| . | Moderate (n = 10) . | Severe (n = 16) . | Critical (n = 77) . | P value* . |
|---|---|---|---|---|
| Female | 5 (56%) | 8 (53%) | 31 (42%) | 0.64 |
| Age | 58.5 (53.0, 70.2) | 57.0 (52.7, 71.9) | 69.4 (59.1, 76.7) | 0.095 |
| BMI | 26.6 (25.2, 29.2) | 25.8 (25.2, 31.2) | 28.6 (24.8, 31.9) | 0.45 |
| Days since disease onset | 4.5 (1.0, 6.5) | 7.0 (6.0, 13.0) | 7.0 (4.0, 10.0) | 0.13 |
| Clinical parameters at presentation | ||||
| FiO2 (%) | 21 (21, 21) | 21 (21, 22) | 36 (28, 44) | <0.001 |
| Oxygen required | 2 (20%) | 4 (25%) | 61 (79%) | <0.001 |
| sNose mask | 2 | 4 | 41 | |
| Venturi mask 40%/60% | 0 | 0 | 6 | |
| Nonrebreathing mask | 0 | 0 | 14 | |
| Respiratory rate (/min) | 17 (16, 18) | 22 (17, 24) | 24 (20, 30) | 0.002 |
| SBP (mmHg) | 137 (125, 170) | 134 (123, 152) | 134 (119, 149) | 0.69 |
| DBP (mmHg) | 78 (63, 87) | 80 (62, 86) | 79 (69, 85) | 0.93 |
| HR (bpm) | 89 (76, 101) | 80 (70, 94) | 89 (79, 105) | 0.075 |
| Temperature (°C) | 37.5 (37.2, 38.6) | 38.1 (37.0, 38.6) | 38.0 (37.2, 38.4) | 0.94 |
| CRP (g/L) | 13.5 (5.5, 39.0) | 54.0 (42.0, 63.0) | 95.0 (34.5, 152.5) | 0.003 |
| Total leukocyte count (×109/L) | 5.7 (4.4, 6.4) | 6.0 (4.5, 7.0) | 6.8 (5.1, 10.3) | 0.087 |
| Arterial saturation | 0.97 (0.97, 0.98) | 0.96 (0.95, 0.98) | 0.94 (0.92, 0.96) | 0.061 |
| Clinical admission | ||||
| Length of hospital stay (days) | 5.0 (3.0, 7.5) | 13.0 (6.0, 20.0) | <0.001 | |
| ICU admission | 0 (0%) | 22 (36%) | 0.006 | |
| Mortality | 1 (6%) | 21 (27%) | 0.072 | |
| Samples | ||||
| Samples | 10 (100%) | 10 (63%) | 60 (78%) |
| . | Moderate (n = 10) . | Severe (n = 16) . | Critical (n = 77) . | P value* . |
|---|---|---|---|---|
| Female | 5 (56%) | 8 (53%) | 31 (42%) | 0.64 |
| Age | 58.5 (53.0, 70.2) | 57.0 (52.7, 71.9) | 69.4 (59.1, 76.7) | 0.095 |
| BMI | 26.6 (25.2, 29.2) | 25.8 (25.2, 31.2) | 28.6 (24.8, 31.9) | 0.45 |
| Days since disease onset | 4.5 (1.0, 6.5) | 7.0 (6.0, 13.0) | 7.0 (4.0, 10.0) | 0.13 |
| Clinical parameters at presentation | ||||
| FiO2 (%) | 21 (21, 21) | 21 (21, 22) | 36 (28, 44) | <0.001 |
| Oxygen required | 2 (20%) | 4 (25%) | 61 (79%) | <0.001 |
| sNose mask | 2 | 4 | 41 | |
| Venturi mask 40%/60% | 0 | 0 | 6 | |
| Nonrebreathing mask | 0 | 0 | 14 | |
| Respiratory rate (/min) | 17 (16, 18) | 22 (17, 24) | 24 (20, 30) | 0.002 |
| SBP (mmHg) | 137 (125, 170) | 134 (123, 152) | 134 (119, 149) | 0.69 |
| DBP (mmHg) | 78 (63, 87) | 80 (62, 86) | 79 (69, 85) | 0.93 |
| HR (bpm) | 89 (76, 101) | 80 (70, 94) | 89 (79, 105) | 0.075 |
