Table 4. Open in new tab Standardized...

	Episodic memory	Executive function	Language	Visuoconstruction	Processing speed
Indirect via vascular diseases	−0.002	[−0.004, −0.001]	−0.005^*	[−0.009, −0.001]	−0.004^*	[−0.008, −0.001]	−0.006^*	[−0.011, −0.002]	−0.005^*	[−0.009, −0.001]
Indirect via Depressive symptoms	−0.007^*	[−0.011, −0.002]	−0.007^*	[−0.012, −0.003]	−0.008^*	[−0.012, −0.003]	−0.007^*	[−0.011, −0.002]	−0.008^*	[−0.013, −0.004]
Total indirect	−0.008^*	[−0.013, −0.003]	−0.012^*	[−0.018, −0.007]	−0.012^*	[−0.018, −0.006]	−0.013^*	[−0.019, −0.007]	−0.013^*	[−0.019, −0.007]
Direct	−0.049^*	[−0.084, −0.014]	−0.035	[−0.067, −0.002]	−0.051^*	[−0.085, −0.018]	−0.028	[−0.063, 0.007]	−0.028	[−0.060, 0.005]

	Episodic memory	Executive function	Language	Visuoconstruction	Processing speed
Indirect via vascular diseases	−0.002	[−0.004, −0.001]	−0.005^*	[−0.009, −0.001]	−0.004^*	[−0.008, −0.001]	−0.006^*	[−0.011, −0.002]	−0.005^*	[−0.009, −0.001]
Indirect via Depressive symptoms	−0.007^*	[−0.011, −0.002]	−0.007^*	[−0.012, −0.003]	−0.008^*	[−0.012, −0.003]	−0.007^*	[−0.011, −0.002]	−0.008^*	[−0.013, −0.004]
Total indirect	−0.008^*	[−0.013, −0.003]	−0.012^*	[−0.018, −0.007]	−0.012^*	[−0.018, −0.006]	−0.013^*	[−0.019, −0.007]	−0.013^*	[−0.019, −0.007]
Direct	−0.049^*	[−0.084, −0.014]	−0.035	[−0.067, −0.002]	−0.051^*	[−0.085, −0.018]	−0.028	[−0.063, 0.007]	−0.028	[−0.060, 0.005]

Table 4.

Standardized specific indirect, total indirect, and direct path estimates between difficulty initiating sleep in 2002 and cognition in 2016 via the mediators

	Episodic memory		Executive function		Language		Visuoconstruction		Processing speed
Path	β	95% CI	β	95% CI	β	95% CI	β	95% CI	β	95% CI
Indirect via vascular diseases	−0.002	[−0.004, −0.001]	−0.005^*	[−0.009, −0.001]	−0.004^*	[−0.008, −0.001]	−0.006^*	[−0.011, −0.002]	−0.005^*	[−0.009, −0.001]
Indirect via Depressive symptoms	−0.007^*	[−0.011, −0.002]	−0.007^*	[−0.012, −0.003]	−0.008^*	[−0.012, −0.003]	−0.007^*	[−0.011, −0.002]	−0.008^*	[−0.013, −0.004]
Total indirect	−0.008^*	[−0.013, −0.003]	−0.012^*	[−0.018, −0.007]	−0.012^*	[−0.018, −0.006]	−0.013^*	[−0.019, −0.007]	−0.013^*	[−0.019, −0.007]
Direct	−0.049^*	[−0.084, −0.014]	−0.035	[−0.067, −0.002]	−0.051^*	[−0.085, −0.018]	−0.028	[−0.063, 0.007]	−0.028	[−0.060, 0.005]

	Episodic memory		Executive function		Language		Visuoconstruction		Processing speed
Path	β	95% CI	β	95% CI	β	95% CI	β	95% CI	β	95% CI
Indirect via vascular diseases	−0.002	[−0.004, −0.001]	−0.005^*	[−0.009, −0.001]	−0.004^*	[−0.008, −0.001]	−0.006^*	[−0.011, −0.002]	−0.005^*	[−0.009, −0.001]
Indirect via Depressive symptoms	−0.007^*	[−0.011, −0.002]	−0.007^*	[−0.012, −0.003]	−0.008^*	[−0.012, −0.003]	−0.007^*	[−0.011, −0.002]	−0.008^*	[−0.013, −0.004]
Total indirect	−0.008^*	[−0.013, −0.003]	−0.012^*	[−0.018, −0.007]	−0.012^*	[−0.018, −0.006]	−0.013^*	[−0.019, −0.007]	−0.013^*	[−0.019, −0.007]
Direct	−0.049^*	[−0.084, −0.014]	−0.035	[−0.067, −0.002]	−0.051^*	[−0.085, −0.018]	−0.028	[−0.063, 0.007]	−0.028	[−0.060, 0.005]

^*Significant after adjustment for multiple comparisons using the Benjamini–Hochberg method.

CI= confidence interval.

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