| Citation [reference] Follow-up time . | Comparison . | Study design . | Outcomes . | Participants (no studies) . | Effect . | Certainty of evidence (GRADE) . | Down rating (GRADE) . |
|---|---|---|---|---|---|---|---|
| Lev-Sagie et al, 201754 | Low level laser therapy – simulated treatment | RCT | Pain during intercourse (NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ |
| Pain at pressure or touch (cotton-swab test) NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ | |||
| After 6 wk treatment | Sexual satisfaction (proportion with negative effect on sexual life) | 34 (1) | NS | Very low | Precision -3‡ | ||
| Side-effects (proportion of participants) | 34 (1) | I: 0% C: 0% | Not assessed | ||||
| Morin et al, 201755 | Transcranial electric stimulation–simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 39 (1) | NS | Very low | Precision -3‡ |
| After 2 wk treatment | Sexual function (FSFI) | 39 (1) | NS | Very low | Precision -3‡ | ||
| Anxiety (State-Trait Anxiety Inventory of Spielberger, state domain) | 39(1) | NS | Very low | Precision -3‡ | |||
| Depression (BDI) | 39 (1) | NS | Very low | Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 39 (1) | Various, some* were significantly more frequent in the intervention group, others not | Not assessed | ||||
| Gruenwald et al, 202156 | Low intensity shock-wave therapy – simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 32† (1) | MD -2.6 (-4.0 to -1.2)†, favor shock-wave | Very low | Risk of bias -1¶ Precision -3§ |
| 1 mo after completed treatment | Pain at pressure or touch (vulvar-algesiometer, mm Hg) | 32† (1) | MD 7.8 (-2.4 to 18.0)† | Very low | Risk of bias -1¶ Precision -3§ | ||
| Sexual function (FSFI) | 32† (1) | MD -1.0 (-4.5 to 3.0)† | Very low | Risk of bias -1¶ Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 32 (1) | I: 4% C: 0% | Not assessed |
| Citation [reference] Follow-up time . | Comparison . | Study design . | Outcomes . | Participants (no studies) . | Effect . | Certainty of evidence (GRADE) . | Down rating (GRADE) . |
|---|---|---|---|---|---|---|---|
| Lev-Sagie et al, 201754 | Low level laser therapy – simulated treatment | RCT | Pain during intercourse (NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ |
| Pain at pressure or touch (cotton-swab test) NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ | |||
| After 6 wk treatment | Sexual satisfaction (proportion with negative effect on sexual life) | 34 (1) | NS | Very low | Precision -3‡ | ||
| Side-effects (proportion of participants) | 34 (1) | I: 0% C: 0% | Not assessed | ||||
| Morin et al, 201755 | Transcranial electric stimulation–simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 39 (1) | NS | Very low | Precision -3‡ |
| After 2 wk treatment | Sexual function (FSFI) | 39 (1) | NS | Very low | Precision -3‡ | ||
| Anxiety (State-Trait Anxiety Inventory of Spielberger, state domain) | 39(1) | NS | Very low | Precision -3‡ | |||
| Depression (BDI) | 39 (1) | NS | Very low | Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 39 (1) | Various, some* were significantly more frequent in the intervention group, others not | Not assessed | ||||
| Gruenwald et al, 202156 | Low intensity shock-wave therapy – simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 32† (1) | MD -2.6 (-4.0 to -1.2)†, favor shock-wave | Very low | Risk of bias -1¶ Precision -3§ |
| 1 mo after completed treatment | Pain at pressure or touch (vulvar-algesiometer, mm Hg) | 32† (1) | MD 7.8 (-2.4 to 18.0)† | Very low | Risk of bias -1¶ Precision -3§ | ||
| Sexual function (FSFI) | 32† (1) | MD -1.0 (-4.5 to 3.0)† | Very low | Risk of bias -1¶ Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 32 (1) | I: 4% C: 0% | Not assessed |
Burning sensation, erythema, itch.
Calculation was made since no analysis of differences between groups were reported in the study. Some uncertainty exists regarding the correct number of participants for the various outcomes.
Small study population, only 1 study, no statistical significant results.
Small study population, only 1 study.
Some shortcomings concerning randomization and reporting.
