Table 1
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Populations of inflammatory cells present in the spinal cord at various times following the injection of LPS or saline into the dorsal funiculus

Number of cells in various regions of transverse sections of spinal cord*
Total
DF
WM
GM
Men
LPS injection
    8 h
        Macrophages/microglia†174 ± 26§110 ± 918 ± 184 ± 342 ± 12
        T-lymphocytes†26 ± 120 ± 00 ± 00 ± 026 ± 12
        Polymorphonuclear cells‡526 ± 84170 ± 3872 ± 18117 ± 23167 ± 35
    1 day
        Macrophages/microglia931 ± 135384 ± 5437 ± 18437 ± 16673 ± 18
        T-lymphocytes45 ± 100 ± 00 ± 00 ± 045 ± 10
        Polymorphonuclear cells134 ± 130 ± 413 ± 378 ± 1613 ± 5
    3 days
        Macrophages/microglia413 ± 21259 ± 3016 ± 759 ± 1579 ± 13
        T-lymphocytes8 ± 80 ± 00 ± 00 ± 08 ± 8
        Polymorphonuclear cells15 ± 26 ± 10 ± 06 ± 23 ± 2
    7 days
        Macrophages/microglia145 ± 13104 ± 131 ± 121 ± 1619 ± 13
        T-lymphocytes114 ± 2087 ± 341 ± 119 ± 147 ± 4
        Polymorphonuclear cells11 ± 15 ± 10 ± 04 ± 22 ± 2
    14 days
        Macrophages/microglia194 ± 13164 ± 155 ± 39 ± 216 ± 6
        T-lymphocytes4 ± 21 ± 10 ± 00 ± 03 ± 2
        Polymorphonuclear cells20 ± 56 ± 10 ± 08 ± 36 ± 4
    28 days
        Macrophages/microglia161 ± 77127 ± 598 ± 511 ± 915 ± 10
        T-lymphocytes1 ± 10 ± 00 ± 00 ± 01 ± 1
        Polymorphonuclear cells4 ± 30 ± 00 ± 01 ± 13 ± 2
Saline injection
    8 h
        Polymorphonuclear cells1611113
    7 days
        T-lymphocytes30012
        Macrophages/microglia57193926
Number of cells in various regions of transverse sections of spinal cord*
Total
DF
WM
GM
Men
LPS injection
    8 h
        Macrophages/microglia†174 ± 26§110 ± 918 ± 184 ± 342 ± 12
        T-lymphocytes†26 ± 120 ± 00 ± 00 ± 026 ± 12
        Polymorphonuclear cells‡526 ± 84170 ± 3872 ± 18117 ± 23167 ± 35
    1 day
        Macrophages/microglia931 ± 135384 ± 5437 ± 18437 ± 16673 ± 18
        T-lymphocytes45 ± 100 ± 00 ± 00 ± 045 ± 10
        Polymorphonuclear cells134 ± 130 ± 413 ± 378 ± 1613 ± 5
    3 days
        Macrophages/microglia413 ± 21259 ± 3016 ± 759 ± 1579 ± 13
        T-lymphocytes8 ± 80 ± 00 ± 00 ± 08 ± 8
        Polymorphonuclear cells15 ± 26 ± 10 ± 06 ± 23 ± 2
    7 days
        Macrophages/microglia145 ± 13104 ± 131 ± 121 ± 1619 ± 13
        T-lymphocytes114 ± 2087 ± 341 ± 119 ± 147 ± 4
        Polymorphonuclear cells11 ± 15 ± 10 ± 04 ± 22 ± 2
    14 days
        Macrophages/microglia194 ± 13164 ± 155 ± 39 ± 216 ± 6
        T-lymphocytes4 ± 21 ± 10 ± 00 ± 03 ± 2
        Polymorphonuclear cells20 ± 56 ± 10 ± 08 ± 36 ± 4
    28 days
        Macrophages/microglia161 ± 77127 ± 598 ± 511 ± 915 ± 10
        T-lymphocytes1 ± 10 ± 00 ± 00 ± 01 ± 1
        Polymorphonuclear cells4 ± 30 ± 00 ± 01 ± 13 ± 2
Saline injection
    8 h
        Polymorphonuclear cells1611113
    7 days
        T-lymphocytes30012
        Macrophages/microglia57193926
*

DF = dorsal funiculus; WM = white matter other than dorsal funiculus; GM = grey matter; Men. = meninges.

†

Counts of 25 µm thick transverse sections

‡

counts of 0.7 µm thick transverse sections

§

mean ± SEM.