| Temperature (°C) | 37.5 (37.2, 38.6) | 38.1 (37.0, 38.6) | 38.0 (37.2, 38.4) | 0.94 |
| CRP (g/L) | 13.5 (5.5, 39.0) | 54.0 (42.0, 63.0) | 95.0 (34.5, 152.5) | 0.003 |
| Total leukocyte count (×109/L) | 5.7 (4.4, 6.4) | 6.0 (4.5, 7.0) | 6.8 (5.1, 10.3) | 0.087 |
| Arterial saturation | 0.97 (0.97, 0.98) | 0.96 (0.95, 0.98) | 0.94 (0.92, 0.96) | 0.061 |
| Clinical admission | ||||
| Length of hospital stay (days) | 5.0 (3.0, 7.5) | 13.0 (6.0, 20.0) | <0.001 | |
| ICU admission | 0 (0%) | 22 (36%) | 0.006 | |
| Mortality | 1 (6%) | 21 (27%) | 0.072 | |
| Samples | ||||
| Samples | 10 (100%) | 10 (63%) | 60 (78%) |
P value using χ2, Kruskal-Wallis, or Mann-Whitney U-test where appropriate.
Categorical values are described as N (%) and continuous values are described as median with interquartile range.
Abbreviations: BMI—body mass index; SBP—systolic blood pressure; DBP—diastolic blood pressure; CRP—C-reactive protein; and ICU—intensive care unit.
Number of missing values: BMI—12%; onset of symptoms—12%; respiratory rate—16%; systolic blood pressure—4%; diastolic blood pressure 5%; pulse rate—8%; temperature—11%; CRP—18%; total leukocyte count—17%; arterial saturation—43%; absolute cell counts—2%; and all others: no missing values.
| . | Moderate (n = 10) . | Severe (n = 16) . | Critical (n = 77) . | P value* . |
|---|---|---|---|---|
| Female | 5 (56%) | 8 (53%) | 31 (42%) | 0.64 |
| Age | 58.5 (53.0, 70.2) | 57.0 (52.7, 71.9) | 69.4 (59.1, 76.7) | 0.095 |
| BMI | 26.6 (25.2, 29.2) | 25.8 (25.2, 31.2) | 28.6 (24.8, 31.9) | 0.45 |
| Days since disease onset | 4.5 (1.0, 6.5) | 7.0 (6.0, 13.0) | 7.0 (4.0, 10.0) | 0.13 |
| Clinical parameters at presentation | ||||
| FiO2 (%) | 21 (21, 21) | 21 (21, 22) | 36 (28, 44) | <0.001 |
| Oxygen required | 2 (20%) | 4 (25%) | 61 (79%) | <0.001 |
| sNose mask | 2 | 4 | 41 | |
| Venturi mask 40%/60% | 0 | 0 | 6 | |
| Nonrebreathing mask | 0 | 0 | 14 | |
| Respiratory rate (/min) | 17 (16, 18) | 22 (17, 24) | 24 (20, 30) | 0.002 |
| SBP (mmHg) | 137 (125, 170) | 134 (123, 152) | 134 (119, 149) | 0.69 |
| DBP (mmHg) | 78 (63, 87) | 80 (62, 86) | 79 (69, 85) | 0.93 |
| HR (bpm) | 89 (76, 101) | 80 (70, 94) | 89 (79, 105) | 0.075 |
| Temperature (°C) | 37.5 (37.2, 38.6) | 38.1 (37.0, 38.6) | 38.0 (37.2, 38.4) | 0.94 |
| CRP (g/L) | 13.5 (5.5, 39.0) | 54.0 (42.0, 63.0) | 95.0 (34.5, 152.5) | 0.003 |
| Total leukocyte count (×109/L) | 5.7 (4.4, 6.4) | 6.0 (4.5, 7.0) | 6.8 (5.1, 10.3) | 0.087 |
| Arterial saturation | 0.97 (0.97, 0.98) | 0.96 (0.95, 0.98) | 0.94 (0.92, 0.96) | 0.061 |
