Table 2.

Neuroendocrine profiles and rates of cryptorchidism/micropenis of isolated hypogonadotropic hypogonadism cohort by pubertal status (n = 242)

Absent puberty (TV < 4 mL) n = 144Partial puberty (TV≥4 mL) n = 98
Cryptorchidism (n, %)42 (29%)18 (18%)
Micropenis (n, %)40 (28%)a11 (11%)
Apulsatile LH secretion (n, %)134/144 (93%)51/98 (52%)
ȃDetectable LH (n, %)17/134 (13%)16/51 (31%)
ȃȃRange, IU/L1.62-9.101.70-4.50
ȃȃMedian, IU/L2.352.60
ȃȃMean ± SD, IU/L2.89 ± 1.852.88 ± 0.88
ȃDetectable FSH (n, %)27/134 (20%)17/51 (33%)
ȃȃRange, IU/L1.61-13.101.64-3.90
ȃȃMedian, IU/L2.301.80
ȃȃMean ± SD, IU/L3.08 ± 2.402.07 ± 0.58
pulsatile LH secretion10/144 (7%)47/98 (48%)
ȃDetectable LH (n, %)10/10 (100%)47/47 (100%)
ȃȃRange, IU/L2.70-10.201.70-12.40
ȃȃMedian, IU/L3.604.00
ȃȃMean ± SD, IU/L4.56 ± 2.294.81 ± 2.52
ȃDetectable FSH (n, %)9/10 (90%)45/47 (96%)
ȃȃRange, IU/L2.00-6.301.70-13.60
ȃȃMedian, IU/L5.053.96
ȃȃMean ± SD, IU/L4.50 ± 1.765.12 ± 2.92
Absent puberty (TV < 4 mL) n = 144Partial puberty (TV≥4 mL) n = 98
Cryptorchidism (n, %)42 (29%)18 (18%)
Micropenis (n, %)40 (28%)a11 (11%)
Apulsatile LH secretion (n, %)134/144 (93%)51/98 (52%)
ȃDetectable LH (n, %)17/134 (13%)16/51 (31%)
ȃȃRange, IU/L1.62-9.101.70-4.50
ȃȃMedian, IU/L2.352.60
ȃȃMean ± SD, IU/L2.89 ± 1.852.88 ± 0.88
ȃDetectable FSH (n, %)27/134 (20%)17/51 (33%)
ȃȃRange, IU/L1.61-13.101.64-3.90
ȃȃMedian, IU/L2.301.80
ȃȃMean ± SD, IU/L3.08 ± 2.402.07 ± 0.58
pulsatile LH secretion10/144 (7%)47/98 (48%)
ȃDetectable LH (n, %)10/10 (100%)47/47 (100%)
ȃȃRange, IU/L2.70-10.201.70-12.40
ȃȃMedian, IU/L3.604.00
ȃȃMean ± SD, IU/L4.56 ± 2.294.81 ± 2.52
ȃDetectable FSH (n, %)9/10 (90%)45/47 (96%)
ȃȃRange, IU/L2.00-6.301.70-13.60
ȃȃMedian, IU/L5.053.96
ȃȃMean ± SD, IU/L4.50 ± 1.765.12 ± 2.92

Abbreviations: FSH, follicle-stimulating hormone; LH, luteinizing hormone; TV, testicular volume.

P less than .05.

Table 2.

Neuroendocrine profiles and rates of cryptorchidism/micropenis of isolated hypogonadotropic hypogonadism cohort by pubertal status (n = 242)

Absent puberty (TV < 4 mL) n = 144Partial puberty (TV≥4 mL) n = 98
Cryptorchidism (n, %)42 (29%)18 (18%)
Micropenis (n, %)40 (28%)a11 (11%)
Apulsatile LH secretion (n, %)134/144 (93%)51/98 (52%)
ȃDetectable LH (n, %)17/134 (13%)16/51 (31%)
ȃȃRange, IU/L1.62-9.101.70-4.50
ȃȃMedian, IU/L2.352.60
ȃȃMean ± SD, IU/L2.89 ± 1.852.88 ± 0.88
ȃDetectable FSH (n, %)27/134 (20%)17/51 (33%)
ȃȃRange, IU/L1.61-13.101.64-3.90
ȃȃMedian, IU/L2.301.80
ȃȃMean ± SD, IU/L3.08 ± 2.402.07 ± 0.58
pulsatile LH secretion10/144 (7%)47/98 (48%)
ȃDetectable LH (n, %)10/10 (100%)47/47 (100%)
ȃȃRange, IU/L2.70-10.201.70-12.40
ȃȃMedian, IU/L3.604.00
ȃȃMean ± SD, IU/L4.56 ± 2.294.81 ± 2.52
ȃDetectable FSH (n, %)9/10 (90%)45/47 (96%)
ȃȃRange, IU/L2.00-6.301.70-13.60
ȃȃMedian, IU/L5.053.96
ȃȃMean ± SD, IU/L4.50 ± 1.765.12 ± 2.92
Absent puberty (TV < 4 mL) n = 144Partial puberty (TV≥4 mL) n = 98
Cryptorchidism (n, %)42 (29%)18 (18%)
Micropenis (n, %)40 (28%)a11 (11%)
Apulsatile LH secretion (n, %)134/144 (93%)51/98 (52%)
ȃDetectable LH (n, %)17/134 (13%)16/51 (31%)
ȃȃRange, IU/L1.62-9.101.70-4.50
ȃȃMedian, IU/L2.352.60
ȃȃMean ± SD, IU/L2.89 ± 1.852.88 ± 0.88
ȃDetectable FSH (n, %)27/134 (20%)17/51 (33%)
ȃȃRange, IU/L1.61-13.101.64-3.90
ȃȃMedian, IU/L2.301.80
ȃȃMean ± SD, IU/L3.08 ± 2.402.07 ± 0.58
pulsatile LH secretion10/144 (7%)47/98 (48%)
ȃDetectable LH (n, %)10/10 (100%)47/47 (100%)
ȃȃRange, IU/L2.70-10.201.70-12.40
ȃȃMedian, IU/L3.604.00
ȃȃMean ± SD, IU/L4.56 ± 2.294.81 ± 2.52
ȃDetectable FSH (n, %)9/10 (90%)45/47 (96%)
ȃȃRange, IU/L2.00-6.301.70-13.60
ȃȃMedian, IU/L5.053.96
ȃȃMean ± SD, IU/L4.50 ± 1.765.12 ± 2.92

Abbreviations: FSH, follicle-stimulating hormone; LH, luteinizing hormone; TV, testicular volume.

P less than .05.

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