Table 1. Open in new tab Magnitude of...

Bacterial Reduction Endpoint	Sulbactam fT > MIC (%) by Mouse Infection Model
Net bacterial stasis	21.0	20.4
1-Log₁₀ CFU reduction from baseline	32.9	24.5
2-Log₁₀ CFU reduction from baseline	43.6	29.3
3-Log₁₀ CFU reduction from baseline	57.3	37.3

Bacterial Reduction Endpoint	Sulbactam fT > MIC (%) by Mouse Infection Model
Net bacterial stasis	21.0	20.4
1-Log₁₀ CFU reduction from baseline	32.9	24.5
2-Log₁₀ CFU reduction from baseline	43.6	29.3
3-Log₁₀ CFU reduction from baseline	57.3	37.3

Table 1.

Magnitude of Sulbactam fT > MIC Associated With Net Bacterial Stasis, and 1-, 2-, and 3-Log₁₀ CFU Reductions From Baseline Against Acinetobacter baumannii in Thigh and Lung Models

Bacterial Reduction Endpoint	Sulbactam fT > MIC (%) by Mouse Infection Model
Bacterial Reduction Endpoint	Thigh	Lung
Net bacterial stasis	21.0	20.4
1-Log₁₀ CFU reduction from baseline	32.9	24.5
2-Log₁₀ CFU reduction from baseline	43.6	29.3
3-Log₁₀ CFU reduction from baseline	57.3	37.3

Bacterial Reduction Endpoint	Sulbactam fT > MIC (%) by Mouse Infection Model
Bacterial Reduction Endpoint	Thigh	Lung
Net bacterial stasis	21.0	20.4
1-Log₁₀ CFU reduction from baseline	32.9	24.5
2-Log₁₀ CFU reduction from baseline	43.6	29.3
3-Log₁₀ CFU reduction from baseline	57.3	37.3

Data from reference [14]. Abbreviations: CFU, colony-forming units; fT > MIC, time that unbound drug concentration remains above the minimum inhibitory concentration.

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