Table 1. Open in new tab Clinical...

				Sample collection
1	Poor motility, germinolysis	None	No symptoms	0 M	Saliva	2.6 × 10⁹
3 M	Blood^a	2.5 × 10¹
	Saliva	NE
	Urine	4.0 × 10⁶
6 M	Blood^a	2.1 × 10²
	Saliva	NE
	Urine	2.8 × 10⁶
12 M	Blood^a	1.2 × 10¹
	Saliva	NE
	Urine	9.6 × 10⁵
2	IUGR, low platelet count, hepatitis, poor motility	GCV, vGCV	SNHL, hypotonia, tremors	0 M	Blood	2.7 × 10⁴
	Saliva	2.4 × 10⁸
	Urine	6.9 × 10⁶
3 M	Blood^a	1.2 × 10¹
	Saliva	7.2 × 10⁹
	Urine	8.4 × 10⁶
6 M	Blood^a	1.2 × 10²
	Saliva	NE
	Urine	4.1 × 10⁵
12 M	Blood^a	2.4 × 10¹
	Saliva	NE
	Urine	1.5 × 10³
3	Asymptomatic	None	No symptoms	0 M	Blood	8.4 × 10⁴
	Saliva	2.4 × 10⁸
	Urine	5.2 × 10⁶
3 M	Blood	2.2 × 10²
	Saliva	NE
	Urine	2.3 × 10⁶
6 M	Blood^a	8.7 × 10¹
	Saliva	NE
	Urine	6.2 × 10⁶
12 M	Blood^a	1.2 × 10¹
	Saliva^a	NE

Sample collection

Patient

Clinical findings at birth

Antiviral regime

Clinical findings at follow-up

Time point

Compartment

Viral load (IU/mL)

Poor motility, germinolysis

None

No symptoms

0 M

Saliva

2.6 × 10⁹

3 M

Blood^a

2.5 × 10¹

Saliva

Urine

4.0 × 10⁶

6 M

Blood^a

2.1 × 10²

Saliva

Urine

2.8 × 10⁶

12 M

Blood^a

1.2 × 10¹

Saliva

Urine

9.6 × 10⁵

IUGR, low platelet count, hepatitis, poor motility

GCV, vGCV

SNHL, hypotonia, tremors

0 M

Blood

2.7 × 10⁴

Saliva

2.4 × 10⁸

Urine

6.9 × 10⁶

3 M

Blood^a

1.2 × 10¹

Saliva

7.2 × 10⁹

Urine

8.4 × 10⁶

6 M

Blood^a

1.2 × 10²

Saliva

Urine

4.1 × 10⁵

12 M

Blood^a

2.4 × 10¹

Saliva

Urine

1.5 × 10³

Asymptomatic

None

No symptoms

0 M

Blood

8.4 × 10⁴

Saliva

2.4 × 10⁸

Urine

5.2 × 10⁶

3 M

Blood

2.2 × 10²

Saliva

Urine

2.3 × 10⁶

6 M

Blood^a

8.7 × 10¹

Saliva

Urine

6.2 × 10⁶

12 M

Blood^a

1.2 × 10¹

Saliva^a

				Sample collection
1	Poor motility, germinolysis	None	No symptoms	0 M	Saliva	2.6 × 10⁹
3 M	Blood^a	2.5 × 10¹
	Saliva	NE
	Urine	4.0 × 10⁶
6 M	Blood^a	2.1 × 10²
	Saliva	NE
	Urine	2.8 × 10⁶
12 M	Blood^a	1.2 × 10¹
	Saliva	NE
	Urine	9.6 × 10⁵
2	IUGR, low platelet count, hepatitis, poor motility	GCV, vGCV	SNHL, hypotonia, tremors	0 M	Blood	2.7 × 10⁴
	Saliva	2.4 × 10⁸
	Urine	6.9 × 10⁶
3 M	Blood^a	1.2 × 10¹
	Saliva	7.2 × 10⁹
	Urine	8.4 × 10⁶
6 M	Blood^a	1.2 × 10²
	Saliva	NE
	Urine	4.1 × 10⁵
12 M	Blood^a	2.4 × 10¹
	Saliva	NE
	Urine	1.5 × 10³
3	Asymptomatic	None	No symptoms	0 M	Blood	8.4 × 10⁴
	Saliva	2.4 × 10⁸
	Urine	5.2 × 10⁶
3 M	Blood	2.2 × 10²
	Saliva	NE
	Urine	2.3 × 10⁶
6 M	Blood^a	8.7 × 10¹
	Saliva	NE
	Urine	6.2 × 10⁶
12 M	Blood^a	1.2 × 10¹
	Saliva^a	NE

Table 1.

