Table 2. Open in new tab Independent...

SNP

CHR

P_23&me

BETA^a

SE^a

P_META

Signal source

rs1537818

39647038

2.76E−05

−0.01755

0.004182

1.31E−09

MTAG

rs633715

177852580

4.60E−07

−0.02466

0.004898

3.49E−08

MTAG_BMIadj

rs72902175

157013035

9.30E−10

0.035999

0.005866

3.67E−14

MTAG

rs1403848

77609655

7.51E−05

−0.01569

0.003962

9.30E−09

MTAG

rs4076077

170863509

3.70E−06

−0.01797

0.003882

4.26E−09

MTAG

rs1428381

122693901

0.000369

0.015265

0.004283

4.83E−09

MTAG

rs2715039

84094964

4.61E−05

−0.01611

0.003952

2.04E−08

MTAG

rs7005777

78233600

5.18E−05

0.017513

0.00433

1.12E−08

MTAG

rs8176749

136131188

1.47E−05

−0.03212

0.007433

3.78E−09

MTAG

rs10756798

16739763

3.70E−09

−0.02425

0.004115

3.28E−08

MTAG_BMIadj

rs1444789

9064361

2.40E−13

−0.03701

0.005042

1.10E−09

MTAG

rs6265

27679916

1.12E−05

−0.02198

0.00501

1.79E−14

MTAG

rs1815739

66328095

1.19E−06

0.018979

0.003906

2.10E−08

MTAG

rs4923536

28422496

1.52E−10

0.025071

0.003915

7.51E−11

MTAG_BMIadj

rs28758996

121960480

0.00122

−0.01282

0.003963

1.21E−08

META

rs8045335

60607116

1.41E−09

−0.02374

0.003922

1.24E−08

MTAG

rs9933881

1740691

3.68E−07

−0.03664

0.007183

2.54E−08

MTAG

rs12603115

46248994

3.95E−06

−0.01812

0.003926

8.14E−10

MTAG

rs227731

54773238

2.40E−11

−0.02603

0.003896

3.96E−09

MTAG

rs4987719

60960310

1.28E−08

0.061095

0.01068

4.72E−09

MTAG

rs35445111

32172047

2.62E−12

0.04751

0.006817

1.62E−11

MTAG

rs6113592

22229505

6.42E−07

0.019892

0.003998

7.82E−11

MTAG

rs6038517

6458205

0.000217

−0.01703

0.0046

2.19E−08

MTAG

Table 2.

Open in new tab

Independent hits associated with SA and replicated in 23andMe

SNP	CHR	BP	A1	A2	P_23&me	BETA^a	SE^a	P_META	Signal source
rs1537818	1	39647038	G	A	2.76E−05	−0.01755	0.004182	1.31E−09	MTAG
rs633715	1	177852580	T	C	4.60E−07	−0.02466	0.004898	3.49E−08	MTAG_BMIadj
rs72902175	2	157013035	T	C	9.30E−10	0.035999	0.005866	3.67E−14	MTAG
rs1403848	3	77609655	C	A	7.51E−05	−0.01569	0.003962	9.30E−09	MTAG
rs4076077	5	170863509	T	C	3.70E−06	−0.01797	0.003882	4.26E−09	MTAG
rs1428381	5	122693901	G	A	0.000369	0.015265	0.004283	4.83E−09	MTAG
rs2715039	7	84094964	C	A	4.61E−05	−0.01611	0.003952	2.04E−08	MTAG
rs7005777	8	78233600	T	G	5.18E−05	0.017513	0.00433	1.12E−08	MTAG
rs8176749	9	136131188	T	C	1.47E−05	−0.03212	0.007433	3.78E−09	MTAG
rs10756798	9	16739763	T	C	3.70E−09	−0.02425	0.004115	3.28E−08	MTAG_BMIadj
rs1444789	10	9064361	T	C	2.40E−13	−0.03701	0.005042	1.10E−09	MTAG
rs6265	11	27679916	T	C	1.12E−05	−0.02198	0.00501	1.79E−14	MTAG
rs1815739	11	66328095	T	C	1.19E−06	0.018979	0.003906	2.10E−08	MTAG
rs4923536	11	28422496	G	A	1.52E−10	0.025071	0.003915	7.51E−11	MTAG_BMIadj
rs28758996	12	121960480	G	A	0.00122	−0.01282	0.003963	1.21E−08	META
rs1389799	12	65824846	G	A	3.57E−25	0.04184	0.004032	1.38E−18	MTAG_BMIadj
rs4554968	12	4372609	G	A	0.000854	0.013381	0.004011	4.47E−08	MTAG_BMIadj
rs592333	13	51340315	G	A	9.04E−23	−0.03997	0.004068	1.69E−14	MTAG
rs11852496	15	83817559	T	C	3.17E−05	−0.01918	0.004605	1.71E−06	META
rs11634019	15	76634680	T	C	4.44E−10	0.027288	0.00438	1.84E−09	MTAG
rs11075985	16	53805207	C	A	1.13E−05	0.017161	0.003907	5.41E−20	META
rs8045335	16	60607116	G	A	1.41E−09	−0.02374	0.003922	1.24E−08	MTAG
rs9933881	16	1740691	T	C	3.68E−07	−0.03664	0.007183	2.54E−08	MTAG
rs12603115	17	46248994	T	C	3.95E−06	−0.01812	0.003926	8.14E−10	MTAG
rs227731	17	54773238	T	G	2.40E−11	−0.02603	0.003896	3.96E−09	MTAG
rs4987719	18	60960310	T	C	1.28E−08	0.061095	0.01068	4.72E−09	MTAG
rs35445111	19	32172047	G	A	2.62E−12	0.04751	0.006817	1.62E−11	MTAG
rs6113592	20	22229505	G	A	6.42E−07	0.019892	0.003998	7.82E−11	MTAG
rs6038517	20	6458205	G	A	0.000217	−0.01703	0.0046	2.19E−08	MTAG

