Table 1.
Open in new tab

Association between clinical characteristics of patients in the derivation cohort and infection with IM.

IM (N, %)Not IM (N, %)P
Total patients2261,115
Patient reported symptoms (N, %)
 Diarrhoea5 (2.2)44 (4.0)0.205
 Nausea25 (11.1)142 (12.7)0.487
 Vomiting11 (4.9)42 (3.8)0.439
 Fatigue105 (46.5)454 (40.7)0.110
 Fever (subjective)98 (43.4)393 (35.3)0.021
 Chills86 (38.0)382 (34.3)0.275
 Headache76 (33.6)437 (39.2)0.117
 Joint pain1 (0.44)37 (3.3)0.018
 No myalgias192 (85.0)814 (73.0)<0.001
 Nasal discharge57 (25.2)421 (37.8)<0.001
 Nasal congestion85 (37.6)491 (44.0)0.075
 No nasal discharge or congestion137 (60.6)592 (53.1)0.038
 Postnasal drip sensation69 (30.5)359 (32.2)0.624
 Rash7 (3.1)13 (1.2)0.029
 Sneezing7 (3.1)51 (4.6)0.320
 Sore throat150 (66.4)705 (63.2)0.370
 Swollen glands136 (60.2)411 (36.9)<0.001
 Hoarseness12 (5.3)67 (6.0)0.684
 Wheezing4 (1.8)27 (2.4)0.552
 No cough159 (70.4)654 (58.7)0.001
 Sinus pressure36 (15.9)258 (23.1)0.017
Clinician documented signs (N, %)
 Lymphadenopathy
  Anterior cervical183 (81.0)850 (76.2)0.122
  Posterior cervical113 (50.0)179 (16.1)<0.001
  Occipital7 (3.1)3 (0.27)<0.001
  Posterior auricular5 (2.2)5 (0.45)0.005
  Preauricular9 (4.0)13 (1.2)0.002
  Supraclavicular2 (0.89)1 (0.09)0.021
  Sublingual5 (2.2)6 (0.54)0.011
  Submental5 (2.2)9 (0.81)0.058
  Any lymphadenopathy other than anterior cervical123 (54.4)201 (18.0)<0.001
 Pharyngeal erythema7 (3.1)46 (4.1)0.469
 Tonsillar erythema86 (38.1)374 (33.5)0.193
 Tonsillar enlargement123 (54.4)597 (53.5)0.808
 Tonsillar exudate82 (36.3)159 (14.3)<0.001
 Fever (temperature ≥100.04°F)5 (2.2)58 (5.2)0.053
Haematologic parameters: n/total (%)
 Lymphocyte count
  ≥3.0 × 10⁹/L173/216 (80.1)69/1,075 (6.4)<0.001
  ≥4.0 × 10⁹/L148/216 (68.5)13/1,075 (1.2)<0.001
 Lymphocyte percent
  >20%189/217 (87.1)524/1,076 (48.7)<0.001
  >30%136/217 (62.7)203/1,076 (18.9)<0.001
  >40%72/217 (33.2)41/1,076 (3.8)<0.001
 Atypical lymphocyte percent
  ≥5%196/217 (90.3)107/1,077 (9.9)<0.001
  ≥10%174/217 (80.2)33/1,077 (3.1)<0.001
  ≥20%107/217 (49.3)4/1,077 (0.37)<0.001
 Neutrophils count <8.0 × 10⁹/L209/216 (96.8)744/1,075 (69.2)<0.001
 Neutrophils <60%196/216 (90.7)247/1,075 (23.0)<0.001
IM (N, %)Not IM (N, %)P
Total patients2261,115
Patient reported symptoms (N, %)
 Diarrhoea5 (2.2)44 (4.0)0.205
 Nausea25 (11.1)142 (12.7)0.487
 Vomiting11 (4.9)42 (3.8)0.439
 Fatigue105 (46.5)454 (40.7)0.110
 Fever (subjective)98 (43.4)393 (35.3)0.021
 Chills86 (38.0)382 (34.3)0.275
 Headache76 (33.6)437 (39.2)0.117
 Joint pain1 (0.44)37 (3.3)0.018
 No myalgias192 (85.0)814 (73.0)<0.001
 Nasal discharge57 (25.2)421 (37.8)<0.001
 Nasal congestion85 (37.6)491 (44.0)0.075
 No nasal discharge or congestion137 (60.6)592 (53.1)0.038
 Postnasal drip sensation69 (30.5)359 (32.2)0.624
 Rash7 (3.1)13 (1.2)0.029
 Sneezing7 (3.1)51 (4.6)0.320
 Sore throat150 (66.4)705 (63.2)0.370