Table 1
Open in new tab

Populations of inflammatory cells present in the spinal cord at various times following the injection of LPS or saline into the dorsal funiculus

Number of cells in various regions of transverse sections of spinal cord*
Total
DF
WM
GM
Men
LPS injection
    8 h
        Macrophages/microglia†174 ± 26§110 ± 918 ± 184 ± 342 ± 12
        T-lymphocytes†26 ± 120 ± 00 ± 00 ± 026 ± 12
        Polymorphonuclear cells‡526 ± 84170 ± 3872 ± 18117 ± 23167 ± 35
    1 day
        Macrophages/microglia931 ± 135384 ± 5437 ± 18437 ± 16673 ± 18
        T-lymphocytes45 ± 100 ± 00 ± 00 ± 045 ± 10
        Polymorphonuclear cells134 ± 130 ± 413 ± 378 ± 1613 ± 5
    3 days
        Macrophages/microglia413 ± 21259 ± 3016 ± 759 ± 1579 ± 13
        T-lymphocytes8 ± 80 ± 00 ± 00 ± 08 ± 8
        Polymorphonuclear cells15 ± 26 ± 10 ± 06 ± 23 ± 2
    7 days
        Macrophages/microglia145 ± 13104 ± 131 ± 121 ± 1619 ± 13
        T-lymphocytes114 ± 2087 ± 341 ± 119 ± 147 ± 4
        Polymorphonuclear cells11 ± 15 ± 10 ± 04 ± 22 ± 2
    14 days
        Macrophages/microglia194 ± 13164 ± 155 ± 39 ± 216 ± 6
        T-lymphocytes4 ± 21 ± 10 ± 00 ± 03 ± 2
        Polymorphonuclear cells20 ± 56 ± 10 ± 08 ± 36 ± 4
    28 days
        Macrophages/microglia161 ± 77127 ± 598 ± 511 ± 915 ± 10
        T-lymphocytes1 ± 10 ± 00 ± 00 ± 01 ± 1
        Polymorphonuclear cells4 ± 30 ± 00 ± 01 ± 13 ± 2
Saline injection
    8 h
        Polymorphonuclear cells1611113
    7 days
        T-lymphocytes30012
        Macrophages/microglia57193926
Number of cells in various regions of transverse sections of spinal cord*
Total
DF
WM
GM
Men
LPS injection
    8 h
        Macrophages/microglia†174 ± 26§110 ± 918 ± 184 ± 342 ± 12
        T-lymphocytes†26 ± 120 ± 00 ± 00 ± 026 ± 12
        Polymorphonuclear cells‡526 ± 84170 ± 3872 ± 18117 ± 23167 ± 35
    1 day
        Macrophages/microglia931 ± 135384 ± 5437 ± 18437 ± 16673 ± 18
        T-lymphocytes45 ± 100 ± 00 ± 00 ± 045 ± 10
        Polymorphonuclear cells134 ± 130 ± 413 ± 378 ± 1613 ± 5
    3 days
        Macrophages/microglia413 ± 21259 ± 3016 ± 759 ± 1579 ± 13
        T-lymphocytes8 ± 80 ± 00 ± 00 ± 08 ± 8
        Polymorphonuclear cells15 ± 26 ± 10 ± 06 ± 23 ± 2
    7 days
        Macrophages/microglia145 ± 13104 ± 131 ± 121 ± 1619 ± 13
        T-lymphocytes114 ± 2087 ± 341 ± 119 ± 147 ± 4
        Polymorphonuclear cells11 ± 15 ± 10 ± 04 ± 22 ± 2
    14 days
        Macrophages/microglia194 ± 13164 ± 155 ± 39 ± 216 ± 6
        T-lymphocytes4 ± 21 ± 10 ± 00 ± 03 ± 2
        Polymorphonuclear cells20 ± 56 ± 10 ± 08 ± 36 ± 4
    28 days
        Macrophages/microglia161 ± 77127 ± 598 ± 511 ± 915 ± 10
        T-lymphocytes1 ± 10 ± 00 ± 00 ± 01 ± 1
        Polymorphonuclear cells4 ± 30 ± 00 ± 01 ± 13 ± 2
Saline injection
    8 h
        Polymorphonuclear cells1611113
    7 days
        T-lymphocytes30012
        Macrophages/microglia57193926
*

DF = dorsal funiculus; WM = white matter other than dorsal funiculus; GM = grey matter; Men. = meninges.

†

Counts of 25 µm thick transverse sections

‡

counts of 0.7 µm thick transverse sections

§

mean ± SEM.

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