SNP	CHR	BP	A1	A2	P_23&me	BETA^a	SE^a	P_META	Signal source
rs1537818	1	39647038	G	A	2.76E−05	−0.01755	0.004182	1.31E−09	MTAG
rs633715	1	177852580	T	C	4.60E−07	−0.02466	0.004898	3.49E−08	MTAG_BMIadj
rs72902175	2	157013035	T	C	9.30E−10	0.035999	0.005866	3.67E−14	MTAG
rs1403848	3	77609655	C	A	7.51E−05	−0.01569	0.003962	9.30E−09	MTAG
rs4076077	5	170863509	T	C	3.70E−06	−0.01797	0.003882	4.26E−09	MTAG
rs1428381	5	122693901	G	A	0.000369	0.015265	0.004283	4.83E−09	MTAG
rs2715039	7	84094964	C	A	4.61E−05	−0.01611	0.003952	2.04E−08	MTAG
rs7005777	8	78233600	T	G	5.18E−05	0.017513	0.00433	1.12E−08	MTAG
rs8176749	9	136131188	T	C	1.47E−05	−0.03212	0.007433	3.78E−09	MTAG
rs10756798	9	16739763	T	C	3.70E−09	−0.02425	0.004115	3.28E−08	MTAG_BMIadj
rs1444789	10	9064361	T	C	2.40E−13	−0.03701	0.005042	1.10E−09	MTAG
rs6265	11	27679916	T	C	1.12E−05	−0.02198	0.00501	1.79E−14	MTAG
rs1815739	11	66328095	T	C	1.19E−06	0.018979	0.003906	2.10E−08	MTAG
rs4923536	11	28422496	G	A	1.52E−10	0.025071	0.003915	7.51E−11	MTAG_BMIadj
rs28758996	12	121960480	G	A	0.00122	−0.01282	0.003963	1.21E−08	META
rs1389799	12	65824846	G	A	3.57E−25	0.04184	0.004032	1.38E−18	MTAG_BMIadj
rs4554968	12	4372609	G	A	0.000854	0.013381	0.004011	4.47E−08	MTAG_BMIadj
rs592333	13	51340315	G	A	9.04E−23	−0.03997	0.004068	1.69E−14	MTAG
rs11852496	15	83817559	T	C	3.17E−05	−0.01918	0.004605	1.71E−06	META
rs11634019	15	76634680	T	C	4.44E−10	0.027288	0.00438	1.84E−09	MTAG
rs11075985	16	53805207	C	A	1.13E−05	0.017161	0.003907	5.41E−20	META
rs8045335	16	60607116	G	A	1.41E−09	−0.02374	0.003922	1.24E−08	MTAG
rs9933881	16	1740691	T	C	3.68E−07	−0.03664	0.007183	2.54E−08	MTAG
rs12603115	17	46248994	T	C	3.95E−06	−0.01812	0.003926	8.14E−10	MTAG
rs227731	17	54773238	T	G	2.40E−11	−0.02603	0.003896	3.96E−09	MTAG
rs4987719	18	60960310	T	C	1.28E−08	0.061095	0.01068	4.72E−09	MTAG
rs35445111	19	32172047	G	A	2.62E−12	0.04751	0.006817	1.62E−11	MTAG
rs6113592	20	22229505	G	A	6.42E−07	0.019892	0.003998	7.82E−11	MTAG
rs6038517	20	6458205	G	A	0.000217	−0.01703	0.0046	2.19E−08	MTAG

GWAS and replication significant SNPs. Results are shown for variants with genome-wide evidence of association (p < 5e−8) in at least one of the main analyses, and evidence of replication in 23andMe. Abbreviations: META, sleep apnea meta-analysis; MTAG, sleep apnea plus snoring MTAG. MTAG_BMIadj, sleep apnea plus snoring MTAG adjusting for BMI using mtCOJO.

^aInformation based on the 23andMe GWAS.

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