 Swollen glands136 (60.2)411 (36.9)<0.001
 Hoarseness12 (5.3)67 (6.0)0.684
 Wheezing4 (1.8)27 (2.4)0.552
 No cough159 (70.4)654 (58.7)0.001
 Sinus pressure36 (15.9)258 (23.1)0.017
Clinician documented signs (N, %)
 Lymphadenopathy
  Anterior cervical183 (81.0)850 (76.2)0.122
  Posterior cervical113 (50.0)179 (16.1)<0.001
  Occipital7 (3.1)3 (0.27)<0.001
  Posterior auricular5 (2.2)5 (0.45)0.005
  Preauricular9 (4.0)13 (1.2)0.002
  Supraclavicular2 (0.89)1 (0.09)0.021
  Sublingual5 (2.2)6 (0.54)0.011
  Submental5 (2.2)9 (0.81)0.058
  Any lymphadenopathy other than anterior cervical123 (54.4)201 (18.0)<0.001
 Pharyngeal erythema7 (3.1)46 (4.1)0.469
 Tonsillar erythema86 (38.1)374 (33.5)0.193
 Tonsillar enlargement123 (54.4)597 (53.5)0.808
 Tonsillar exudate82 (36.3)159 (14.3)<0.001
 Fever (temperature ≥100.04°F)5 (2.2)58 (5.2)0.053
Haematologic parameters: n/total (%)
 Lymphocyte count
  ≥3.0 × 10⁹/L173/216 (80.1)69/1,075 (6.4)<0.001
  ≥4.0 × 10⁹/L148/216 (68.5)13/1,075 (1.2)<0.001
 Lymphocyte percent
  >20%189/217 (87.1)524/1,076 (48.7)<0.001
  >30%136/217 (62.7)203/1,076 (18.9)<0.001
  >40%72/217 (33.2)41/1,076 (3.8)<0.001
 Atypical lymphocyte percent
  ≥5%196/217 (90.3)107/1,077 (9.9)<0.001
  ≥10%174/217 (80.2)33/1,077 (3.1)<0.001
  ≥20%107/217 (49.3)4/1,077 (0.37)<0.001
 Neutrophils count <8.0 × 10⁹/L209/216 (96.8)744/1,075 (69.2)<0.001
 Neutrophils <60%196/216 (90.7)247/1,075 (23.0)<0.001
Table 1.
Open in new tab

Association between clinical characteristics of patients in the derivation cohort and infection with IM.

IM (N, %)Not IM (N, %)P
Total patients2261,115
Patient reported symptoms (N, %)
 Diarrhoea5 (2.2)44 (4.0)0.205
 Nausea25 (11.1)142 (12.7)0.487
 Vomiting11 (4.9)42 (3.8)0.439
 Fatigue105 (46.5)454 (40.7)0.110
 Fever (subjective)98 (43.4)393 (35.3)0.021
 Chills86 (38.0)382 (34.3)0.275
 Headache76 (33.6)437 (39.2)0.117
 Joint pain1 (0.44)37 (3.3)0.018
 No myalgias192 (85.0)814 (73.0)<0.001
 Nasal discharge57 (25.2)421 (37.8)<0.001
 Nasal congestion85 (37.6)491 (44.0)0.075
 No nasal discharge or congestion137 (60.6)592 (53.1)0.038
 Postnasal drip sensation69 (30.5)359 (32.2)0.624
 Rash7 (3.1)13 (1.2)0.029
 Sneezing7 (3.1)51 (4.6)0.320
 Sore throat150 (66.4)705 (63.2)0.370
 Swollen glands136 (60.2)411 (36.9)<0.001
 Hoarseness12 (5.3)67 (6.0)0.684
 Wheezing4 (1.8)27 (2.4)0.552
 No cough159 (70.4)654 (58.7)0.001
 Sinus pressure36 (15.9)258 (23.1)0.017
Clinician documented signs (N, %)
 Lymphadenopathy
  Anterior cervical183 (81.0)850 (76.2)0.122
  Posterior cervical113 (50.0)179 (16.1)<0.001
  Occipital7 (3.1)3 (0.27)<0.001
  Posterior auricular5 (2.2)5 (0.45)0.005
  Preauricular9 (4.0)13 (1.2)0.002
  Supraclavicular2 (0.89)1 (0.09)0.021
  Sublingual5 (2.2)6 (0.54)0.011
  Submental5 (2.2)9 (0.81)0.058
  Any lymphadenopathy other than anterior cervical123 (54.4)201 (18.0)<0.001
 Pharyngeal erythema7 (3.1)46 (4.1)0.469
