Cox regression analysis of the progression from 1 to ≥2 autoAb including all interaction effects identified so far between non-HLA SNPs and main predictive variables in the FDRs cohort: ERBB3 GG × female sex (10), CLEC16A AA × IAA, CTLA4 GA × HLA-DQ2/DQ8, SH2B3 TT × HLA-DQ8, SH2B3 TT × IAA
| Variable . | P . | HR (95% CI) . | Step . | AIC . |
|---|---|---|---|---|
| Age first autoAb+ | <0.001 | 0.910 [0.878−0.944] | 1 | 692.8 |
| Non-(HLA-A*24) (0/1a) | 0.031 | 2.275 [1.080−4.792] | 1 | 692.8 |
| HLA-DQ2/DQ8 (0/1a) | 0.473 | 1 | 692.8 | |
| HLA-DQ8 (0/1a) | NM | |||
| CTLA4 GA × HLA-DQ2/DQ8 | 0.006 | 4.226 [1.526−11.706] | 2 | 660.0 |
| CLEC16A AA × IAA | 0.030 | 1.904 [1.064−3.410] | 3 | 657.0 |
| ERBB3 GG × sex (0/1b) | 0.021 | 0.334 [0.132−0.848] | 4 | 652.9 |
| SH2B3 TT × HLA-DQ8 | 0.045 | 0.275 [0.085−0.889] | 5 | 648.1 |
| SH2B3 TT × IAA | NM |
| Variable . | P . | HR (95% CI) . | Step . | AIC . |
|---|---|---|---|---|
| Age first autoAb+ | <0.001 | 0.910 [0.878−0.944] | 1 | 692.8 |
| Non-(HLA-A*24) (0/1a) | 0.031 | 2.275 [1.080−4.792] | 1 | 692.8 |
| HLA-DQ2/DQ8 (0/1a) | 0.473 | 1 | 692.8 | |
| HLA-DQ8 (0/1a) | NM | |||
| CTLA4 GA × HLA-DQ2/DQ8 | 0.006 | 4.226 [1.526−11.706] | 2 | 660.0 |
| CLEC16A AA × IAA | 0.030 | 1.904 [1.064−3.410] | 3 | 657.0 |
| ERBB3 GG × sex (0/1b) | 0.021 | 0.334 [0.132−0.848] | 4 | 652.9 |
| SH2B3 TT × HLA-DQ8 | 0.045 | 0.275 [0.085−0.889] | 5 | 648.1 |
| SH2B3 TT × IAA | NM |
a0/1: no/yes.
b0/1: male/female.
NM, not retained in model. P values, hazard ratio’s (HR) and 95% confidence intervals are presented for each variable and interaction effect, as well as model AIC values at the indicated step in the model construction by conditional forward approach.
Cox regression analysis of the progression from 1 to ≥2 autoAb including all interaction effects identified so far between non-HLA SNPs and main predictive variables in the FDRs cohort: ERBB3 GG × female sex (10), CLEC16A AA × IAA, CTLA4 GA × HLA-DQ2/DQ8, SH2B3 TT × HLA-DQ8, SH2B3 TT × IAA
| Variable . | P . | HR (95% CI) . | Step . | AIC . |
|---|---|---|---|---|
| Age first autoAb+ | <0.001 | 0.910 [0.878−0.944] | 1 | 692.8 |
| Non-(HLA-A*24) (0/1a) | 0.031 | 2.275 [1.080−4.792] | 1 | 692.8 |
| HLA-DQ2/DQ8 (0/1a) | 0.473 | 1 | 692.8 | |
| HLA-DQ8 (0/1a) | NM | |||
| CTLA4 GA × HLA-DQ2/DQ8 | 0.006 | 4.226 [1.526−11.706] | 2 | 660.0 |
| CLEC16A AA × IAA | 0.030 | 1.904 [1.064−3.410] | 3 | 657.0 |
| ERBB3 GG × sex (0/1b) | 0.021 | 0.334 [0.132−0.848] | 4 | 652.9 |
| SH2B3 TT × HLA-DQ8 | 0.045 | 0.275 [0.085−0.889] | 5 | 648.1 |
| SH2B3 TT × IAA | NM |
| Variable . | P . | HR (95% CI) . | Step . | AIC . |
|---|---|---|---|---|
| Age first autoAb+ | <0.001 | 0.910 [0.878−0.944] | 1 | 692.8 |
| Non-(HLA-A*24) (0/1a) | 0.031 | 2.275 [1.080−4.792] | 1 | 692.8 |
| HLA-DQ2/DQ8 (0/1a) | 0.473 | 1 | 692.8 | |
| HLA-DQ8 (0/1a) | NM | |||
| CTLA4 GA × HLA-DQ2/DQ8 | 0.006 | 4.226 [1.526−11.706] | 2 | 660.0 |
| CLEC16A AA × IAA | 0.030 | 1.904 [1.064−3.410] | 3 | 657.0 |
| ERBB3 GG × sex (0/1b) | 0.021 | 0.334 [0.132−0.848] | 4 | 652.9 |
| SH2B3 TT × HLA-DQ8 | 0.045 | 0.275 [0.085−0.889] | 5 | 648.1 |
| SH2B3 TT × IAA | NM |
a0/1: no/yes.
b0/1: male/female.
NM, not retained in model. P values, hazard ratio’s (HR) and 95% confidence intervals are presented for each variable and interaction effect, as well as model AIC values at the indicated step in the model construction by conditional forward approach.
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