| Clinical admission | ||||
| Length of hospital stay (days) | 5.0 (3.0, 7.5) | 13.0 (6.0, 20.0) | <0.001 | |
| ICU admission | 0 (0%) | 22 (36%) | 0.006 | |
| Mortality | 1 (6%) | 21 (27%) | 0.072 | |
| Samples | ||||
| Samples | 10 (100%) | 10 (63%) | 60 (78%) |
| . | Moderate (n = 10) . | Severe (n = 16) . | Critical (n = 77) . | P value* . |
|---|---|---|---|---|
| Female | 5 (56%) | 8 (53%) | 31 (42%) | 0.64 |
| Age | 58.5 (53.0, 70.2) | 57.0 (52.7, 71.9) | 69.4 (59.1, 76.7) | 0.095 |
| BMI | 26.6 (25.2, 29.2) | 25.8 (25.2, 31.2) | 28.6 (24.8, 31.9) | 0.45 |
| Days since disease onset | 4.5 (1.0, 6.5) | 7.0 (6.0, 13.0) | 7.0 (4.0, 10.0) | 0.13 |
| Clinical parameters at presentation | ||||
| FiO2 (%) | 21 (21, 21) | 21 (21, 22) | 36 (28, 44) | <0.001 |
| Oxygen required | 2 (20%) | 4 (25%) | 61 (79%) | <0.001 |
| sNose mask | 2 | 4 | 41 | |
| Venturi mask 40%/60% | 0 | 0 | 6 | |
| Nonrebreathing mask | 0 | 0 | 14 | |
| Respiratory rate (/min) | 17 (16, 18) | 22 (17, 24) | 24 (20, 30) | 0.002 |
| SBP (mmHg) | 137 (125, 170) | 134 (123, 152) | 134 (119, 149) | 0.69 |
| DBP (mmHg) | 78 (63, 87) | 80 (62, 86) | 79 (69, 85) | 0.93 |
| HR (bpm) | 89 (76, 101) | 80 (70, 94) | 89 (79, 105) | 0.075 |
| Temperature (°C) | 37.5 (37.2, 38.6) | 38.1 (37.0, 38.6) | 38.0 (37.2, 38.4) | 0.94 |
| CRP (g/L) | 13.5 (5.5, 39.0) | 54.0 (42.0, 63.0) | 95.0 (34.5, 152.5) | 0.003 |
| Total leukocyte count (×109/L) | 5.7 (4.4, 6.4) | 6.0 (4.5, 7.0) | 6.8 (5.1, 10.3) | 0.087 |
| Arterial saturation | 0.97 (0.97, 0.98) | 0.96 (0.95, 0.98) | 0.94 (0.92, 0.96) | 0.061 |
| Clinical admission | ||||
| Length of hospital stay (days) | 5.0 (3.0, 7.5) | 13.0 (6.0, 20.0) | <0.001 | |
| ICU admission | 0 (0%) | 22 (36%) | 0.006 | |
| Mortality | 1 (6%) | 21 (27%) | 0.072 | |
| Samples | ||||
| Samples | 10 (100%) | 10 (63%) | 60 (78%) |
P value using χ2, Kruskal-Wallis, or Mann-Whitney U-test where appropriate.
Categorical values are described as N (%) and continuous values are described as median with interquartile range.
Abbreviations: BMI—body mass index; SBP—systolic blood pressure; DBP—diastolic blood pressure; CRP—C-reactive protein; and ICU—intensive care unit.
Number of missing values: BMI—12%; onset of symptoms—12%; respiratory rate—16%; systolic blood pressure—4%; diastolic blood pressure 5%; pulse rate—8%; temperature—11%; CRP—18%; total leukocyte count—17%; arterial saturation—43%; absolute cell counts—2%; and all others: no missing values.
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