| Week . | N . | Mean mUFC ± SD, µg/24 hours . | Median mUFC, µg/24 hours . | Reduction in mean mUFC from baseline, % . |
|---|---|---|---|---|
| 0 | 9 | 226.4 ± 140.3 (4.5 ± 2.8 × ULN) | 146.4 (2.9 × ULN) | — |
| 1 | 8 | 88.9 ± 39.3 (1.8 ± 0.8 × ULN) | 73.2 (1.5 × ULN) | 63 |
| 2 | 8 | 124.4 ± 86.2 (2.5 ± 1.7 × ULN) | 96.6 (1.9 × ULN) | 44 |
| 3 | 7 | 142.8 ± 67.0 (2.9 ± 1.3 × ULN) | 135.0 (2.7 × ULN) | 40 |
| 4 | 7 | 151.7 ± 123.4 (3.0 ± 2.5 × ULN) | 130.2 (2.6 × ULN) | 36 |
| Longitudinal model estimates | ||||
| Week | N | Least squares mean difference (reduction) from baseline | 95% CI | P value |
| 0 | 9 | — | — | — |
| 1 | 8 | 141.0 | 70.9-211.0 | 0.0003 |
| 2 | 8 | 100.3 | 42.1-158.5 | 0.002 |
| 3 | 7 | 88.7 | 13.2-164.2 | 0.023 |
| 4 | 7 | 84.7 | 40.3-129.2 | 0.0006 |
| Week . | N . | Mean mUFC ± SD, µg/24 hours . | Median mUFC, µg/24 hours . | Reduction in mean mUFC from baseline, % . |
|---|---|---|---|---|
| 0 | 9 | 226.4 ± 140.3 (4.5 ± 2.8 × ULN) | 146.4 (2.9 × ULN) | — |
| 1 | 8 | 88.9 ± 39.3 (1.8 ± 0.8 × ULN) | 73.2 (1.5 × ULN) | 63 |
| 2 | 8 | 124.4 ± 86.2 (2.5 ± 1.7 × ULN) | 96.6 (1.9 × ULN) | 44 |
| 3 | 7 | 142.8 ± 67.0 (2.9 ± 1.3 × ULN) | 135.0 (2.7 × ULN) | 40 |
| 4 | 7 | 151.7 ± 123.4 (3.0 ± 2.5 × ULN) | 130.2 (2.6 × ULN) | 36 |
| Longitudinal model estimates | ||||
| Week | N | Least squares mean difference (reduction) from baseline | 95% CI | P value |
| 0 | 9 | — | — | — |
| 1 | 8 | 141.0 | 70.9-211.0 | 0.0003 |
| 2 | 8 | 100.3 | 42.1-158.5 | 0.002 |
| 3 | 7 | 88.7 | 13.2-164.2 | 0.023 |
| 4 | 7 | 84.7 | 40.3-129.2 | 0.0006 |
The mUFC ULN = 50 µg/24 hours.
Abbreviations: mUFC, mean weekly urinary free cortisol in each individual patient; ULN, upper limit of normal.
| Week . | N . | Mean mUFC ± SD, µg/24 hours . | Median mUFC, µg/24 hours . | Reduction in mean mUFC from baseline, % . |
|---|---|---|---|---|
| 0 | 9 | 226.4 ± 140.3 (4.5 ± 2.8 × ULN) | 146.4 (2.9 × ULN) | — |
| 1 | 8 | 88.9 ± 39.3 (1.8 ± 0.8 × ULN) | 73.2 (1.5 × ULN) | 63 |
| 2 | 8 | 124.4 ± 86.2 (2.5 ± 1.7 × ULN) | 96.6 (1.9 × ULN) | 44 |
| 3 | 7 | 142.8 ± 67.0 (2.9 ± 1.3 × ULN) | 135.0 (2.7 × ULN) | 40 |
| 4 | 7 | 151.7 ± 123.4 (3.0 ± 2.5 × ULN) | 130.2 (2.6 × ULN) | 36 |
| Longitudinal model estimates | ||||
| Week | N | Least squares mean difference (reduction) from baseline | 95% CI | P value |
| 0 | 9 | — | — | — |
| 1 | 8 | 141.0 | 70.9-211.0 | 0.0003 |
| 2 | 8 | 100.3 | 42.1-158.5 | 0.002 |
| 3 | 7 | 88.7 | 13.2-164.2 | 0.023 |
| 4 | 7 | 84.7 | 40.3-129.2 | 0.0006 |
| Week . | N . | Mean mUFC ± SD, µg/24 hours . | Median mUFC, µg/24 hours . | Reduction in mean mUFC from baseline, % . |
|---|---|---|---|---|
| 0 | 9 | 226.4 ± 140.3 (4.5 ± 2.8 × ULN) | 146.4 (2.9 × ULN) | — |
| 1 | 8 | 88.9 ± 39.3 (1.8 ± 0.8 × ULN) | 73.2 (1.5 × ULN) | 63 |
| 2 | 8 | 124.4 ± 86.2 (2.5 ± 1.7 × ULN) | 96.6 (1.9 × ULN) | 44 |
| 3 | 7 | 142.8 ± 67.0 (2.9 ± 1.3 × ULN) | 135.0 (2.7 × ULN) | 40 |
| 4 | 7 | 151.7 ± 123.4 (3.0 ± 2.5 × ULN) | 130.2 (2.6 × ULN) | 36 |
| Longitudinal model estimates | ||||
| Week | N | Least squares mean difference (reduction) from baseline | 95% CI | P value |
| 0 | 9 | — | — | — |
| 1 | 8 | 141.0 | 70.9-211.0 | 0.0003 |
| 2 | 8 | 100.3 | 42.1-158.5 | 0.002 |
| 3 | 7 | 88.7 | 13.2-164.2 | 0.023 |
| 4 | 7 | 84.7 | 40.3-129.2 | 0.0006 |
The mUFC ULN = 50 µg/24 hours.
Abbreviations: mUFC, mean weekly urinary free cortisol in each individual patient; ULN, upper limit of normal.
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