Incidence of subsequent demyelinating diseases of the central nervous system, rather than multiple sclerosis, stratified by severity of septicaemia
| . | N . | Event . | PYs . | Rate . | Crude HR (95% CI) . | Adjusted HR (95% CI) . |
|---|---|---|---|---|---|---|
| All | ||||||
| Comparison group | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Septicaemia | 482 781 | 144 | 2 082 900 | 6.91 | 5.99 (4.73 to 7.58)*** | 4.17 (3.21 to 5.4)*** |
| Length of stay due to septicaemia* | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| 1–5 days | 91 289 | 16 | 523 515 | 3.06 | 2.73 (1.63 to 4.59)*** | 2.17 (1.27 to 3.69)*** |
| >5 days | 391 492 | 128 | 1 559 385 | 8.21 | 7.06 (5.54 to 9.01)*** | 4.73 (3.62 to 6.18)** |
| P for trend | <0.0001 | <0.0001 | ||||
| Severity of septicaemia | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Mild (T1) | 144 548 | 14 | 1 115 282 | 1.26 | 1.12 (0.64 to 1.93) | 0.83 (0.47 to 1.45) |
| Moderate (T2) | 145 160 | 34 | 657 778 | 5.17 | 4.92 (3.36 to 7.19)*** | 3.35 (2.25 to 4.98)*** |
| Severe (T3) | 193 073 | 96 | 309 840 | 31.0 | 28.5 (21.4 to 38.0)*** | 18.7 (13.7 to 25.6)*** |
| P for trend | <0.0001 | <0.0001 |
| . | N . | Event . | PYs . | Rate . | Crude HR (95% CI) . | Adjusted HR (95% CI) . |
|---|---|---|---|---|---|---|
| All | ||||||
| Comparison group | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Septicaemia | 482 781 | 144 | 2 082 900 | 6.91 | 5.99 (4.73 to 7.58)*** | 4.17 (3.21 to 5.4)*** |
| Length of stay due to septicaemia* | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| 1–5 days | 91 289 | 16 | 523 515 | 3.06 | 2.73 (1.63 to 4.59)*** | 2.17 (1.27 to 3.69)*** |
| >5 days | 391 492 | 128 | 1 559 385 | 8.21 | 7.06 (5.54 to 9.01)*** | 4.73 (3.62 to 6.18)** |
| P for trend | <0.0001 | <0.0001 | ||||
| Severity of septicaemia | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Mild (T1) | 144 548 | 14 | 1 115 282 | 1.26 | 1.12 (0.64 to 1.93) | 0.83 (0.47 to 1.45) |
| Moderate (T2) | 145 160 | 34 | 657 778 | 5.17 | 4.92 (3.36 to 7.19)*** | 3.35 (2.25 to 4.98)*** |
| Severe (T3) | 193 073 | 96 | 309 840 | 31.0 | 28.5 (21.4 to 38.0)*** | 18.7 (13.7 to 25.6)*** |
| P for trend | <0.0001 | <0.0001 |
Models adjusted for age, sex and comorbidities listed in table 1. Severity = (total length of hospital stay due to septicaemia during the follow-up duration) ÷ (length of follow-up duration). T1, the first tertile:<0.44%; T2, the second tertile: 0.44%–1.58%; T3 the third tertile:>1.58%.
**p<0.01; ***p<0.001.
*The first time hospitalisation due to septicaemia.
PYs, person-years;Rate, incidence rate, per 100 000 person-years.
Incidence of subsequent demyelinating diseases of the central nervous system, rather than multiple sclerosis, stratified by severity of septicaemia
| . | N . | Event . | PYs . | Rate . | Crude HR (95% CI) . | Adjusted HR (95% CI) . |
|---|---|---|---|---|---|---|
| All | ||||||
| Comparison group | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Septicaemia | 482 781 | 144 | 2 082 900 | 6.91 | 5.99 (4.73 to 7.58)*** | 4.17 (3.21 to 5.4)*** |
| Length of stay due to septicaemia* | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| 1–5 days | 91 289 | 16 | 523 515 | 3.06 | 2.73 (1.63 to 4.59)*** | 2.17 (1.27 to 3.69)*** |
| >5 days | 391 492 | 128 | 1 559 385 | 8.21 | 7.06 (5.54 to 9.01)*** | 4.73 (3.62 to 6.18)** |
| P for trend | <0.0001 | <0.0001 | ||||
| Severity of septicaemia | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Mild (T1) | 144 548 | 14 | 1 115 282 | 1.26 | 1.12 (0.64 to 1.93) | 0.83 (0.47 to 1.45) |
| Moderate (T2) | 145 160 | 34 | 657 778 | 5.17 | 4.92 (3.36 to 7.19)*** | 3.35 (2.25 to 4.98)*** |
| Severe (T3) | 193 073 | 96 | 309 840 | 31.0 | 28.5 (21.4 to 38.0)*** | 18.7 (13.7 to 25.6)*** |
| P for trend | <0.0001 | <0.0001 |
| . | N . | Event . | PYs . | Rate . | Crude HR (95% CI) . | Adjusted HR (95% CI) . |
|---|---|---|---|---|---|---|
| All | ||||||
| Comparison group | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Septicaemia | 482 781 | 144 | 2 082 900 | 6.91 | 5.99 (4.73 to 7.58)*** | 4.17 (3.21 to 5.4)*** |
| Length of stay due to septicaemia* | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| 1–5 days | 91 289 | 16 | 523 515 | 3.06 | 2.73 (1.63 to 4.59)*** | 2.17 (1.27 to 3.69)*** |
| >5 days | 391 492 | 128 | 1 559 385 | 8.21 | 7.06 (5.54 to 9.01)*** | 4.73 (3.62 to 6.18)** |
| P for trend | <0.0001 | <0.0001 | ||||
| Severity of septicaemia | ||||||
| Comparisons | 1 892 825 | 136 | 12 352 780 | 1.10 | Reference group | Reference group |
| Mild (T1) | 144 548 | 14 | 1 115 282 | 1.26 | 1.12 (0.64 to 1.93) | 0.83 (0.47 to 1.45) |
| Moderate (T2) | 145 160 | 34 | 657 778 | 5.17 | 4.92 (3.36 to 7.19)*** | 3.35 (2.25 to 4.98)*** |
| Severe (T3) | 193 073 | 96 | 309 840 | 31.0 | 28.5 (21.4 to 38.0)*** | 18.7 (13.7 to 25.6)*** |
| P for trend | <0.0001 | <0.0001 |
Models adjusted for age, sex and comorbidities listed in table 1. Severity = (total length of hospital stay due to septicaemia during the follow-up duration) ÷ (length of follow-up duration). T1, the first tertile:<0.44%; T2, the second tertile: 0.44%–1.58%; T3 the third tertile:>1.58%.
**p<0.01; ***p<0.001.
*The first time hospitalisation due to septicaemia.
PYs, person-years;Rate, incidence rate, per 100 000 person-years.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
