Predictors of progression to Alzheimer’s disease from stepwise logistic regression analysis
| Predictors . | Odds ratios . | 95% CI . | P . | . |
|---|---|---|---|---|
| Model with all four predictors | ||||
| (Intercept) | 0 | 0.00–0.00 | 0.012 | |
| Education (years) | 0.72 | 0.49–0.94 | 0.039 | |
| Average cell number (prol.) | 1.03 | 1.01–1.05 | 0.001 | |
| % Ki67+ cells (prol.) | 1.35 | 1.07–1.92 | 0.037 | |
| % CC3+ cells (diff.) | 3.49 | 1.42–11.85 | 0.016 | |
| Predictors | Odds ratios | 95% CI | P | AUC |
| Four models with one predictor each | ||||
| Education (years) | 0.79 | 0.66–0.92 | 0.004 | 0.756 |
| Average cell number (prol.) | 1.02 | 1.01–1.02 | <0.001 | 0.802 |
| % Ki67+ cells (prol.) | 1.04 | 0.94–1.16 | 0.399 | 0.573 |
| % CC3+ cells (diff.) | 2.67 | 1.48–5.72 | 0.004 | 0.782 |
| Predictors . | Odds ratios . | 95% CI . | P . | . |
|---|---|---|---|---|
| Model with all four predictors | ||||
| (Intercept) | 0 | 0.00–0.00 | 0.012 | |
| Education (years) | 0.72 | 0.49–0.94 | 0.039 | |
| Average cell number (prol.) | 1.03 | 1.01–1.05 | 0.001 | |
| % Ki67+ cells (prol.) | 1.35 | 1.07–1.92 | 0.037 | |
| % CC3+ cells (diff.) | 3.49 | 1.42–11.85 | 0.016 | |
| Predictors | Odds ratios | 95% CI | P | AUC |
| Four models with one predictor each | ||||
| Education (years) | 0.79 | 0.66–0.92 | 0.004 | 0.756 |
| Average cell number (prol.) | 1.02 | 1.01–1.02 | <0.001 | 0.802 |
| % Ki67+ cells (prol.) | 1.04 | 0.94–1.16 | 0.399 | 0.573 |
| % CC3+ cells (diff.) | 2.67 | 1.48–5.72 | 0.004 | 0.782 |
Top: The full logistic regression model including all four predictors: years of education, average cell number during proliferation, proliferation marker (Ki67) during proliferation and apoptosis marker (CC3) during differentiation stages of the assay. Bottom: Four logistic regression models with each predictor being the sole predictor of progression to Alzheimer’s disease. Odds ratios, 95% CI and P-values are shown. prol = proliferation assay; diff = differentiation assay.
Predictors of progression to Alzheimer’s disease from stepwise logistic regression analysis
| Predictors . | Odds ratios . | 95% CI . | P . | . |
|---|---|---|---|---|
| Model with all four predictors | ||||
| (Intercept) | 0 | 0.00–0.00 | 0.012 | |
| Education (years) | 0.72 | 0.49–0.94 | 0.039 | |
| Average cell number (prol.) | 1.03 | 1.01–1.05 | 0.001 | |
| % Ki67+ cells (prol.) | 1.35 | 1.07–1.92 | 0.037 | |
| % CC3+ cells (diff.) | 3.49 | 1.42–11.85 | 0.016 | |
| Predictors | Odds ratios | 95% CI | P | AUC |
| Four models with one predictor each | ||||
| Education (years) | 0.79 | 0.66–0.92 | 0.004 | 0.756 |
| Average cell number (prol.) | 1.02 | 1.01–1.02 | <0.001 | 0.802 |
| % Ki67+ cells (prol.) | 1.04 | 0.94–1.16 | 0.399 | 0.573 |
| % CC3+ cells (diff.) | 2.67 | 1.48–5.72 | 0.004 | 0.782 |
| Predictors . | Odds ratios . | 95% CI . | P . | . |
|---|---|---|---|---|
| Model with all four predictors | ||||
| (Intercept) | 0 | 0.00–0.00 | 0.012 | |
| Education (years) | 0.72 | 0.49–0.94 | 0.039 | |
| Average cell number (prol.) | 1.03 | 1.01–1.05 | 0.001 | |
| % Ki67+ cells (prol.) | 1.35 | 1.07–1.92 | 0.037 | |
| % CC3+ cells (diff.) | 3.49 | 1.42–11.85 | 0.016 | |
| Predictors | Odds ratios | 95% CI | P | AUC |
| Four models with one predictor each | ||||
| Education (years) | 0.79 | 0.66–0.92 | 0.004 | 0.756 |
| Average cell number (prol.) | 1.02 | 1.01–1.02 | <0.001 | 0.802 |
| % Ki67+ cells (prol.) | 1.04 | 0.94–1.16 | 0.399 | 0.573 |
| % CC3+ cells (diff.) | 2.67 | 1.48–5.72 | 0.004 | 0.782 |
Top: The full logistic regression model including all four predictors: years of education, average cell number during proliferation, proliferation marker (Ki67) during proliferation and apoptosis marker (CC3) during differentiation stages of the assay. Bottom: Four logistic regression models with each predictor being the sole predictor of progression to Alzheimer’s disease. Odds ratios, 95% CI and P-values are shown. prol = proliferation assay; diff = differentiation assay.
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