCM non-obstructive cases at rest; HCMR-S−, HCM non-obstructive cases at rest and stress; LVWT, left ventricular wall thickness; LVEDV, left ventricular end-diastolic volume; LVEDVI, left ventricular end-diastolic volume indexed; LVESV, left ventricular end-systolic volume; LVESVI, left ventricular end-systolic volume indexed; LVSV, left ventricular stroke volume; LVSVI, left ventricular stroke volume indexed; LVEF, left ventricular ejection fraction; LVM, left ventricular mass; LVMI, left ventricular mass index; LGE, presence of late gadolinium enhancement; LVOT, left ventricular outflow tract; oHCM, obstructive hypertrophic cardiomyopathy; oHCMR+, HCM obstructive cases at rest; oHCMR-S+, HCM obstructive cases at stress but not at rest. Mean and Max LVWT measures derived from the personalized 3D meshes. The rest of imaging characteristics were derived from CMR images.
P < 0.05 with respect to Group R−.
P < 0.05 with respect to Group R−S−. For more details, including the number of valid cases for each variable, see Supplementary materials. From the total number of cases in the HCMR cohort, only those used for discriminant analysis are reported.
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