Table 3
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Therapeutic dosing regimen for danaparoid and lepirudin29

DrugWeightIV bolusIV infusionMonitoring
Danaparoid<60 kg1500 U400 U/h for first 4 h, 300 U/h for next 4 h, then 150–200 U/hAnti-Xa factor
60–74 kg2250 URange: 0.5–0.8 U/ml
75–90 kg3000 U
>90 kg3750 U
LepirudinMaximum 100 kg0.4 mg/kgStart at 0.15 mg/kg/h and titrate for target aPTTaPTT 1.5–2.5
Plasma concentration: 0.6–1.4 mg/l
DrugWeightIV bolusIV infusionMonitoring
Danaparoid<60 kg1500 U400 U/h for first 4 h, 300 U/h for next 4 h, then 150–200 U/hAnti-Xa factor
60–74 kg2250 URange: 0.5–0.8 U/ml
75–90 kg3000 U
>90 kg3750 U
LepirudinMaximum 100 kg0.4 mg/kgStart at 0.15 mg/kg/h and titrate for target aPTTaPTT 1.5–2.5
Plasma concentration: 0.6–1.4 mg/l

aPTT, activated partial thromboplastin time, IV, intravenous.

Table 3
Open in new tab

Therapeutic dosing regimen for danaparoid and lepirudin29

DrugWeightIV bolusIV infusionMonitoring
Danaparoid<60 kg1500 U400 U/h for first 4 h, 300 U/h for next 4 h, then 150–200 U/hAnti-Xa factor
60–74 kg2250 URange: 0.5–0.8 U/ml
75–90 kg3000 U
>90 kg3750 U
LepirudinMaximum 100 kg0.4 mg/kgStart at 0.15 mg/kg/h and titrate for target aPTTaPTT 1.5–2.5
Plasma concentration: 0.6–1.4 mg/l
DrugWeightIV bolusIV infusionMonitoring
Danaparoid<60 kg1500 U400 U/h for first 4 h, 300 U/h for next 4 h, then 150–200 U/hAnti-Xa factor
60–74 kg2250 URange: 0.5–0.8 U/ml
75–90 kg3000 U
>90 kg3750 U
LepirudinMaximum 100 kg0.4 mg/kgStart at 0.15 mg/kg/h and titrate for target aPTTaPTT 1.5–2.5
Plasma concentration: 0.6–1.4 mg/l

aPTT, activated partial thromboplastin time, IV, intravenous.

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