 Tonsillar erythema86 (38.1)374 (33.5)0.193
 Tonsillar enlargement123 (54.4)597 (53.5)0.808
 Tonsillar exudate82 (36.3)159 (14.3)<0.001
 Fever (temperature ≥100.04°F)5 (2.2)58 (5.2)0.053
Haematologic parameters: n/total (%)
 Lymphocyte count
  ≥3.0 × 10⁹/L173/216 (80.1)69/1,075 (6.4)<0.001
  ≥4.0 × 10⁹/L148/216 (68.5)13/1,075 (1.2)<0.001
 Lymphocyte percent
  >20%189/217 (87.1)524/1,076 (48.7)<0.001
  >30%136/217 (62.7)203/1,076 (18.9)<0.001
  >40%72/217 (33.2)41/1,076 (3.8)<0.001
 Atypical lymphocyte percent
  ≥5%196/217 (90.3)107/1,077 (9.9)<0.001
  ≥10%174/217 (80.2)33/1,077 (3.1)<0.001
  ≥20%107/217 (49.3)4/1,077 (0.37)<0.001
 Neutrophils count <8.0 × 10⁹/L209/216 (96.8)744/1,075 (69.2)<0.001
 Neutrophils <60%196/216 (90.7)247/1,075 (23.0)<0.001
IM (N, %)Not IM (N, %)P
Total patients2261,115
Patient reported symptoms (N, %)
 Diarrhoea5 (2.2)44 (4.0)0.205
 Nausea25 (11.1)142 (12.7)0.487
 Vomiting11 (4.9)42 (3.8)0.439
 Fatigue105 (46.5)454 (40.7)0.110
 Fever (subjective)98 (43.4)393 (35.3)0.021
 Chills86 (38.0)382 (34.3)0.275
 Headache76 (33.6)437 (39.2)0.117
 Joint pain1 (0.44)37 (3.3)0.018
 No myalgias192 (85.0)814 (73.0)<0.001
 Nasal discharge57 (25.2)421 (37.8)<0.001
 Nasal congestion85 (37.6)491 (44.0)0.075
 No nasal discharge or congestion137 (60.6)592 (53.1)0.038
 Postnasal drip sensation69 (30.5)359 (32.2)0.624
 Rash7 (3.1)13 (1.2)0.029
 Sneezing7 (3.1)51 (4.6)0.320
 Sore throat150 (66.4)705 (63.2)0.370
 Swollen glands136 (60.2)411 (36.9)<0.001
 Hoarseness12 (5.3)67 (6.0)0.684
 Wheezing4 (1.8)27 (2.4)0.552
 No cough159 (70.4)654 (58.7)0.001
 Sinus pressure36 (15.9)258 (23.1)0.017
Clinician documented signs (N, %)
 Lymphadenopathy
  Anterior cervical183 (81.0)850 (76.2)0.122
  Posterior cervical113 (50.0)179 (16.1)<0.001
  Occipital7 (3.1)3 (0.27)<0.001
  Posterior auricular5 (2.2)5 (0.45)0.005
  Preauricular9 (4.0)13 (1.2)0.002
  Supraclavicular2 (0.89)1 (0.09)0.021
  Sublingual5 (2.2)6 (0.54)0.011
  Submental5 (2.2)9 (0.81)0.058
  Any lymphadenopathy other than anterior cervical123 (54.4)201 (18.0)<0.001
 Pharyngeal erythema7 (3.1)46 (4.1)0.469
 Tonsillar erythema86 (38.1)374 (33.5)0.193
 Tonsillar enlargement123 (54.4)597 (53.5)0.808
 Tonsillar exudate82 (36.3)159 (14.3)<0.001
 Fever (temperature ≥100.04°F)5 (2.2)58 (5.2)0.053
Haematologic parameters: n/total (%)
 Lymphocyte count
  ≥3.0 × 10⁹/L173/216 (80.1)69/1,075 (6.4)<0.001
  ≥4.0 × 10⁹/L148/216 (68.5)13/1,075 (1.2)<0.001
 Lymphocyte percent
  >20%189/217 (87.1)524/1,076 (48.7)<0.001
  >30%136/217 (62.7)203/1,076 (18.9)<0.001
  >40%72/217 (33.2)41/1,076 (3.8)<0.001
 Atypical lymphocyte percent
  ≥5%196/217 (90.3)107/1,077 (9.9)<0.001
  ≥10%174/217 (80.2)33/1,077 (3.1)<0.001
  ≥20%107/217 (49.3)4/1,077 (0.37)<0.001
 Neutrophils count <8.0 × 10⁹/L209/216 (96.8)744/1,075 (69.2)<0.001
 Neutrophils <60%196/216 (90.7)247/1,075 (23.0)<0.001
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