| Primary tumor (T) |
| ȃ• TX: primary tumor cannot be assessed |
| ȃ• T1: PHEO < 5 cm in greatest dimension, no extra-adrenal invasion |
| ȃ• T2: PHEO ≥ 5 cm OR sympathetic PGL of any size, no extra-adrenal invasion |
| ȃ• T3: Tumor of any size with invasion into surrounding tissuesb |
| Regional lymph nodes (N) |
| ȃ• NX: regional lymph nodes cannot be assessed |
| ȃ• N0: no regional lymph node metastasis |
| ȃ• N1: regional lymph node metastasis |
| Distant metastasis (M) |
| ȃ• M0: no distant metastasis |
| ȃ• M1: distant metastasis |
| ȃȃ• M1a: metastasis to bone only |
| ȃȃ• M1b: metastasis to non-regional lymph node(s), liver, and/or lung; no skeletal metastases |
| ȃȃ• M1c: metastasis to bone and multiple other sites |
| AJCC prognostic stage groups |
| ȃ• Stage I: T1 N0 M0 |
| ȃ• Stage II: T2 N0 M0 |
| ȃ• Stage III: T1-2 N1 M0 or T3 N0-1 M0 |
| ȃ• Stage IV: T1-3 N0-1 M1 |
| Primary tumor (T) |
| ȃ• TX: primary tumor cannot be assessed |
| ȃ• T1: PHEO < 5 cm in greatest dimension, no extra-adrenal invasion |
| ȃ• T2: PHEO ≥ 5 cm OR sympathetic PGL of any size, no extra-adrenal invasion |
| ȃ• T3: Tumor of any size with invasion into surrounding tissuesb |
| Regional lymph nodes (N) |
| ȃ• NX: regional lymph nodes cannot be assessed |
| ȃ• N0: no regional lymph node metastasis |
| ȃ• N1: regional lymph node metastasis |
| Distant metastasis (M) |
| ȃ• M0: no distant metastasis |
| ȃ• M1: distant metastasis |
| ȃȃ• M1a: metastasis to bone only |
| ȃȃ• M1b: metastasis to non-regional lymph node(s), liver, and/or lung; no skeletal metastases |
| ȃȃ• M1c: metastasis to bone and multiple other sites |
| AJCC prognostic stage groups |
| ȃ• Stage I: T1 N0 M0 |
| ȃ• Stage II: T2 N0 M0 |
| ȃ• Stage III: T1-2 N1 M0 or T3 N0-1 M0 |
| ȃ• Stage IV: T1-3 N0-1 M1 |
Abbreviations: PGL, paraganglioma; PHEO, pheochromocytoma; PPGL, pheochromocytoma/paraganglioma.
Jimenez et al (11).
As per AJCC definitions, invasion into surrounding tissues includes any involvement outside the wall/capsule of any organ. For adrenal tumors, this may include infiltration of extra-adrenal adipose tissue and other soft tissues and/or adjacent organs such as the kidneys, pancreas, liver, and spleen.
| Primary tumor (T) |
| ȃ• TX: primary tumor cannot be assessed |
| ȃ• T1: PHEO < 5 cm in greatest dimension, no extra-adrenal invasion |
| ȃ• T2: PHEO ≥ 5 cm OR sympathetic PGL of any size, no extra-adrenal invasion |
| ȃ• T3: Tumor of any size with invasion into surrounding tissuesb |
| Regional lymph nodes (N) |
| ȃ• NX: regional lymph nodes cannot be assessed |
| ȃ• N0: no regional lymph node metastasis |
| ȃ• N1: regional lymph node metastasis |
| Distant metastasis (M) |
| ȃ• M0: no distant metastasis |
| ȃ• M1: distant metastasis |
| ȃȃ• M1a: metastasis to bone only |
| ȃȃ• M1b: metastasis to non-regional lymph node(s), liver, and/or lung; no skeletal metastases |
| ȃȃ• M1c: metastasis to bone and multiple other sites |
| AJCC prognostic stage groups |
| ȃ• Stage I: T1 N0 M0 |
| ȃ• Stage II: T2 N0 M0 |
| ȃ• Stage III: T1-2 N1 M0 or T3 N0-1 M0 |
| ȃ• Stage IV: T1-3 N0-1 M1 |
| Primary tumor (T) |
| ȃ• TX: primary tumor cannot be assessed |
| ȃ• T1: PHEO < 5 cm in greatest dimension, no extra-adrenal invasion |
| ȃ• T2: PHEO ≥ 5 cm OR sympathetic PGL of any size, no extra-adrenal invasion |
| ȃ• T3: Tumor of any size with invasion into surrounding tissuesb |
| Regional lymph nodes (N) |
| ȃ• NX: regional lymph nodes cannot be assessed |
| ȃ• N0: no regional lymph node metastasis |
| ȃ• N1: regional lymph node metastasis |
| Distant metastasis (M) |
| ȃ• M0: no distant metastasis |
| ȃ• M1: distant metastasis |
| ȃȃ• M1a: metastasis to bone only |
| ȃȃ• M1b: metastasis to non-regional lymph node(s), liver, and/or lung; no skeletal metastases |
| ȃȃ• M1c: metastasis to bone and multiple other sites |
| AJCC prognostic stage groups |
| ȃ• Stage I: T1 N0 M0 |
| ȃ• Stage II: T2 N0 M0 |
| ȃ• Stage III: T1-2 N1 M0 or T3 N0-1 M0 |
| ȃ• Stage IV: T1-3 N0-1 M1 |
Abbreviations: PGL, paraganglioma; PHEO, pheochromocytoma; PPGL, pheochromocytoma/paraganglioma.
Jimenez et al (11).
As per AJCC definitions, invasion into surrounding tissues includes any involvement outside the wall/capsule of any organ. For adrenal tumors, this may include infiltration of extra-adrenal adipose tissue and other soft tissues and/or adjacent organs such as the kidneys, pancreas, liver, and spleen.
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