Largest mediation estimates by BMI in the associations between the HTT CAG repeats and metabolite levels
| Metabolite . | Mediation estimate . | Direct effect estimate . | Total effect estimate . | Sobel’s test P-value . |
|---|---|---|---|---|
| Phospholipids in very large HDL | 0.0013 | –0.0031 | –0.0017 | 0.0060 |
| Free cholesterol in very large HDL | 0.0011 | –0.0032 | –0.0020 | 0.0063 |
| Total lipids in very large HDL | 0.0010 | –0.0027 | –0.0017 | 0.0064 |
| Concentration of very large HDL particles | 0.0010 | –0.0027 | –0.0016 | 0.0063 |
| Total cholesterol in very large HDL | 0.0009 | –0.0025 | –0.0016 | 0.0069 |
| Cholesterol esters in very large HDL | 0.0009 | –0.0024 | –0.0015 | 0.0072 |
| Phospholipids in XL-VLDL | –0.0021 | 0.0052 | 0.0031 | 0.0060 |
| Cholesterol esters in XL-VLDL | –0.0018 | 0.0060 | 0.0042 | 0.0071 |
| Metabolite . | Mediation estimate . | Direct effect estimate . | Total effect estimate . | Sobel’s test P-value . |
|---|---|---|---|---|
| Phospholipids in very large HDL | 0.0013 | –0.0031 | –0.0017 | 0.0060 |
| Free cholesterol in very large HDL | 0.0011 | –0.0032 | –0.0020 | 0.0063 |
| Total lipids in very large HDL | 0.0010 | –0.0027 | –0.0017 | 0.0064 |
| Concentration of very large HDL particles | 0.0010 | –0.0027 | –0.0016 | 0.0063 |
| Total cholesterol in very large HDL | 0.0009 | –0.0025 | –0.0016 | 0.0069 |
| Cholesterol esters in very large HDL | 0.0009 | –0.0024 | –0.0015 | 0.0072 |
| Phospholipids in XL-VLDL | –0.0021 | 0.0052 | 0.0031 | 0.0060 |
| Cholesterol esters in XL-VLDL | –0.0018 | 0.0060 | 0.0042 | 0.0071 |
Largest mediation estimates by BMI in the associations between the HTT CAG repeats and metabolite levels
| Metabolite . | Mediation estimate . | Direct effect estimate . | Total effect estimate . | Sobel’s test P-value . |
|---|---|---|---|---|
| Phospholipids in very large HDL | 0.0013 | –0.0031 | –0.0017 | 0.0060 |
| Free cholesterol in very large HDL | 0.0011 | –0.0032 | –0.0020 | 0.0063 |
| Total lipids in very large HDL | 0.0010 | –0.0027 | –0.0017 | 0.0064 |
| Concentration of very large HDL particles | 0.0010 | –0.0027 | –0.0016 | 0.0063 |
| Total cholesterol in very large HDL | 0.0009 | –0.0025 | –0.0016 | 0.0069 |
| Cholesterol esters in very large HDL | 0.0009 | –0.0024 | –0.0015 | 0.0072 |
| Phospholipids in XL-VLDL | –0.0021 | 0.0052 | 0.0031 | 0.0060 |
| Cholesterol esters in XL-VLDL | –0.0018 | 0.0060 | 0.0042 | 0.0071 |
| Metabolite . | Mediation estimate . | Direct effect estimate . | Total effect estimate . | Sobel’s test P-value . |
|---|---|---|---|---|
| Phospholipids in very large HDL | 0.0013 | –0.0031 | –0.0017 | 0.0060 |
| Free cholesterol in very large HDL | 0.0011 | –0.0032 | –0.0020 | 0.0063 |
| Total lipids in very large HDL | 0.0010 | –0.0027 | –0.0017 | 0.0064 |
| Concentration of very large HDL particles | 0.0010 | –0.0027 | –0.0016 | 0.0063 |
| Total cholesterol in very large HDL | 0.0009 | –0.0025 | –0.0016 | 0.0069 |
| Cholesterol esters in very large HDL | 0.0009 | –0.0024 | –0.0015 | 0.0072 |
| Phospholipids in XL-VLDL | –0.0021 | 0.0052 | 0.0031 | 0.0060 |
| Cholesterol esters in XL-VLDL | –0.0018 | 0.0060 | 0.0042 | 0.0071 |
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