Estrogen pharmacology: indications, oral formulations, and doses of commonly prescribed estrogen compounds
| Indication . | Oral formulation or type . | Daily therapy doses . |
|---|---|---|
| Estrogen replacement | Micronized 17β-estradiola | 1-2 mg |
| Estradiol valerate | 1-2 mg | |
| Conjugated equine estrogen | 0.3-1.25 mg | |
| Contraception | Ethinyl estradiol | 20-50 μg |
| Other | SERM | |
| Osteoporosis | Raloxifene | 60 mg |
| Breast cancer prophylaxis | Tamoxifen | 20 mg |
| Infertility | Clomiphene | 50 mg |
| Indication . | Oral formulation or type . | Daily therapy doses . |
|---|---|---|
| Estrogen replacement | Micronized 17β-estradiola | 1-2 mg |
| Estradiol valerate | 1-2 mg | |
| Conjugated equine estrogen | 0.3-1.25 mg | |
| Contraception | Ethinyl estradiol | 20-50 μg |
| Other | SERM | |
| Osteoporosis | Raloxifene | 60 mg |
| Breast cancer prophylaxis | Tamoxifen | 20 mg |
| Infertility | Clomiphene | 50 mg |
Abbreviation: SERM, selective estrogen receptor modulator.
The average daily dose of 17β-estradiol for replacement therapy formulated in a patch delivered by the transdermal route is between 50 and 100 μg.
Estrogen pharmacology: indications, oral formulations, and doses of commonly prescribed estrogen compounds
| Indication . | Oral formulation or type . | Daily therapy doses . |
|---|---|---|
| Estrogen replacement | Micronized 17β-estradiola | 1-2 mg |
| Estradiol valerate | 1-2 mg | |
| Conjugated equine estrogen | 0.3-1.25 mg | |
| Contraception | Ethinyl estradiol | 20-50 μg |
| Other | SERM | |
| Osteoporosis | Raloxifene | 60 mg |
| Breast cancer prophylaxis | Tamoxifen | 20 mg |
| Infertility | Clomiphene | 50 mg |
| Indication . | Oral formulation or type . | Daily therapy doses . |
|---|---|---|
| Estrogen replacement | Micronized 17β-estradiola | 1-2 mg |
| Estradiol valerate | 1-2 mg | |
| Conjugated equine estrogen | 0.3-1.25 mg | |
| Contraception | Ethinyl estradiol | 20-50 μg |
| Other | SERM | |
| Osteoporosis | Raloxifene | 60 mg |
| Breast cancer prophylaxis | Tamoxifen | 20 mg |
| Infertility | Clomiphene | 50 mg |
Abbreviation: SERM, selective estrogen receptor modulator.
The average daily dose of 17β-estradiol for replacement therapy formulated in a patch delivered by the transdermal route is between 50 and 100 μg.
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