BDI = Beck Depression Inventory (0–63); C = control; CI = confidence interval; FSFI = Female Sexual Function Index (2–36); I = intervention; MD = mean difference; NRS = Numeric Rating Scale; NS = non-statistical significant difference; RCT = randomized controlled trial; VAS = Visual analogue scale.
| Citation [reference] Follow-up time . | Comparison . | Study design . | Outcomes . | Participants (no studies) . | Effect . | Certainty of evidence (GRADE) . | Down rating (GRADE) . |
|---|---|---|---|---|---|---|---|
| Lev-Sagie et al, 201754 | Low level laser therapy – simulated treatment | RCT | Pain during intercourse (NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ |
| Pain at pressure or touch (cotton-swab test) NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ | |||
| After 6 wk treatment | Sexual satisfaction (proportion with negative effect on sexual life) | 34 (1) | NS | Very low | Precision -3‡ | ||
| Side-effects (proportion of participants) | 34 (1) | I: 0% C: 0% | Not assessed | ||||
| Morin et al, 201755 | Transcranial electric stimulation–simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 39 (1) | NS | Very low | Precision -3‡ |
| After 2 wk treatment | Sexual function (FSFI) | 39 (1) | NS | Very low | Precision -3‡ | ||
| Anxiety (State-Trait Anxiety Inventory of Spielberger, state domain) | 39(1) | NS | Very low | Precision -3‡ | |||
| Depression (BDI) | 39 (1) | NS | Very low | Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 39 (1) | Various, some* were significantly more frequent in the intervention group, others not | Not assessed | ||||
| Gruenwald et al, 202156 | Low intensity shock-wave therapy – simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 32† (1) | MD -2.6 (-4.0 to -1.2)†, favor shock-wave | Very low | Risk of bias -1¶ Precision -3§ |
| 1 mo after completed treatment | Pain at pressure or touch (vulvar-algesiometer, mm Hg) | 32† (1) | MD 7.8 (-2.4 to 18.0)† | Very low | Risk of bias -1¶ Precision -3§ | ||
| Sexual function (FSFI) | 32† (1) | MD -1.0 (-4.5 to 3.0)† | Very low | Risk of bias -1¶ Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 32 (1) | I: 4% C: 0% | Not assessed |
| Citation [reference] Follow-up time . | Comparison . | Study design . | Outcomes . | Participants (no studies) . | Effect . | Certainty of evidence (GRADE) . | Down rating (GRADE) . |
|---|---|---|---|---|---|---|---|
| Lev-Sagie et al, 201754 | Low level laser therapy – simulated treatment | RCT | Pain during intercourse (NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ |
| Pain at pressure or touch (cotton-swab test) NRS 0–10) | 34 (1) | NS | Very low | Precision -3‡ | |||
| After 6 wk treatment | Sexual satisfaction (proportion with negative effect on sexual life) | 34 (1) | NS | Very low | Precision -3‡ | ||
| Side-effects (proportion of participants) | 34 (1) | I: 0% C: 0% | Not assessed | ||||
| Morin et al, 201755 | Transcranial electric stimulation–simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 39 (1) | NS | Very low | Precision -3‡ |
| After 2 wk treatment | Sexual function (FSFI) | 39 (1) | NS | Very low | Precision -3‡ | ||
| Anxiety (State-Trait Anxiety Inventory of Spielberger, state domain) | 39(1) | NS | Very low | Precision -3‡ | |||
| Depression (BDI) | 39 (1) | NS | Very low | Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 39 (1) | Various, some* were significantly more frequent in the intervention group, others not | Not assessed | ||||
| Gruenwald et al, 202156 | Low intensity shock-wave therapy – simulated treatment | RCT | Pain during intercourse (VAS 0–10) | 32† (1) | MD -2.6 (-4.0 to -1.2)†, favor shock-wave | Very low | Risk of bias -1¶ Precision -3§ |
| 1 mo after completed treatment | Pain at pressure or touch (vulvar-algesiometer, mm Hg) | 32† (1) | MD 7.8 (-2.4 to 18.0)† | Very low | Risk of bias -1¶ Precision -3§ | ||
| Sexual function (FSFI) | 32† (1) | MD -1.0 (-4.5 to 3.0)† | Very low | Risk of bias -1¶ Precision -3‡ | |||
| Mild side-effects (proportion of participants) | 32 (1) | I: 4% C: 0% | Not assessed |
Burning sensation, erythema, itch.
Calculation was made since no analysis of differences between groups were reported in the study. Some uncertainty exists regarding the correct number of participants for the various outcomes.
Small study population, only 1 study, no statistical significant results.
Small study population, only 1 study.
Some shortcomings concerning randomization and reporting.
BDI = Beck Depression Inventory (0–63); C = control; CI = confidence interval; FSFI = Female Sexual Function Index (2–36); I = intervention; MD = mean difference; NRS = Numeric Rating Scale; NS = non-statistical significant difference; RCT = randomized controlled trial; VAS = Visual analogue scale.
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