Table 2.

Utilization Characteristics of Ceftolozane/Tazobactam

CharacteristicOverallBJIcUTIRTIIAIcSSTIBacteremia
(n = 126), No. (%)(n = 34), No. (%)(n = 29), No. (%)(n = 23), No. (%)(n = 20), No. (%)(n = 17), No. (%)(n = 3), No. (%)
OPAT duration, median (IQR), d21 (14–38)39 (26–42)14 (8–17)21 (14–29)21 (14–22)26 (19–54)41 (28–44)
C/T dosage per day, median (range)4.5
(1.125–9.0)
4.5
(2.25–9.0)
4.5
(2.25–4.5)
4.5
(2.25–9.0)
4.5
(1.125–4.5)
4.5
(2.25–4.5)
4.5
(1.125–9.0)
 <4.5 g23 (18)5 (15)10 (34)2 (9)2 (10)3 (18)1 (33)
 >4.5 g7 (6)3 (9)3 (13)1 (33)
Frequency of infusion
 Intermittent123 (98)33 (97)29 (100)23 (100)20 (100)16 (94)2 (67)
 Continuous3 (2)1 (3)1 (6)1 (33)
Method of administration
 Elastomeric pump, self-administration at home83 (66)28 (82)14 (48)10 (43)16 (80)13 (76)2 (67)
 Ambulatory pump, daily pump bag changes in OIC42 (33)6 (18)14 (48)13 (57)4 (20)4 (24)1 (33)
 Stationary pump, daily administration in OIC1 (1)
Concomitant intravenous antibiotic therapy16 (13)9 (26)1 (3)1 (4)5 (29)
CharacteristicOverallBJIcUTIRTIIAIcSSTIBacteremia
(n = 126), No. (%)(n = 34), No. (%)(n = 29), No. (%)(n = 23), No. (%)(n = 20), No. (%)(n = 17), No. (%)(n = 3), No. (%)
OPAT duration, median (IQR), d21 (14–38)39 (26–42)14 (8–17)21 (14–29)21 (14–22)26 (19–54)41 (28–44)
C/T dosage per day, median (range)4.5
(1.125–9.0)
4.5
(2.25–9.0)
4.5
(2.25–4.5)
4.5
(2.25–9.0)
4.5
(1.125–4.5)
4.5
(2.25–4.5)
4.5
(1.125–9.0)
 <4.5 g23 (18)5 (15)10 (34)2 (9)2 (10)3 (18)1 (33)
 >4.5 g7 (6)3 (9)3 (13)1 (33)
Frequency of infusion
 Intermittent123 (98)33 (97)29 (100)23 (100)20 (100)16 (94)2 (67)
 Continuous3 (2)1 (3)1 (6)1 (33)
Method of administration
 Elastomeric pump, self-administration at home83 (66)28 (82)14 (48)10 (43)16 (80)13 (76)2 (67)
 Ambulatory pump, daily pump bag changes in OIC42 (33)6 (18)14 (48)13 (57)4 (20)4 (24)1 (33)
 Stationary pump, daily administration in OIC1 (1)
Concomitant intravenous antibiotic therapy16 (13)9 (26)1 (3)1 (4)5 (29)

Abbreviations: C/T, ceftolozane/tazobactam; IQR, interquartile range; OIC, physician office infusion center; OPAT, outpatient antimicrobial therapy.

Values are expressed as number of patients (%), unless otherwise indicated.

Daptomycin (n = 10), vancomycin (n = 5), televancin (n = 1).

Table 2.

Utilization Characteristics of Ceftolozane/Tazobactam

CharacteristicOverallBJIcUTIRTIIAIcSSTIBacteremia
(n = 126), No. (%)(n = 34), No. (%)(n = 29), No. (%)(n = 23), No. (%)(n = 20), No. (%)(n = 17), No. (%)(n = 3), No. (%)
OPAT duration, median (IQR), d21 (14–38)39 (26–42)14 (8–17)21 (14–29)21 (14–22)26 (19–54)41 (28–44)
C/T dosage per day, median (range)4.5
(1.125–9.0)
4.5
(2.25–9.0)
4.5
(2.25–4.5)
4.5
(2.25–9.0)
4.5
(1.125–4.5)
4.5
(2.25–4.5)
4.5
(1.125–9.0)
 <4.5 g23 (18)5 (15)10 (34)2 (9)2 (10)3 (18)1 (33)
 >4.5 g7 (6)3 (9)3 (13)1 (33)
Frequency of infusion
 Intermittent123 (98)33 (97)29 (100)23 (100)20 (100)16 (94)2 (67)
 Continuous3 (2)1 (3)1 (6)1 (33)
Method of administration
 Elastomeric pump, self-administration at home83 (66)28 (82)14 (48)10 (43)16 (80)13 (76)2 (67)
 Ambulatory pump, daily pump bag changes in OIC42 (33)6 (18)14 (48)13 (57)4 (20)4 (24)1 (33)
 Stationary pump, daily administration in OIC1 (1)
Concomitant intravenous antibiotic therapy16 (13)9 (26)1 (3)1 (4)5 (29)
CharacteristicOverallBJIcUTIRTIIAIcSSTIBacteremia
(n = 126), No. (%)(n = 34), No. (%)(n = 29), No. (%)(n = 23), No. (%)(n = 20), No. (%)(n = 17), No. (%)(n = 3), No. (%)
OPAT duration, median (IQR), d21 (14–38)39 (26–42)14 (8–17)21 (14–29)21 (14–22)26 (19–54)41 (28–44)
C/T dosage per day, median (range)4.5
(1.125–9.0)
4.5
(2.25–9.0)
4.5
(2.25–4.5)
4.5
(2.25–9.0)
4.5
(1.125–4.5)
4.5
(2.25–4.5)
4.5
(1.125–9.0)
 <4.5 g23 (18)5 (15)10 (34)2 (9)2 (10)3 (18)1 (33)
 >4.5 g7 (6)3 (9)3 (13)1 (33)
Frequency of infusion
 Intermittent123 (98)33 (97)29 (100)23 (100)20 (100)16 (94)2 (67)
 Continuous3 (2)1 (3)1 (6)1 (33)
Method of administration
 Elastomeric pump, self-administration at home83 (66)28 (82)14 (48)10 (43)16 (80)13 (76)2 (67)
 Ambulatory pump, daily pump bag changes in OIC42 (33)6 (18)14 (48)13 (57)4 (20)4 (24)1 (33)
 Stationary pump, daily administration in OIC1 (1)
Concomitant intravenous antibiotic therapy16 (13)9 (26)1 (3)1 (4)5 (29)

Abbreviations: C/T, ceftolozane/tazobactam; IQR, interquartile range; OIC, physician office infusion center; OPAT, outpatient antimicrobial therapy.

Values are expressed as number of patients (%), unless otherwise indicated.

Daptomycin (n = 10), vancomycin (n = 5), televancin (n = 1).

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