Table 1.

Inclusion and exclusion criteria decided by the steering group to determine patient eligibility for CATALYST

InclusionExclusion
Age ≥ 18 years
Labelled as penicillin allergic
Currently on or requiring antibiotic therapy
Capacity/ability to consent (e.g. no cognitive impairment)
Inpatient
Regular antihistamine
Regular immunosuppressant medication, including but not limited to: systemic anticancer treatments (SACT); disease-modifying anti-rheumatoid drugs (DMARDS); biologics
Taking corticosteroids at any dose (excluding topical and low-dose inhaled, e.g. beclomethasone 1000 μg/day or fluticasone 500 μg/day or equivalent). Note: must be 24 h clear of stat doses of corticosteroids, e.g. intra-operatively
Receiving inotropic support
Planning pregnancy or currently pregnant or breastfeeding
History of poorly controlled asthma
Clinical signs of severe allergy:
  • ȃcollapse requiring resuscitation

  • ȃitchy rash/urticaria (hives) with 1 h of dose

  • ȃblistering/peeling of skin

  • ȃoral/genital ulceration

  • ȃnew wheeze

  • ȃswelling of lips/tongue/eyes

  • ȃsevere renal/hepatic impairment following administration of penicillin

InclusionExclusion
Age ≥ 18 years
Labelled as penicillin allergic
Currently on or requiring antibiotic therapy
Capacity/ability to consent (e.g. no cognitive impairment)
Inpatient
Regular antihistamine
Regular immunosuppressant medication, including but not limited to: systemic anticancer treatments (SACT); disease-modifying anti-rheumatoid drugs (DMARDS); biologics
Taking corticosteroids at any dose (excluding topical and low-dose inhaled, e.g. beclomethasone 1000 μg/day or fluticasone 500 μg/day or equivalent). Note: must be 24 h clear of stat doses of corticosteroids, e.g. intra-operatively
Receiving inotropic support
Planning pregnancy or currently pregnant or breastfeeding
History of poorly controlled asthma
Clinical signs of severe allergy:
  • ȃcollapse requiring resuscitation

  • ȃitchy rash/urticaria (hives) with 1 h of dose

  • ȃblistering/peeling of skin

  • ȃoral/genital ulceration

  • ȃnew wheeze

  • ȃswelling of lips/tongue/eyes

  • ȃsevere renal/hepatic impairment following administration of penicillin

Table 1.

Inclusion and exclusion criteria decided by the steering group to determine patient eligibility for CATALYST

InclusionExclusion
Age ≥ 18 years
Labelled as penicillin allergic
Currently on or requiring antibiotic therapy
Capacity/ability to consent (e.g. no cognitive impairment)
Inpatient
Regular antihistamine
Regular immunosuppressant medication, including but not limited to: systemic anticancer treatments (SACT); disease-modifying anti-rheumatoid drugs (DMARDS); biologics
Taking corticosteroids at any dose (excluding topical and low-dose inhaled, e.g. beclomethasone 1000 μg/day or fluticasone 500 μg/day or equivalent). Note: must be 24 h clear of stat doses of corticosteroids, e.g. intra-operatively
Receiving inotropic support
Planning pregnancy or currently pregnant or breastfeeding
History of poorly controlled asthma
Clinical signs of severe allergy:
  • ȃcollapse requiring resuscitation

  • ȃitchy rash/urticaria (hives) with 1 h of dose

  • ȃblistering/peeling of skin

  • ȃoral/genital ulceration

  • ȃnew wheeze

  • ȃswelling of lips/tongue/eyes

  • ȃsevere renal/hepatic impairment following administration of penicillin

InclusionExclusion
Age ≥ 18 years
Labelled as penicillin allergic
Currently on or requiring antibiotic therapy
Capacity/ability to consent (e.g. no cognitive impairment)
Inpatient
Regular antihistamine
Regular immunosuppressant medication, including but not limited to: systemic anticancer treatments (SACT); disease-modifying anti-rheumatoid drugs (DMARDS); biologics
Taking corticosteroids at any dose (excluding topical and low-dose inhaled, e.g. beclomethasone 1000 μg/day or fluticasone 500 μg/day or equivalent). Note: must be 24 h clear of stat doses of corticosteroids, e.g. intra-operatively
Receiving inotropic support
Planning pregnancy or currently pregnant or breastfeeding
History of poorly controlled asthma
Clinical signs of severe allergy:
  • ȃcollapse requiring resuscitation

  • ȃitchy rash/urticaria (hives) with 1 h of dose

  • ȃblistering/peeling of skin

  • ȃoral/genital ulceration

  • ȃnew wheeze

  • ȃswelling of lips/tongue/eyes

  • ȃsevere renal/hepatic impairment following administration of penicillin

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