Open in new tab

Clinical information on the cohort.

				Sample collection
Patient	Clinical findings at birth	Antiviral regime	Clinical findings at follow-up	Time point	Compartment	Viral load (IU/mL)
1	Poor motility, germinolysis	None	No symptoms	0 M	Saliva	2.6 × 10⁹
				3 M	Blood^a	2.5 × 10¹
					Saliva	NE
					Urine	4.0 × 10⁶
				6 M	Blood^a	2.1 × 10²
					Saliva	NE
					Urine	2.8 × 10⁶
				12 M	Blood^a	1.2 × 10¹
					Saliva	NE
					Urine	9.6 × 10⁵
2	IUGR, low platelet count, hepatitis, poor motility	GCV, vGCV	SNHL, hypotonia, tremors	0 M	Blood	2.7 × 10⁴
					Saliva	2.4 × 10⁸
					Urine	6.9 × 10⁶
				3 M	Blood^a	1.2 × 10¹
					Saliva	7.2 × 10⁹
					Urine	8.4 × 10⁶
				6 M	Blood^a	1.2 × 10²
					Saliva	NE
					Urine	4.1 × 10⁵
				12 M	Blood^a	2.4 × 10¹
					Saliva	NE
					Urine	1.5 × 10³
3	Asymptomatic	None	No symptoms	0 M	Blood	8.4 × 10⁴
					Saliva	2.4 × 10⁸
					Urine	5.2 × 10⁶
				3 M	Blood	2.2 × 10²
					Saliva	NE
					Urine	2.3 × 10⁶
				6 M	Blood^a	8.7 × 10¹
					Saliva	NE
					Urine	6.2 × 10⁶
				12 M	Blood^a	1.2 × 10¹
					Saliva^a	NE

				Sample collection
Patient	Clinical findings at birth	Antiviral regime	Clinical findings at follow-up	Time point	Compartment	Viral load (IU/mL)
1	Poor motility, germinolysis	None	No symptoms	0 M	Saliva	2.6 × 10⁹
				3 M	Blood^a	2.5 × 10¹
					Saliva	NE
					Urine	4.0 × 10⁶
				6 M	Blood^a	2.1 × 10²
					Saliva	NE
					Urine	2.8 × 10⁶
				12 M	Blood^a	1.2 × 10¹
					Saliva	NE
					Urine	9.6 × 10⁵
2	IUGR, low platelet count, hepatitis, poor motility	GCV, vGCV	SNHL, hypotonia, tremors	0 M	Blood	2.7 × 10⁴
					Saliva	2.4 × 10⁸
					Urine	6.9 × 10⁶
				3 M	Blood^a	1.2 × 10¹
					Saliva	7.2 × 10⁹
					Urine	8.4 × 10⁶
				6 M	Blood^a	1.2 × 10²
					Saliva	NE
					Urine	4.1 × 10⁵
				12 M	Blood^a	2.4 × 10¹
					Saliva	NE
					Urine	1.5 × 10³
3	Asymptomatic	None	No symptoms	0 M	Blood	8.4 × 10⁴
					Saliva	2.4 × 10⁸
					Urine	5.2 × 10⁶
				3 M	Blood	2.2 × 10²
					Saliva	NE
					Urine	2.3 × 10⁶
				6 M	Blood^a	8.7 × 10¹
					Saliva	NE
					Urine	6.2 × 10⁶
				12 M	Blood^a	1.2 × 10¹
					Saliva^a	NE

Sequencing library not generated.

Abbreviations: 0 M, within 3 weeks; 3 M, 3 months; 6 M, 6 months; 12 M, 12 months; GCV, ganciclovir; vGCV, valganciclovir; IUGR, intrauterine growth restriction; SNHL, sensorineural hearing loss; NE, viral load not estimated.

This Feature Is Available To Subscribers Only